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Surface modification of magnetites using maltotrionic acid and folic acid for molecular imaging

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Abstract

Highly hydrophilic, uniform, superparamagnetic and nontoxic maltotrionic acid (MA)-coated magnetite nano-particles (MAM) were prepared and characterized by TEM, DLS, XRD and VSM. MA was used to improve the biocompatibility, monodispersity and non-specific intracellular uptake of nanoparticles. Folic acid (FA) was subsequently conjugated to the MAM to preferentially target KB cells (cancer cells) that have folate receptors expressed on their surfaces and to facilitate nanoparticles in their transit across the cell membrane. Finally, fluorescence isothiocyanate (FITC) was added to the nanoparticles to visualize the nanoparticle internalization into KB cells. After the cells were cultured in a media containing the MAM and MAM-folate conjugate (FAMAM), the results of fluorescence and confocal microscopy showed that both types of nanoparticles were internalized into the cells. Nevertheless, the amount of FAMAM uptake was higher than that of MAM. This result indicated that nanoparticles modified with MA and FA could be used to facilitate the nanoparticle uptake to specific KB cells (cancer cells) for molecular imaging.

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Authors and Affiliations

  1. Dept. of Polymer Science, Kyungpook National University, 702-701, Daegu, Korea

    K. M. Kamruzzaman Selim, Joo-Hee Lee, Sun-Jung Kim, Zhicai Xing & Inn-Kyu Kang

  2. Dept. of Diagnostic Radiology, Kyungpook National University, 700-422, Daegu, Korea

    Yongmin Chang

  3. College of Chemistry and Molecular Eng., Peking University, 100871, Beijing, China

    Haiqing Guo

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  1. K. M. Kamruzzaman Selim
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  2. Joo-Hee Lee
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  3. Sun-Jung Kim
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  4. Zhicai Xing
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  5. Inn-Kyu Kang
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  6. Yongmin Chang
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  7. Haiqing Guo
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Correspondence to Inn-Kyu Kang.

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Selim, K.M.K., Lee, JH., Kim, SJ. et al. Surface modification of magnetites using maltotrionic acid and folic acid for molecular imaging. Macromol. Res. 14, 646–653 (2006). https://doi.org/10.1007/BF03218738

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  • DOI: https://doi.org/10.1007/BF03218738

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