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Dihydroergosine pharmacokinetic modelling and simulation

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Summary

For this study of dihydroergosine pharmacokinetic modelling and simulation, the data from our paper about3H-DHESN plasma, bile, urine, and faeces concentrations after intravenous and oral administration were used (1). The model obtained with the identified parameters was in agreement within vivo data. Certain special phenomena, such as the enterohepatic cycle and incomplete absorption, were taken into account. Analog-hybrid simulation and identification represents an effective tool for such studies. In spite of the limited validity of the availablein vivo data, the work represents a first step in the introduction of DHESN into human medicine.

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References

  1. Mrhar, A., Kopitar, Z., Kozjek, F., Krusic, L., Lenardic, A. (1983): Pharmacokinetics of dihydroergosine in rats after intravenous and oral administration. European Journal of Drug Metabolism and Pharmacokinetics8, 17–20.

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  2. Mrhar, A., Kopitar, Z., Kozjek, F., Presl, V., Karba, R. (1979): Clinical pharmacokinetics of nitroxoline. Int. J. clin. Pharmacol. Biopharm.,17, 476–481.

    CAS  Google Scholar 

  3. Karba, R., Bremsak, F., Matko, D., Mrhar, A., Kozjek, F. (1978): Pharmacokinetical models development and identification. Preprints of the Seventh Triennial World Congress of the IFAC, Helsinki, Finland,1, 557–564.

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  4. Karba, R., Mrhar, A., Kozjek, F., Bremsak, F. (1979): Appropriate nitroxoline dosage regimen design. Int. J. clin. Pharmacol Biopharm.,17, 482–485.

    CAS  PubMed  Google Scholar 

  5. Karba, R., Bremsak, F., Kozjek, F., Mrhar, A., Matko, D. (1979): Hybrid simulation in drug pharmacokinetics. Preprints of the IMACS Congress, Sorrento, Italy, 733–741.

  6. Eykhoff, P. (1974): System identification, Wiley, London.

    Google Scholar 

  7. Wagner, J.G. (1971): Biopharmaceutics and Relevant Pharmacokinetics, Drug Intelligence Publication, Hamilton.

    Google Scholar 

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Authors and Affiliations

  1. Faculty of Electrical Engineering, University Edvard Kardelj Ljubliana, Trzaska 25, 61000, Ljubljana, Yugoslavia

    R. Karba & F. Bremsak

  2. Department of Pharmacy, University Edvard Kardelj Ljubljana, Yugoslavia

    A. Mrhar & F. Kozjek

  3. Research Institute Lek, Pharmaceutical and Chemical Works Ljubljana, Yugoslavia

    Z. Kopitar & A. Lenardic

Authors
  1. R. Karba
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  2. A. Mrhar
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  3. F. Kozjek
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  4. F. Bremsak
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  5. Z. Kopitar
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  6. A. Lenardic
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Karba, R., Mrhar, A., Kozjek, F. et al. Dihydroergosine pharmacokinetic modelling and simulation. European Journal of Drug Metabolism and Pharmacokinetics 8, 21–23 (1983). https://doi.org/10.1007/BF03189577

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  • DOI: https://doi.org/10.1007/BF03189577

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