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Role of FGF-2/FGFR signaling pathway in cancer and its signification in breast cancer

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Chinese Science Bulletin

Abstract

Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. It has been proved that FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis). However, many of the biological activities of FGF-2 have been found to depend on its receptor’s intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. This review will focus on the mechanism of FGF-2/FGFR induced signaling pathway in tumor and human breast cancer.

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Authors and Affiliations

  1. Institute of Biophyscis & Biochemistry of Huazhong University of Science & Technology, 430074, Wuhan, China

    Jianwu Fang, Siluo Huang, Huisheng Liu, Tao Xu & Jianfeng Liu

  2. CNRS-UPR 9023 Mecanismes Moleculaires des Communications CellulairesCCIPE, 34090, France

    Jianfeng Liu

  3. Laboratoire de Recherche Oncologie MoleÂculaire Humaine (EA 445), UFR LeÂonard de Vinci, Universite Paris-nord, 74, rue Marcel Cachin, 93012, Bobigny, France

    M. Crepin

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  1. Jianwu Fang
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  2. Siluo Huang
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  4. M. Crepin
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  5. Tao Xu
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Correspondence to Jianfeng Liu.

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Fang, J., Huang, S., Liu, H. et al. Role of FGF-2/FGFR signaling pathway in cancer and its signification in breast cancer. Chin. Sci. Bull. 48, 1539–1547 (2003). https://doi.org/10.1007/BF03183956

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  • DOI: https://doi.org/10.1007/BF03183956

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