Skip to main content
SpringerLink
Log in

Use of a multi-species probiotic

For the prevention of antibiotic associated diarrhea

  • Research
  • Published:
Nutrafoods

Summary

Previous experience in our hospital and in the literature indicate an incidence of diarrhea between 5% and 50% after antibiotic treatment (depending on the antibiotic used).

In the present study, a total of 199 patients receiving antibiotic treatment after surgical intervention received additionally to their antibiotic treatment daily two sachets of the multispecies probiotic MSP. The application of MSP reduced the incidence of diarrhea to 0.5% (1 patient out of the199 probands). The probiotic administration was forgotten in two subjects, both generated AAD (with evidence of Clostridium difficile in one subject). In conclusion, the use of the multispecies probiotic for primary prevention of AAD was found to be successful. Prevention of AAD in this manner promises to result in a reduction of overall costs for health care.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Zoetendal EG, Akkermans AD, De Vos WM (1998) Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria Appl Environ Microbiol 64 3854–3859

    CAS  Google Scholar 

  2. Isolauri E, Salminen S, Ouwehand AC (2004) Probiotics. Best practice & research Clin Gastroenterol 18 299–313

    Google Scholar 

  3. Barza M, Giuliano M, Jacobus NV, Gorbach SL (1987) Effect of broad-spectrum parenteral antibiotics on “colonization resistance” of intestinal microflora of humans Antimicrob Agents Chemother 31 723–727

    CAS  Google Scholar 

  4. Edlund C, Nord CE (2000) Effect on the human normal microflora of oral antibiotics for treatment of urinary tract infections. J Antimicrob Chemother 46 (Suppl 1) 41–48

    CAS  Google Scholar 

  5. Bartlett JG (1992) Antibiotic-associated diarrhea Clin Infect Dis 15 573–581

    CAS  Google Scholar 

  6. McFarland LV (1998) Epidemiology, risk factors and treatments for antibiotic-associated diarrhea Dig Dis 16 292–307

    CAS  Google Scholar 

  7. Jernberg C, Löfmark S, Edlund C, Jansson JK (2007) Long-term ecological impacts of antibiotic administration on the human intestinal microbiota ISME J 1 56–66

    CAS  Google Scholar 

  8. Madden JA, Plummer SF, Tang J, Garaiova et al (2005) Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: a double-blind, placebo-controlled pilot study Int Immunopharmacol 5 1091–1097

    CAS  Google Scholar 

  9. Hammer HF (2003) Schnellrepetitorium: Antibiotic associated diarrhoea (AAD) J Gastroenterol Hepatol Erkr 1 30–33

    Google Scholar 

  10. Hammer HF, Aichbichler B (2003) Probiotika und Präbiotika; Grundlagen, Einsatz und Wirkung beim gesunden und kranken Menschen. J Ernährungsmed 5 1624

    Google Scholar 

  11. Preidis GA, Versalovic J (2009) Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era. Special issue: Intestinal microbes in health and disease Gastroenterol 136 2015–2031

    CAS  Google Scholar 

  12. Högenauer C, Hammer HF, Krejs GJ, Reisinger EC (1998) Mechanisms and management of antibiotic-associated diarrhea Clin Infect Dis 27 702–710

    Google Scholar 

  13. Cremonini F, Di Caro S, Nista EC, Bartolozzi F et al (2002) Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhoea Aliment Pharmacol Ther 16 1461–1467

    CAS  Google Scholar 

  14. D’Souza AL, Rajkumar C, Cooke J, Bulpitt CJ (2002) Probiotics in prevention of antibiotic associated diarrhoea: meta- analysis BMJ 324 1361

    Google Scholar 

  15. Huang JS, Bousvaros A, Lee JW, Diaz A, Davidson EJ (2002) Efficacy of probiotic use in acute diarrhea in children: a meta-analysis. Dig Dis Sci 47 2625–2634

    CAS  Google Scholar 

  16. Van Niel CW, Feudtner C, Garrison MM, Christakis DA (2002) Lactobacillus therapy for acute diarrhea in children: a meta-analysis Pediatrics 109 678–684

    Google Scholar 

  17. Johnston BC, Supina AL, Vohra S (2006) Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebo-controlled trials CMAJ 175 377–383

    Google Scholar 

  18. Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE (2006) Efficacy of probiotics in prevention of acute diarrhoea: a metaanalysis of masked, randomized, placebo-controlled trials Lancet Infect Dis 6 374–382

    Google Scholar 

  19. Szajewska H, Ruszczynski M, Radzikowski A (2006) Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials J Pediatr 149 367–372

    Google Scholar 

  20. McFarland LV (2006) Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease The J Gastroenterol 101 812–822.

    Google Scholar 

  21. Hickson M, D’Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C, Bulpitt CJ (2007) Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial BMJ 335 80

    Google Scholar 

  22. Timmerman HM, Koning CJ, Mulder L, Rombouts FM, Beynen AC (2004) Monostrain, multistrain and multi-species probiotics — a comparison of functionality and efficacy Int J Food Microbiol 96 219–233

    CAS  Google Scholar 

  23. Steyer GE (2009) Multispezies-Probiotika der dritten Generation für zeitgemäße Therapien. 50 Chirurgenkongress In: Universum Innere Medizin 5 117

    Google Scholar 

  24. Mulder L (2008) A multispecies probiotic food supplement (Ecologic® 825) for IBD NUTRAfoods 7 89–91

    Google Scholar 

  25. Koning CJ, Jonkers DM, Stobberingh EE, Mulder L, Rombouts FM, Stockbrügger RW (2008) The effect of a multispecies probiotic on the intestinal microbiota and bowel movements in healthy volunteers taking the antibiotic amoxycillin The Am J Gastroenterol 103 178–189

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery Country clinic, Thermenregion Neunkirchen, Austria Peischinger Street 19, A-2620, Neunkirchen, Austria

    Friedrich C. Lang

Authors
  1. Friedrich C. Lang
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Omni-BIOTIC®10 AAD (Ecologic®AAD) is a multispecies probiotic produced by Winclove, Bio Industries, Amsterdam, The Netherlands

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lang, F.C. Use of a multi-species probiotic. Nutrafoods 9, 27–31 (2010). https://doi.org/10.1007/BF03223333

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03223333

Key words

Search

Navigation