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Stem cell transplantation for thalassemia

  • Asian Cooperation in the Field of Hematology
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Abstract

Thalassemia, one of the most common genetic disorders, is considered to be a global problem. Several millions of the patients suffer from severe thalassemic diseases. Stem cell transplantation is currently the only curative therapy. Bone marrow transplantation offers a high probability of cure when performed in young children. There is a higher risk as the patient becomes older, especially the high incidence of graft rejection. Modified conditioning regimens have been developed to overcome graft rejection in patients with class III or full blown manifestations. The alternative use of stem cell from cord blood makes possible earlier transplant with better chance of cure, although the engraftment is slower compared to bone marrow transplantation. More experiences with regard to stem cell transplantation in adult patients, the use of stem cell transplantation from related donors as well as matched unrelated donors are necessary.

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Authors and Affiliations

  1. Division of Hematology and Chulabhorn Bone Marrow Transplant Center, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Surapol Issaragrisil

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  1. Surapol Issaragrisil
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Issaragrisil, S. Stem cell transplantation for thalassemia. Int J Hematol 76 (Suppl 1), 307–309 (2002). https://doi.org/10.1007/BF03165269

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  • DOI: https://doi.org/10.1007/BF03165269

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