Conclusions
In this study, we demonstrate that cyclic strain increased the proliferation of HDFs and subsequent expression of ECM proteins. Specifically, HDFs engineered under the cyclic stretching exhibited higher proliferation and up-regulated expression of collagen type IV and fibronectin. These cellular features could allow the engineered HDF tissues to exhibit contractile functions. Future studies will examine dose-dependent responses of various skin cells cultured in nanofibrous scaffold under mechanical loading that vary in strain amplitude, rate, frequency, and duration.
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Jeong, S.I., Lee, Y.M. & Shin, H. Tissue engineering using a cyclic strain bioreactor and gelatin/PLCL scaffolds. Macromol. Res. 16, 567–569 (2008). https://doi.org/10.1007/BF03218561
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DOI: https://doi.org/10.1007/BF03218561