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The metabolism of nicotine in cigarette smokers during pregnancy

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Summary

The urinary excretion of nicotine and its metabolites, nicotine-l’-N-oxide and cotinine, were determined for 40 pregnant and 30 non-pregnant smokers. The pregnant subjects participated in a longitudinal study over their last trimester in order to describe variations in nicotine metabolism with gestational age. No significant relationship was found between the level of excretion of the nicotine metabolites and infant birthweight for the pregnant smokers; nor was evidence found for the preferential accumulation of cotinine compared to nicotine-l’-N-oxide for pregnant compared to non-pregnant smokers. The longitudinal study demonstrated a significant drop in the nicotine-l’-N-oxide excretion level over the 29th to the 32nd weeks of gestation for all six subjects examined over this period.

Tests demonstrated that this decrease in the nicotine-l’-N-oxide level was not due to an unusual decomposition effect in the urine.

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References

  1. Davies D.P., Gray O.P., Ellwood P.C. and Abernethy M. (1976): Cigarette smoking in pregnancy: Associations with maternal weight gain and fetal growth. Lancet,1, 385–387.

    Article  CAS  PubMed  Google Scholar 

  2. Rush D. (1974): Examination of the relationship between birth weight, cigarette smoking during pregnancy and maternal weight gain. J. Obst. and Gynacol. of Brit. Commonwealth,81, 746–752.

    CAS  Google Scholar 

  3. Simpson W.J. (1957): A preliminary report on cigarette smoking and the incidence of prematurity.Am. J. Obs., 73, 808–815.

    Google Scholar 

  4. Rush D. and Kass E.H. (1972): Maternal smoking: a reassessment of the association with perinatal mortality.Am. J. of Epiderm, 96, 183–196.

    CAS  Google Scholar 

  5. Larson P.S., Haag H.B. and Silvette H. (1961): InTobacco, Experimental and Clinical Studies. Williams and Wilkins Co., Baltimore.

    Google Scholar 

  6. Beckett A.H., Gorrod J.W. and Jenner P. (1971a): The effect of smoking on nicotine metabolismin vitro in humans.J. Pharm. Pharmac., 23, 62–67.

    Google Scholar 

  7. Gorrod J.W. and Jenner P. (1975): InEssays in Tixocology, 6, Ed. by Hayes W.J. Academic Press, New York.

    Google Scholar 

  8. Gorrod J.W., Jenner P., Keysell G. and Beckett A.H. (1971): Selective inhibition of alternative oxidative pathways of nicotine metabolismin vitro.Chem.-Biol, Interact, 3, 269–270.

    Article  CAS  Google Scholar 

  9. Gorrod J.W., Jenner P., Keysell G.R. and Mikhael B.R. (1974): Oxidative metabolism of nicotine by cigarette smokers with cancer of the urinary bladder.J. Nat. Cancer Inst., 52, 1421–1424.

    CAS  PubMed  Google Scholar 

  10. Dean M.E. and Stock B.H. (1975): Hepatic microsomal metabolism of drugs during pregnancy in the rat.Drug Metab. Disp., 3, 325–331.

    CAS  Google Scholar 

  11. Tjalve H., Hansson E. and Schmiterlow C.G. (1965): Passage of14C-Nicotine and its metabolites into mice foetuses and placentae.Acta Pharmac. Toxical, 26, 539–555.

    Google Scholar 

  12. Fabro S. (1973): InFetal Pharmacology. Ed. by L. Boreus. Raven Press, New York.

    Google Scholar 

  13. Beckett A.H. and Triggs E.J. (1966): Determination of nicotine and its metabolite, cotinine, in urine by gas chromatography.Nature, 211, 1415–1417.

    Article  CAS  PubMed  Google Scholar 

  14. Beckett A.H., Gorrod J.W. and Jenner P. (1971b): The analysis of nicotine-l’-N-oxide in urine, in the presence of nicotine and cotinine, and its applications to the study of in vivo nicotine metabolism in man.J. Pharm. Pharmac., 23, 55S-61S.

    CAS  Google Scholar 

  15. Taylor E.C. and Boyer N.E. (1959): Pyridine-1 -oxides. IV. Nicotine-1-oxide, nicotine-1’oxide and nicotine-1,1’-oxide.J. Org. Chem., 24, 275–277.

    Article  CAS  Google Scholar 

  16. Bowman E.R. and McKennis Jr. H. (1959): (−)-Cotinine.Biochem. Prep., 10, 31–33.

    Google Scholar 

  17. Haag H.B. and Larson P.S. (1942): Studies on the fate of nicotine in the body I. The effect of pH on the urinary excretion of nicotine by tobacco smokers.J. Pharm. Exp. Ther., 76, 235–239.

    CAS  Google Scholar 

  18. Zabriskie J.R. (1963): Effect of cigarette smoking during pregnancy. Study of 2,000 cases.Obst. Gyn., 21, 405–411.

    CAS  Google Scholar 

  19. Hobkirk R., Blahey P.R., Alfheim A., Raeside J.I. and Joron G.E. (1960): Urinary estrogen excretion in normal and diabetic pregnancy.J. Clin. Endo. Metab., 20, 805–813.

    Article  CAS  Google Scholar 

  20. Hughes E.C., Lloyd C.W., Jones D., Lobotsky J., Rienzo J.S. and Avery G.M. (1954): Some recent observations concerning the toxemias of pregnancy.Amer. J. Obs. and Gynacol., 67, 782–800.

    CAS  Google Scholar 

  21. Whitfield C.R., Chan W.H., Sproule W.B. and Stewart A.D. (1972): Amniotic fluid lecithin: Sphingomyelin ratio and fetal lung development.Brit. Med. J., 2, 85–86.

    Article  CAS  PubMed  Google Scholar 

  22. Skryten A., Johnson P., Samside G. and Gustafson A. (1976): Studies in diabetic pregnancy. I. Serum lipidsActa Obstret. Gynacol., 55, 211–215.

    Article  CAS  Google Scholar 

  23. Robinson D.S. (1970): InComprehensive Biochemistry, 18, Ed. by Florkin M. and Stotz E.H., Elsevier, Amsterdam.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacy, Chelsea College, University of London, Manresa Road, SW3 6LX, London, U.K.

    A. E. Klein & J. W. Gorrod

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  1. A. E. Klein
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  2. J. W. Gorrod
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Klein, A.E., Gorrod, J.W. The metabolism of nicotine in cigarette smokers during pregnancy. European Journal of Drug Metabolism and Pharmacokinetics 3, 87–93 (1978). https://doi.org/10.1007/BF03189375

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  • DOI: https://doi.org/10.1007/BF03189375

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