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Early and delayed Tc-99m-tetrofosmin myocardial SPECT in patients with left bundle branch block

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Abstract

To determine the utility of the myocardial tracer Tc-99m-tetrofosmin in the examination of patients with left bundle branch block (LBBB) and to investigate Tc-99m-tetrofosmin uptake and retention in the myocardium, early and delayed Tc-99m-tetrofosmin SPECT was performed in 10 patients having LBBB without coronary stenosis.Methods: After 740 MBq of Tc-99m-tetrofosmin injection in the resting state, the early and delayed SPECT imaging was done at 30 min and 180 min, respectively.Results: Decreased Tc-99m-tetrofosmin uptake in the septal segments was observed in 4 patients (40%) at 30 min and in 9 (90%) at 180 min. Reverse redistribution was seen in 9 of 10 patients. In patients with LBBB, the septal-to-lateral uptake ratio was lower in the delayed images than in the early images (0.80 ± 0.09 vs. 0.89 ± 0.09, p < 0.001). In patients with LBBB, the washout rate of Tc-99m-tetrofosmin was higher in the septal segments than in the lateral segments (28.3 ±4.3% vs. 22.8 ± 3.3%, p < 0.001).Conclusion: The SPECT data indicate that in LBBB without coronary stenosis, the uptake of Tc-99m-tetrofosmin is decreased in the septal wall, and that reverse redistribution occurs frequently. Our results contribute to the elucidation of both the cellular biokinetics of Tc-99m-tetrofosmin in the myocardium and the hemodynamics of the septum in LBBB, and indicate the possible clinical utility of Tc-99m-tetrofosmin.

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Authors and Affiliations

  1. Department of Radiology, Kyoto Prefectural University of Medicine, Kajiicho, Kawaramachi Hirokoji, Kamigyo-ku, 602-0841, Kyoto, Japan

    Hiroki Sugihara, Yo Ushuima & Tomoho Maeda

  2. Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan

    Noriyuki Kinoshita, Yoshihiko Adachi, Yoko Taniguchi, Katsuichi Ohtsuki, Akihiro Azuma, Haruhiko Adachi & Masao Nakagawa

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  1. Hiroki Sugihara
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  2. Noriyuki Kinoshita
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  4. Yoko Taniguchi
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  6. Akihiro Azuma
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  7. Haruhiko Adachi
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  8. Yo Ushuima
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  9. Masao Nakagawa
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  10. Tomoho Maeda
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Sugihara, H., Kinoshita, N., Adachi, Y. et al. Early and delayed Tc-99m-tetrofosmin myocardial SPECT in patients with left bundle branch block. Ann Nucl Med 12, 281–286 (1998). https://doi.org/10.1007/BF03164914

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  • DOI: https://doi.org/10.1007/BF03164914

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