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Pharmacokinetics of Astragaloside IV in rats by liquid chromatography coupled with tandem mass spectrometry

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Summary

Pharmacokinetics of Astragaloside IV (AGS-IV) in rats was studied by high performance liquid chromatography coupled with tandem mass spectrometry. The concentration in plasma was determined after iv administration of 1, 2, 4mg/kg and po administration of 20mg/kg of AGS-IV. The AUC were linearly correlated to doses. Recoveries of AGS-IV in bile, urine and feces were also analyzed following iv dose of 2 mg/kg. Cumulative recovery of AGS-IV in bile reached 30.8% in 24h. Cumulative recovery of AGS-IV in urine and feces was 52.14%, which indicates that about 50% of AGS-IV was metabolized in vivo. The bioavailability of AGS-IV after po administration was found to be 3.66%. These findings provide useful information for the research and development of AGS-IV and other potential agents.

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Authors and Affiliations

  1. College of Life and PharmacyΘ§ Nanjing University of Technology, 210009, Nanjing, People’s Republic of China

    Y Du, Q Zhang, Gg Chen, P Wei & Cy Tu

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  1. Y Du
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  2. Q Zhang
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  3. Gg Chen
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  4. P Wei
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  5. Cy Tu
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Du, Y., Zhang, Q., Chen, G. et al. Pharmacokinetics of Astragaloside IV in rats by liquid chromatography coupled with tandem mass spectrometry. European Journal of Drug Metabolism and Pharmacokinetics 30, 269–273 (2005). https://doi.org/10.1007/BF03190631

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  • DOI: https://doi.org/10.1007/BF03190631

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