Skip to main content
SpringerLink
Log in

The effect of gamma irradiation on PLGA and release behavior of BCNU from PLGA wafer

  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

The objectives of this study were to investigate the influence of gamma irradiation for sterilization on poly(D,L-lactide-co-glycolide) (PLGA) with different molecular weight and the effect of gamma irradiation on the release behavior of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine) from PLGA wafer with various irradiation doses. The effect of gamma irradiation on PLGA was evaluated by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and electron paramagnetic resonance (EPR). The weight average molecular weight (M w) and glass transition temperature (T g) of PLGA decreased after gamma irradiation. The extent ofM w reduction was dependent on irradiation dose and PLGA molecular weight. Using EPR spectroscopy, we successfully detected gamma irradiation induced free radicals in PLGA. The gamma irradiation increased the release rate of BCNU from PLGA wafer at applied irradiation doses except 2.5 Mrad of irradiation dose in this study.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. Miyajima, A. Koshika, J. Okada, A. Kusai, and M. Ikida,Int. J. Pharm.,169, 255 (1998).

    Article  CAS  Google Scholar 

  2. G. Khang, J. H. Lee, J. W. Lee, J. C. Cho, and H. B. Lee,Korea Polym. J.,8, 80 (2000).

    CAS  Google Scholar 

  3. J. S. Lee, G. S. Chae, T. K. An, G. Khang, S. H. Cho, and H. B. Lee,Macromol. Res.,11(3), 183 (2003).

    Article  CAS  Google Scholar 

  4. S. A. Seo, H. S. Choi, D. H. Lee, G. Khang, J. M. Rhee, and H. B. Lee,Polymer(Korea),25, 884 (2001).

    CAS  Google Scholar 

  5. H. S. Choi, G. Khang, H. C. Shin, J. M. Rhee, and H. B. Lee,Int. J. Pharm.,234, 195 (2002).

    Article  CAS  Google Scholar 

  6. J. S. Lee, J. H. Shin, J. K. Jeong, J. M. Rhee, H. B. Lee, and G. Khang,Polymer(Korea),27, 9 (2003).

    CAS  Google Scholar 

  7. G. Khang, S. A. Seo, H. S. Choi, J. M. Rhee, and H. B. Lee,Macromol. Res.,10, 246 (2002).

    Article  CAS  Google Scholar 

  8. H. S. Seong, D. S. Moon, G. Khang, and H. B. Lee,Polymer(Korea),26, 128 (2002).

    CAS  Google Scholar 

  9. G. Khang, S. J. Lee, J. H. Lee, Y. S. Kim, and H. B. Lee,Bio-Med. Mater. Eng.,9, 179 (1999).

    CAS  Google Scholar 

  10. G. Khang and H. B. Lee, inMethods of Tissue Engineering, A. Atala and R. Lanza, Eds., Academic Press, London, 2001, Section II, pp 771–797.

    Google Scholar 

  11. S. J. Lee, G. Khang, Y. M. Lee, and H. B. Lee,J. Biomater. Sci., Polym. Ed.,13, 197 (2002).

    Article  CAS  Google Scholar 

  12. G. Khang, J. M. Rhee, J. S. Lee, and H. B. Lee,Polym. Sci. Tech.,12, 4 (2001).

    CAS  Google Scholar 

  13. G. Khang and H. B. Lee,Biomedical Polymer, Korean Chemical Society Press, Munundang, Seoul, Korea, 2001.

    Google Scholar 

  14. G. Khang, J. H. Jeon, J. C. Cho, and H. B. Lee,Polymer(Korea),23, 471 (1999).

    CAS  Google Scholar 

  15. G. Khang, J. H. Jeon, J. C. Cho, J. M. Rhee, and H. B. Lee,Polymer(Korea),23, 861 (1999).

    CAS  Google Scholar 

  16. G. Khang, S. J. Lee, J. H. Jeon, J. H. Lee, and H. B. Lee,Polymer(Korea),24, 869 (2000).

    CAS  Google Scholar 

  17. G. Khang, J. H. Lee, I. Lee, J. M. Rhee, and H. B. Lee,Korea Polym. J.,8, 276 (2000).

    Google Scholar 

  18. G. Khang, M. K. Choi, J. M. Rhee, S. J. Lee, H. B. Lee, Y. Iwasaki, N. Nakabayashi, and K. Ishihara,Korea Polym. J.,9, 107 (2001).

    CAS  Google Scholar 

  19. K. A. Athanasiou, G. G. Niederauer, and C. M. Agrawal,Biomaterials,17, 93 (1996).

    Article  CAS  Google Scholar 

  20. A. Mann, M. Kiefer, and H. Leuenberger,J. Pharm. Sci.,90, 275 (2001).

    Article  CAS  Google Scholar 

  21. C. Tardi, M. Drechsler, K. H. Bauer, and M. Brandl,Int. J. Pharm.,217, 161 (2001).

    Article  CAS  Google Scholar 

  22. A. Pruss, M. Kao, H. Kiesewetter, R. V. Versen, and G. Pauli,Biologicals,27, 195 (1999).

    Article  CAS  Google Scholar 

  23. C. E. Holy, C. Cheng, J. E. Davies, and M. S. Shoichet,Biomaterials,22, 25 (2001).

    Article  CAS  Google Scholar 

  24. L. Chen, R. N. Apte, and S. Cohen,J. Control. Release,43, 261 (1997).

    Article  Google Scholar 

  25. H. S. Seong, D. S. Moon, G. Khang, and H. B. Lee,Macromol. Chem. Symp.,4(3), 95 (2001).

    Google Scholar 

  26. T. K. An, H. J. Kang, D. S. Moon, J. S. Lee, H. S. Seong, J. K. Jeong, G. Khang, and H. B. Lee,Polymer(Korea),26, 670 (2002).

    CAS  Google Scholar 

  27. T. K. An, H. J. Kang, J. S. Lee, H. S. Seong, J. K. Jeong, G. Khang, Y. Hong, and H. B. Lee,Polymer(Korea),26, 691 (2002).

    CAS  Google Scholar 

  28. H. S. Seong, T. K. An, G. Khang, S. Choi, C. O. Lee, and H. B. Lee,Int. J. Pharm.,251, 1 (2003).

    Article  CAS  Google Scholar 

  29. T. K. An, J. S. Lee, P. K. Shin, H. S. Seong, G. Khang, and H. B. Lee,Biomater. Res.,6(4), 135 (2002).

    Google Scholar 

  30. Bristol Laboratories, BiCNU package insert. Syracuse, NY, 1977.

  31. A. G. Hausberger, R. A. Kenley, and P. P. DeLuca,Pharm. Res.,12, 233 (1995).

    Article  Google Scholar 

  32. L. Montanari, F. Cilurzo, L. Valvo, A. Faucitano, A. Buttafava, A. Groppo, I. Genta, and B. Conti,J. Control. Release,75, 317 (2001).

    Article  CAS  Google Scholar 

  33. L. Montanari, M. Costantini, E. C. Signoretti, L. Valvo, M. Santucci, M. Bartolomei, P. Fattibene, S. Onori, A. Faucitano, B. Conti, and I. Genta,J. Control. Release,56, 219 (1998).

    Article  CAS  Google Scholar 

  34. N. Faisant, J. Siepmann, P. Oury, V. Laffineur, E. Bruna, J. Haffner, and J. P. Benoit,Int. J. Pharm.,242, 281 (2002).

    Article  CAS  Google Scholar 

  35. A. Merkli, J. Heller, C. Tabatabay, and R. Gumy,Pharm. Res.,11, 1485 (1994).

    Article  CAS  Google Scholar 

  36. Sterilization and sterility assurance of compendial articles, USP 23/NF 18, United States Pharmacopeial Convention, Inc., Rockville, MD, 1995, pp 1976–1980.

Download references

Author information

Authors and Affiliations

  1. Department of Advanced Organic Materials Engineering, Chonbuk National University, 664-14, Duckjin Gu, 561-756, Jeonju, Korea

    Jin Soo Lee, Gang Soo Chae & Gilson Khang

  2. Biomaterials Laboratory, Korea Research Institute of Chemical Technology, P. O. Box 107, 305-600, Daejeon, Korea

    Moon Suk Kim, Sun Hang Cho & Hai Bang Lee

Authors
  1. Jin Soo Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gang Soo Chae
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gilson Khang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Moon Suk Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sun Hang Cho
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hai Bang Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, J.S., Chae, G.S., Khang, G. et al. The effect of gamma irradiation on PLGA and release behavior of BCNU from PLGA wafer. Macromol. Res. 11, 352–356 (2003). https://doi.org/10.1007/BF03218376

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03218376

Keywords

Search

Navigation