Summary
The pharmacokinetics of vincamine were studied in dogs by a specific and convenient analytical method which may be applicable to clinical pharmacokinetic studies in man. Experimental data were consistent with a two-compartment open model but the existence of a third compartment might be suspected because of the longer T 1/2/β, i.e., 4.5 h compared with 0.5 to 1.5 h in man. Complete pharmacokinetical parameters of vincamine in dogs were also given with emphasis on apparent volume of distribution (VD) which has frequently given rise to discrepancies in the literature.
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Moulin, M.A., Kinsun, H. & Bigot, M.C. Pharmacokinetical parameters of vincamine in dog. European Journal of Drug Metabolism and Pharmacokinetics 3, 73–77 (1978). https://doi.org/10.1007/BF03189373
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DOI: https://doi.org/10.1007/BF03189373