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Polymorphisms in coding and regulatory regions of the porcineMYF6 andMYOG genes and expression of theMYF6 gene inm. longissimus dorsi versus productive traits in pigs

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Abstract

MYOG andMYF6 belong to theMyoD gene family. They code for the bHLH transcription factors playing a key role in later stages of myogenesis: differentiation and maturation of myotubes. Three SNPs in porcineMYF6 and two in porcineMYOG were analysed in order to establish associations with chosen carcass quality and growth rate traits in Polish Landrace, Polish Large White and line 990 sows. No statistically significant effect of SNP in the promoter region of theMYF6 gene on its expression measured on mRNA level was found. Associations between the genotype at theMYF6 locus and carcass quality traits appeared to be breed-dependent. The C allele in the case of SNP in the promoter region and GC haplotype in exon 1 were advantageous for right carcass side weight in Polish Landrace sows and disadvantageous for this trait in Polish Large White sows. These gene variants were also the most advantageous for loin and ham weight in sows of line 990. The mutation in exon 1 of theMYOG gene had no statistically significant association with carcass quality traits and the mutation in the 3’-flanking region had the breed-dependent effect as well. These results suggest that SNPs analysed in this study are not causative mutations, but can be considered as markers of some other, still unrevealed genetic polymorphism that influences the physiological processes and phenotypic traits considered in this study.

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Authors and Affiliations

  1. Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzębiec, Postępu 1, 05-552, Wólka Kosowska, Poland

    Joanna Wyszyńska-Koko, Mariusz Pierzchała, Krzysztof Flisikowski & Jolanta Kurył

  2. National Institute of Animal Production, Balice, Poland

    Marian Kamyczek & Marian Różycki

Authors
  1. Joanna Wyszyńska-Koko
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  2. Mariusz Pierzchała
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  3. Krzysztof Flisikowski
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  4. Marian Kamyczek
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  5. Marian Różycki
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  6. Jolanta Kurył
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Correspondence to Joanna Wyszyńska-Koko.

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Wyszyńska-Koko, J., Pierzchała, M., Flisikowski, K. et al. Polymorphisms in coding and regulatory regions of the porcineMYF6 andMYOG genes and expression of theMYF6 gene inm. longissimus dorsi versus productive traits in pigs. J Appl Genet 47, 131–138 (2006). https://doi.org/10.1007/BF03194612

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  • DOI: https://doi.org/10.1007/BF03194612

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