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Preparation and antitumor activities of poly(polyethylene glycol methacrylate-co-methacryloyloxymethyl-5-fluorouracil) prodrug

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Abstract

In order to prepare a prodrug, poly(polyethylene glycol methacrylate-co-methacryloyloxymethyl-5-fluorouracil) (poly(PEGM-co-MAOFU)) prodrug particles were prepared by precipitation polymerization of MAOFU and PEGM in polyacrylic acid solution. The size of prodrug particles were 0.2–0.35 μm. The antitumor activity of prodrugs against sarcoma-180 tumor cell in mice was demonstrated and the polymer particles themselves showed low toxicity and good biocompatibility when they were administrated into mice.

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Authors and Affiliations

  1. Division of High-Tech Material and Eectronics, Hyejeon College, Hongsung-eup, 350-800, Korea

    Suk Hyung Cho

  2. Divison of Chemical Engineering, Chungbuk National University, 360-763, CheongJu, Korea

    Kong Soo Kim

Authors
  1. Suk Hyung Cho
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  2. Kong Soo Kim
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Cho, S.H., Kim, K.S. Preparation and antitumor activities of poly(polyethylene glycol methacrylate-co-methacryloyloxymethyl-5-fluorouracil) prodrug. Macromol. Res. 11, 317–321 (2003). https://doi.org/10.1007/BF03218370

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  • DOI: https://doi.org/10.1007/BF03218370

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