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Preparation and characterization of pH-sensitive poly(ethylene oxide) grafted methacrylic acid and acrylic acid hydrogels by γ-ray irradiation

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Abstract

pH-sensitive hydrogels were studied as a drug carrier for the protection of insulin from the acidic environment of the stomach before releasing it in the small intestine. In this study, hydrogels based on poly(ethylene oxide) (PEO) networks grafted with methacrylic acid (MAA) or acrylic acid (AAc) were prepared via a two-step process. PEO hydrogels were prepared by γ-ray irradiation (radiation dose: 50 kGy, dose rate: 7.66 kGy/h), grafted by either MAA or AAc monomers onto the PEO hydrogels and finally underwent irradiation (radiation dose: 5–20 kGy, dose rate: 2.15 kGy/h). These grafted hydrogels showed a pH-sensitive swelling behavior. The grafted hydrogels were used as a carrier for the drug delivery systems for the controlled release of insulin. Drug-loaded hydrogels were placed in simulated gastric fluid (SGF, pH 1.2) for 2 hr and then in simulated intestinal fluid (SIF, pH 6.8). Thein vitro drug release behaviors of these hydrogels were examined by quantification analysis with a UV-Vis spectrophotometer.

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Authors and Affiliations

  1. School of Chemical Engineering, Collage of Engineering, Hanyang University, 133-791, Seoul, Korea

    Youn Mook Lim & Young Moo Lee

  2. Radiation Application Research Division, Korea Atomic Energy Research Institute, 305-600, Daejeon, Korea

    Young Chang Nho

Authors
  1. Youn Mook Lim
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  2. Young Moo Lee
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  3. Young Chang Nho
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Correspondence to Young Chang Nho.

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Lim, Y.M., Lee, Y.M. & Nho, Y.C. Preparation and characterization of pH-sensitive poly(ethylene oxide) grafted methacrylic acid and acrylic acid hydrogels by γ-ray irradiation. Macromol. Res. 13, 327–333 (2005). https://doi.org/10.1007/BF03218461

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  • DOI: https://doi.org/10.1007/BF03218461

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