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18F-fluorodeoxyglucose-PET and99mTc-bicisate-SPECT in Creutzfeldt-Jakob disease

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Abstract

In a patient with the occipitoparietal form of Creutzfeldt-Jakob disease (CJD) (Heidenhain type) positron emission tomography (PET) demonstrated decreased glucose utilization in the occipital lobes and adjacent cortical regions. Single photon emission computed tomography (SPECT) with99mTc-bicisate showed a “coupled” decrease in blood flow in identical cortical areas in this patient. In contrast, magnetic resonance imaging (MRI) was normal. In the early stage of CJD, when still no major morphological abnormalities can be observed, functional imaging is useful for differential diagnosis, particularly to exclude other causes of dementia or pathological EEG patterns.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany

    Frank Grünwald, Hans Bender, Christian Menzel, Jürgen Ruhlmann & Hans-Jürgen Biersack

  2. Department of Neurology, University of Bonn, Bonn, Germany

    Christoph Pohl & Alexander Hartmann

  3. Department of Radiology, University of Bonn, Bonn, Germany

    Ewald Keller

Authors
  1. Frank Grünwald
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  2. Christoph Pohl
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  3. Hans Bender
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  4. Alexander Hartmann
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  5. Christian Menzel
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  6. Jürgen Ruhlmann
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  7. Ewald Keller
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  8. Hans-Jürgen Biersack
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Grünwald, F., Pohl, C., Bender, H. et al. 18F-fluorodeoxyglucose-PET and99mTc-bicisate-SPECT in Creutzfeldt-Jakob disease. Ann Nucl Med 10, 131–134 (1996). https://doi.org/10.1007/BF03165066

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  • DOI: https://doi.org/10.1007/BF03165066

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