Abstract
To evaluate the usefulness of FDG-PET as a predictor of prognosis, 34 patients with untreated malignant lymphoma in the head and neck region were studied. After FDG-PET and treatment, they were observed from 15 to 50 months. Tumors which were aggressive and resistant to treatment tended to show high uptake of FDG. The survival rate of patients with high uptake of FDG, DAR > 8, was lower than the rate of the other patients. It is considered to be useful to add FDG uptake of the tumor to other prognostic factors for predicting the prognosis.
Similar content being viewed by others
References
Okada J, Yoshikawa K, Imazeki K, Minoshima S, Uno K, Itami J, et al. The use of FDG-PET in the detection and management of malignant lymphoma: Correlation of uptake with prognosis.J Nucl Med 32: 686–691, 1991.
Okada J, Yoshikawa K, Itami M, Imaseki K, Uno K, Itami J, et al. Positron emission tomography using fluorine-18-fluorodeoxyglucose in malignant lymphoma: A comparison with proliferative activity.J Nucl Med 33: 325–329, 1992.
Schrape S, Jones DB, Wright DH. A comparison of three methods for the determination of the growth fraction in non-Hodgkin’s lymphoma.Br J Cancer 55: 283–286, 1987.
Hall PA, Richards MA, Gregory WM, d’Ardenne AJ, Lister TA, Stansfeld A. The prognostic value of Ki-67 immunostaining in non-Hodgkin’s lymphoma.J Pathol 1554: 223–235, 1988.
Kern KA, Brunetti A, Norton JA, et al. Metabolic imaging of human extremity musculoskeletal tumors by PET.J Nucl Med 29: 181–186, 1988.
Griffeth LK, Dehdashti F, Mcguire AH, et al. PET evaluation of soft-tissue masses with fluorine-2-deoxy-Dglucose.Radiology 182: 185–194, 1992.
Okazumi S, Isono K, Enomoto K, et al. Evaluation of liver tumors using fluorine-18-fluorodeoxy glucose PET: characterization of tumor and assessment of effect of treatment.J Nucl Med 33: 333–339, 1992.
Gritters LS, Francis IR, Zasadny KR, Wahl RL. Initial assessment of positron emission tomography using 2-fluorine-18-fluoro-2-deoxy-D-glucose in the imaging of malignant melanoma.J Nucl Med 34: 1420–1427, 1993.
Leskinen-Kallio S, Ruotsalainen U, Nagren K, Teraes M, Joensusu H. Uptake of carbon-11-methionine and fluorodeoxyglucose in non-Hodgkin’s lymphoma: a PET study.J Nucl Med 32: 1211–1218, 1991.
Patronas NJ, Di Chiro G, Kufta C, et al. Prediction of survival in glioma patients by means of positron emission tomography.J Neurosurg 62: 816–822, 1985.
National Cancer Institute. Study of classifications on non-Hodgkin’s lymphomas: summary and description of a working formulation for clinical usage.Cancer 49: 2112–2135, 1982.
Fukuda M, Matuzawa T, Ito M. Clinical evaluation of cancer diagnosis with 18F-2-fluoro-D-glucose. Its usefulness in liver and pancreas cancers.CYRIC Annual Report, Tohoku University, pp. 244–250, 1983.
Kaplan EL, Meier P. Nonparametric estimation from incomplete observations.J Am Stat Assoc 53: 457–481, 1958.
Cox DR. Regression models and life tables.J Royal Stat Soc Series B 34: 187–229, 1972.
Patlak CS, Blasberg RG, Frenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data.J Cereb Blood Flow Metab 3: 1–7, 1983.
Gjedde A, Wienhard K, Heiss WD, et al. Comparative regional analysis of 2-fluorodeoxyglucose and methylglucose uptake in brain of four stroke patients with special reference to the regional estimation of the lumped constant.J Cereb Blood Flow Metab 5: 163–178, 1985.
Wienhard K, Pawlik G, Herholz K, Wagner R, Heiss WD. Estimation of local cerebral glucose utilization by positron emission tomography of [18F]2-fluoro-2-deoxy-D-glucose: a critical appraisal of optimization procedures.J Cereb Blood Flow Metab 5: 115–125, 1985.
Fischman AJ, Alpert NM. FDG-PET in oncology: There’s more to it than looking at pictures.J Nucl Med 34: 6–11, 1993.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Okada, J., Oonishi, H., Yoshikawa, K. et al. FDG-PET for predicting the prognosis of malignant lymphoma. Ann Nucl Med 8, 187–191 (1994). https://doi.org/10.1007/BF03164996
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03164996