Zusammenfassung
□ Die Duplexsonographie ermöglicht die Beurteilung der Hämodynamik des gesamten portalvenösen und Lebervenengefäßsystems. Die Methode ist etabliert als „noninvasive Splenoportographie” und hat einen hohen diagnostischen Rang durch frühzeitigen und schnellen Nachweis von Pfortader- und Milzvenenthrombosen, dem Budd-Chiari-Syndrom, der Darstellung portosystemischer Kollateralen und Veränderungen der Strömungsrichtung in der Pfortader.
□ Neben diesen qualitativen Befunden gewinnt die quantitative Duplexsonographie durch Ermittlung der portalvenösen Blutströmungsgeschwindigkeit zur Abschätzung der portalen Hypertonie und des Blutungsrisikos aus Ösophagusvarizen zunehmende klinische Bedeutung. Daneben liefert sie wertvolle Hinweise in der Therapieüberwachung der medikamentösen Blutungsprophylaxe.
□ Zur Verlaufskontrolle nach portokavalen Shunt-Operationen und intrahepatischer Stent-Einlage eignet sich das Verfahren ebenso wie zur Diagnose vaskulärer Transplantatdysfunktionen. Darüber hinaus erlangt die Duplexsonographie klinische Bedeutung in der Diagnose und Therapiekontrolle akuter Lebertransplantatabstoßungen.
□ Bei der Tumordiagnostik liegt ihr Wert im präoperativen Staging, sie liefert außerdem differentialdiagnostische Hinweise anhand von Perfusionsmustern.
Abstract
□ Duplex ultrasound allows direct access to portal venous and hepatic vein hemodynamics. This method has been accepted as a reliable procedure to detect portal and splenic venous thrombosis, Budd-Chiari’s syndrome, portosystemic collateralisation and changes in the portal venous blood flow direction with a high rate of sensitivity.
□ Besides these qualitative findings Doppler flowmetry allows quantitative measurement of portal venous blood flow velocities. The estimation of portal hypertension and the prediction of the risk of variceal bleeding by quantitative Doppler flowmetry is of increasing clinical importance. In monitoring the efficiency of medicational prophylaxis against gastrointestinal bleeding is also helpful.
□ Duplex ultrasound can be used to evaluate the function of portocaval shunts including the intrahepatic stent shunt as well as to detect vascular complications after liver transplantation. Furthermore the method is gaining importance in the diagnosis and monitoring of therapy of acute liver transplant rejection.
□ In case of liver tumors duplex ultrasound is of value for tumor staging and provides information about the dignity on the basis of perfusion patterns.
Literatur
Alpern MB, Rubin JM, Williams DM, Capek P: Porta hepatis: Duplex doppler US with angiographic correlation. Radiology 1987;162:53–6.
Barbara L. Consensus Conference “The value of Doppler US in the study of hepatic hemodynamics” J Hepatol 1990;10:353–5.
Benoit JN, Womack WA, Hernandez L. “Forward” and “backward” flow mechanisms of portal hypertension. Relative contributions in the rat model of portal vein stenosis. Gastroenterology 1985;89:1092–6.
Bolognesi M, Sacerdoti D, Merkel C, Caregaro L, Bellon S, Gatta A. Duplex Doppler ultrasonography allows a multiorgan noninvasive approach to splanchnic pharmacodynamics in patients with cirrhosis. Imaging 1995;62:138–43.
Bolondi L, Gaiani S, Barbara L. Accuracy and reproducity of portal flow measurement by Doppler. J Hepatol 1991;13:269–23.
Bolondi L, Gaiani S, Barbara L. Doppler flowmetry: clinical application in portal hypertensive patients. In: Okuda K, ed. Portal hypertension. Clinical and physiological aspects. New York: Springer, 1991.
Bolondi L, Gaiani S, LiBassi S, Zironi G, Santi V, Benzi G, Barbara L. Changes in the hepatic vein waveform detected by Doppler US in liver cirrhosis. J Hepatol.
Bolondi L, Gaiani S, Mazziotti A, et al. Morphological and hemodynamic changes in the portal venous system after distal splenorenal shunt: an ultrasound and pulsed Doppler study. Hepatology 1988;8:652–7.
Bolondi L, Gaiani S, Zironi G, et al. Doppler US flowmetry in patients with liver cirrhosis. Relation to esophageal varices. Hepatology 1990;10:A 4735.
Brown BP, Abu-Yousef M, Farmer R, La Breque R, Gingrich R. Doppler sonography: a noninvasive method for evaluation of hepatic venoocclusive disease. Am J Roentgenol 1990;154:721–4.
Bru C, Bosch J, Navasa M, Bianchi L, Gilambert R, Rodes J. Pulsed-Doppler measurements of portal blood flow in man: Application in the noninvasive evaluation of pharmacological therapy of portal hypertension. In: Bondestam S, Alanen. A, Jouppilla P, eds. Proceedings of the 6th Congress of the European Federation of Societies for Ultrasound in Medicine and Biology, Helsinki, Finland, June 14–18, 1987.
Coulden RA, Britton PD, Farman P, Noble-Jamison G. Pretiminary report: hepatic vein doppler in the early diagnosis of acute liver transplant rejection. Lancet 1990;336: 273–6.
Evans RG. Doppler sonographic imaging of the vascular system. JAMA 199x;265:2382–7.
Flint EW, Sumkin JH, Zajko AB, Brown A. Duplex sonography of hepatic artery thrombosis after liver transplantation. Am J Roentgenol 1988;151:483–8.
Fujimoto M, Moriyasu F, Nishikiwa K, Takayuki N, Okuma M. Color Doppler sonography of hepatic tumors with a galactose-based contrast agent: Correlation with angiographic findings. Am J Roentgenol 1994;163:1099–104.
Gaiani S, Bolondi L, LiBassi S, Santi V, Zironi G, Barbara L. Effect of meal on portal hemodynamics and in patients with chronic liver disease. Hepatology 1989;9:815–9.
Gaiani S, Bolondi L, LiBassi S, Zironi G, Siringo S, Barbara L. Prevalence of spontaneous hepatofugal portal flow in liver ciirhosis. Gastroenterology 1991;100: 160–7.
Garcia-Pagnan JC, Navasa M, Bosch J, Bru C, Pizcueta P, Rodes J. Enhancement of portal pressure reduction by the association of isosorbide-5-mononitrate to propanolol plus isosorbide dinitrate in portal hypertensive patients: Long term hemodynamic and renal effects. Hepatology 1993;18:447–453.
Grace ND. Prevention of inital variceal hemorrhage. Gastroenterol Clin North Am 1992;21:149–61.
Grant E, Perella R, Gomes AS, et al. Color doppler imaging of portosystemic shunts. Am J Roentgenol 1991;154:393–7.
Grant E, Perella R, Tessler FN, Lois J, Busottil R. Budd-Chiari syndrome: the results of duplex and color Doppler imaging. Am J Roentgenol 1992;158:377–81.
Harms J, Ringe B, Pichlmayr R. Postoperative liver allograft dysfunction: The use of quantitative duplex Doppler signal analysis in adult liver transplant patients. Imaging 1995;62:124–31.
Henning J, Müri M, Brunner P. Quantitative flow measurement with the Fourier flow technique. Radiology 1988;166:237–40.
Herbetko J, Grigg AP, Buckley AR, Phillips GL. Venoocclusive liver disease after bone marrow transplantation: findings at duplex sonography. Am J Roentgenol 1992;158: 1001–5.
Hosoki T, Kuroda C, Tokunaga K, Marukawa T, Masuike M, Kozuka T. Hepatic venous outflow obstruction: evaluation with pulsed Doppler sonography. Radiology 1989;170:733–7.
Kinoshita H, Sakai K, Kubo S. Measurement of human portal blood flow by continous thermodilution. J Surg Res 1989;46:235–40.
Kubale R. Diagnostik von fokalen Leberläsionen. In: Wolf KJ, Fobbe F, Hrsg. Farbkodierte Duplexsonographie. Stuttgart-New York: Thieme, 1983:178–80.
Lafortune M, Marlinet P, Deuyst J. Short and long-term hemodynamic effects of transjugulär intrahepatic portosystemic shunts. A Doppler/manometric correlative study. Am J Roentgenol 1995;164:611–7.
Leen E, Goldberg JA, Robertson J, et al. Detection of hepatic metastases using duplex/color Doppler sonography. Ann Surg 1991;214:599–604.
Longo JM, Bilbao JI, Rousseau HP, et al. Color doppler guidance in transjugular placement of intrahepatic portosystemic shunt. Radiology 1994;184:281–3.
Matsutani S, Furuse J, Ishii M, Mizumoto L, Kimura K, Ohta M. Hemodynamics of the left gastric vein in portal hypertension. Gastroenterology 1993;105:513–8.
Mohr HH, Gödderz W, Gerken G, Meyer zum Büschenfelde KH. Protektiver Einfluß spontaner portosystemischer Shunts auf Varizengröße/-blutung. Endoskopie heute 1995;1:99.
Mohr HH, Gödderz W, Große A, Gerken G, Meyer zum Büschenfelde KH. Duplexsonographic investigation of the pathogenesis of splenic hemodynamics in cirrhosis of the liver. Dtsch Med Wochenschr 1996;121:52–6.
Mohr HH, Gödderz W, Lohse A, Gerken G, Meyer zum Büschenfelde KH. Duplex ultrasound in diagnosis and monitoring of liver transplant rejection. Lancet 1995; 346:315–6.
Mohr HH, Gödderz W, Pascher E, Gerken G, Meyer zum Büschenfelde KH. Quantitative Dopplersonographie in der Diagnostik der portalen Hypertension. Z Gastroenterol 1996;34:96.
Moneta GL, Taylor DC, Helton WS, Muhholland MW, Strandness DE. Duplex ultrasound measurement of postprandial intestinal blood flow: Effect of meal composition. Gastroenterology 1988;95:1294–301.
Moriyasu F, Ban N, Nishida O, et al. Quantitative measurement of portal blood flow in patients with chronic liver disease using an ultrasonic system consisting of a pulsed doppler flowmeter and B-mode electroscanner. Gastroenterologica Jpn 1984;19:529–84.
Moriyasu F, Ban N, Nishida O, et al. Clinical application of an ultrasound duplex system in the quantitative measurement of portal flow. J Clin Ultrasound 1986;14:579–84.
Moriyasu F, Nishida O, Ban N, et al. “Congestion Index” of the portal vein. Am J Radiol 1986;146:735–9.
Moriyasu F, Nishida O, Ban N, et al. Ultrasonic Doppler duplex study of hemodynamic changes from portosystemic shunt operation. Ann Surg 1987;205:151–6.
Mostbeck GH, Wittich CR, Herold C, et al. Hemodynamic significance of the paraumbilical vein in portal hypertension: assessment with duplex US. Radiology 1989;170:339–42.
Ohnishi K, Nomura F: Ultrasonic Doppler studies of hepatocellular carcinoma and comparison with other focal lesions. Gastroenterology 1989;97:1489–97.
Ohnishi K, Saito M, Koen H, Nakayama T, Nomura F, Okuda K. Pulsed doppler flow as a criterion of portal venous velocity: Comparison with cineangiographic measurements. Radiology 1985;154:495–8.
Ohnishi K, Saito M, Nakamaya T, et al. Portal venous hemodynamics in chronic liver disease: Effects of posture change and exercise. Radiology 1985;155:557–61
Ohnishi K, Saito M, Sato S, et al. Clinical and portal features in cirrhotics patients having a large spontaneous splenorenal and/ or gastrorenal shunt. Am J Gastroenterol 1986;81:450–5.
Ohnishi K, Saito M, Sato S, et al. Direction of splenic venous flow assessed by pulsed Doppler flowmetry in patients with a large splenorenal shunt. Gastroenterology 1985;89:180–5.
Ohta M, Hashizume M, Tomkawa M, Keno K, Tanone K, Sugimachi K. Analysis of hepatic vein waveforms by Doppler ultrasonography in 100 patients with portal hypertension. Am J Gastroenterol 1994;89:170–5.
Ozaki CF, Anderson JC, Liebermann RC: Duplex ultrasonography as a noninvasive technique for assesing portal hemodynamics. Am J Surg 1988;155:70–5.
Ralls PW, Johnson MB, Lee KP, Radin DR, Halls J. Color Dopplersonography in hepatocellular carcinoma. Am J Physiol Imag 1991;6:57–61.
Rice S, Lee KP, Johnson MB, Korula J, Ralls PW. Portal venous system after portosystemic shunts or endoscopic sclerotherapy: evaluation with Doppler sonogaphy. Am J Roentgenol 1991;156:79–83.
Rössle M, Haag K. Interventional treatment of portal hypertension. Dig Dis 1992;10:Suppl 1:94–102.
Sabba C, Ferraioli G, Buonamico P, et al. Echo doppler evaluation of acute flow changes in portal hypertensive patients: flow velocity as a reliable parameter. J Hepatol 1992;15:356–60.
Sabba C, Merkel C, Zoli M, et al. Interobserver and interequipment variability of echo-doppler examination of the portal vein: effect of a cooperative training program. Hepatology 1995;21:428–33.
Sabba C, Weltin GG, Cicchetti DV, et al. Observer variability in echo-doppler measurements of portal flow in cirrhotic patients and normal volunteers. Gastroenterology 1990;98:1603–10.
Schmassmann A, Zuber M, Livers M, Jäger K, Jenzer HR, Fehr HF: Recurrent bleeding after variceal hemorrhage. Predictive value of portal venous duplex sonography. Am J Roentgenol 1993;160:41–7.
Schwarz KQ, Becher H, Schimpfky C, Vorwerk D, Bogdahn U, Schlief R. Doppler enhancement with SH U 508 A (Levovist®) in multiple vascular regions. Radiology 1994;193:195–201.
Schwerk WB, Restrepo IK. Doppler US detection of increased renal vascular resistance in patients with hepatic cirrhosis. Gastroenterology 1994;106:A979.
Seitz K, Wermke W. Portal hypertension — ultrasound sonography, state of the art. Z Gastroenterol 1995;33: 349–61.
Sherlock S. Diseases of the liver and biliary system. 7th edn. Oxford: Blackwell, 1885.
Staritz M. Correlation of portal hemodynamics (Duplexsonography) with intravariceal pressure and hepatic venous pressure. In: Albano O, ed. International Symposium on Systemic and Regional Hemodynamics in Liver Disease, Bari, 1990.
Tanaka S, Kitamura T, Fujita M, Kasugai H, Inoe A, Ishiguro S. Small hepatocellular carinoma: differation from adenomatous hyperplastic nodule with Doppler flow imaging. Radiology 1992;182:161–5.
Tanaka S, Kituamura T, Fujita M, Nakanishi K, Okuda S. Color Doppler flow imaging of liver tumors. Am J Roentgenol 1990;154:509–14.
Taylor KJW, Morse SS, Weltin GG, Riely CA. Liver transplant recipients: Portable duplex US with correlative angiography. Radiology 1986;159:357–63.
Taylor KJW, Ramos I, Carter D, Morse SS, Snower D, Fortune KL. Correlation of Doppler US tumor signals with neovascular morphologic features. Radiology 1988;166:57–62.
Taylor KJW, Ramos I, Morse SS, Fortune KL, Hammers L, Taylor CR. Focal liver masses: differential diagnosis with pulsed Doppler US. Radiology 1987;164:643–7.
Vorobioff J, Picabea E, Gamen M, et al. Propanolol compared with propanolol plus isosorbide dinitrate in portal hypertensive patients: Long term hemodynamic and renal effects. Hepatology 1993;18:447–52.
Wachsberg RH, Simmons MZ. Coronary vein diameter and flow direction in patients with portal hypertension-evaluation with duplex sonography and correlation with variceal bleeding. Am J Roentgenol 1994;162:637–44.
Wedel S, Beyer A, Fleischmann R, et al. Duplex sonography as compared to other tests in predicting variceal bleeding in advanced cirrhosis of the liver. Gastroenterology 1994;106:A1005.
Wozney P. Vascular complications after liver transplantation. Am J Radiol 1986;147:657–63.
Wruck U. Sonomorphometrische und dopplersonographische Untersuchungen bei chronischen Lebererkrankheiten. Habil.-Schrift, Humboldt-Universität zu Berlin 1990.
Zironi G, D. Gaiani, A. Fenyves, L. Rigamonti, L. Bolondi, L. Barbara: Value of the measurement of mean portal velocity by doppler flowmetry in the diagnosis of portal hypertension. J Hepatol 1992;16:298–303.
Zoli M, Marchesini G, Brunori A, Cordiani MR, Pisi E. Portal venous flow in response to acute b-blocker and vasodilatory treatment in patients with liver cirrhosis. Hepatology 1986;6:1248–51.
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Mohr, HH., Gödderz, W. & Meyer zum Büschenfelde, KH. Die Duplexsonographie der Leber und des Pfortadersystems. Med Klin 93, 669–677 (1998). https://doi.org/10.1007/BF03044879
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DOI: https://doi.org/10.1007/BF03044879