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Gold compounds for rheumatoid arthritis

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Abstract

Auranofin [2,3,4,6-tetra-0-acetyl-1-thio-β-D-glucopyranosato-S)-(triethylphosphine)gold], a new gold compound for treating rheumatoid arthritis (RA), is unique in that it produces its therapeutic benefit when administered by the oral route. Currently used gold preparations (sodium aurothiomalate, aurothioglucose) must be given by injection to be effective. Auranofin has been used in the treatment of RA patients in clinical trials, and is comparable in efficacy to presently used injectable agents. Side effects with auranofin are mild in nature and result in fewer withdrawals from therapy than do injectable gold preparations.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, Smith Kline and French Laboratories, Philadelphia, Pennsylvania, USA

    Blaine M. Sutton

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  1. Blaine M. Sutton
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This article is a slightly revised version of a paper first given at an IPMI conference, June 13th, 1985 and is reprinted by kind permission of the IPMI.

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Sutton, B.M. Gold compounds for rheumatoid arthritis. Gold Bull 19, 15–16 (1986). https://doi.org/10.1007/BF03214639

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  • DOI: https://doi.org/10.1007/BF03214639

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