Skip to main content
Log in

Penetrierendes Ulcus duodeni als Komplikation eines Arteria-hepatica-Portkatheters bei hepatisch metastasiertem Sigmakarzinom

Penetrating duodenic ulcer complicating hepatic artery infusion therapy

  • Kasuistik
  • Published:
Medizinische Klinik Aims and scope Submit manuscript

Zusammenfassung

□ Hintergrund

Wir berichten über eine typische Komplikation der arteriellen regionalen Chemotherapie der Leber (HAI) bei einem Patienten mit hepatisch metastasiertem Kolonkarzinom. Ein Jahr nach letzter HAI-Therapie zeigte der Patient Symptome einer akuten oberen gastrointestinalen Blutung. Endoskopisch war ein großes Ulcus duodeni mit Penetration in eine benachbarte Lebermetastase nachweisbar. Der Arteria-hepatica-katheter war im Bulbuslumen am Ulkusgrund sichtbar.

□ Schlußfolgerung

Patienten entwickeln in etwa 35% unter HAI-Therapie Ulcera ventriculi/duodeni. Der hier präsentierte Fall stellt in der Ausprägung allerdings eine seltene Komplikation dar.

Summary

□ Case Report

We report a typical complication of hepatic artery infusion therapy (HAI) in a patient with colon cancer metastatic to the liver. One year after the last HAI-therapy the patient presented with upper gastrointestinal bleeding. Endoscopy showed a large duodenic ulcer penetrating into an adjacent hepatic colon cancer metastasis. The hepatic artery catheter was visible at the ground of the duodenic ulcer.

□ Conclusion

Thirty-five percent of patients under HAI-therapy develop gastric/duodenic ulcers. The severity of the HAI complication presented here, however, is quite uncommon.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Allen-Mersh, T. G.,S. Earlam,C. Fordy, K. Abrams, J. Houghton: Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal liver metastases. Lancet 344 (1994), 1255–1260.

    Article  PubMed  CAS  Google Scholar 

  2. Chang, A. E., P. D. Schneider, P. H. Sugarbaker, C. Simpson, M. Culane, S. Steinberg: A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases. Ann. Surg. 206 (1987), 685–693.

    Article  PubMed  CAS  Google Scholar 

  3. Hohn, D. C., R. J. Stagg, M. A. Friedman, J. F. Hannigan, A. Rayner, R. J. Ignoffo, P. Acord, B. J. Lewis: A randomized trial of continuous intravenous versus hepatic intraarterial floxuridine in patients with colorectal cancer metastatic to the liver. The Northern California Oncology Group trial. J. clin. Oncol. 7 (1989), 1646–1654.

    PubMed  CAS  Google Scholar 

  4. Kemeny, N, J. A. Conti, A. Cohen, P. Carnpana, Y. Huang, W. J. Shi, J. Botet, S. Pulliam, J. R. Bertino: Phase II study of hepatic arterial floxuridine, leucovorin, and dexamethasone for unresectable liver metastases from colorectal carcinoma. J. clin. Oncol. 12 (1994), 2288–2295.

    PubMed  CAS  Google Scholar 

  5. Kemeny, N., J. Daly, B. Reichman, N. Geller, J. Botet, P. Oderman: Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. Ann. intern. Med. 107 (1987), 459–465.

    PubMed  CAS  Google Scholar 

  6. Kemeny, N., K. Seiter, J. A. Conti, A. Lohen, J. R. Bertino, E. R. Sigurdson, J. Botet, D. Chapman, M. S. Madu Mazumdar, A. J. Budd: Hepatic arterial floxuridine and leucovorin for unresectable liver metastases from colorectal carcinoma — new dose schedules and survival update. Cancer (Philad.) 73 (1994), 1134–1142.

    Article  CAS  Google Scholar 

  7. Martin, J. K., M. J. O’Connell, H. S. Wieand, R. J. Fitzgibbons, J. A. Mailliard, J. Rubin, D. M. Nagorney, L. K. Tschetter, J. E. Krook: Intra-arterial floxuridine vs systemic fluorouracil for hepatic metastases of colorectal cancer. Arch. Surg. 125 (1990), 1022–1027.

    PubMed  Google Scholar 

  8. Patt, Y. Z., G. M. Mavligit, V. P. Chuang, S. Wallace, S. Johnston, R. S. Benjamin, M. Valdivieso, E. M. Hersh: Percutaneous hepatic arterial infusion (HAI) of mitomycin C and floxuridine (FUDR): an effective treatment for metastatic colorectal carcinoma in the liver. Cancer (Philad.) 46 (1980), 261–265.

    Article  CAS  Google Scholar 

  9. Rougier, P., A. Laplanche, M. Huguiter, J. M. Hay, J. M. Ollivier, J. Escat, R. Salmon, M. Julien, J. C. Roullet Audy, D. Gallot, J. L. Gouzi, J. L. Pailler, D. Elisa, F. Lacaine, S. Roos, N. Rotman, M. Luboinski, P. Lasser: Hepatic arterial infusion of, floxuridine in patients with liver metastases from colorectal carcinoma: Long term results of a prospective, randomized trial. J. clin. Oncol. 10 (1992), 1112–1118.

    PubMed  CAS  Google Scholar 

  10. Rougier, P, P. Zimmermann, P. Crespon, M. Ducreux, J. Kac, M. Charbit, E. Zrihen, D. Eliass, J. Lumbroso, P. Lasser: Gastroduodenal complications of hepatic-arterial chemotherapy of metastases of colorectal origin. Clin. Biol. 13 (1989), 193–196.

    CAS  Google Scholar 

  11. Safi F, R. Bittner, R. Roscher, K. Schuhmacher, W. Gaus, G. H. Berger: Regional chemotherapy for hepatic metastases of colorectal carcinoma (continuous intraarterial versus continuous intraarterial/intravenous therapy). Cancer (Philad.) 64 (1989), 379–387.

    Article  CAS  Google Scholar 

  12. Sullivan, R. D., J. W. Norcross, E. Watkins: Chemotherapy of metastatic liver cancer by prolonged hepatic-artery infusion. New Engl. J. Med. 270 (1964), 321–327.

    Article  PubMed  CAS  Google Scholar 

  13. Sundqvist, K., L. Hafstrom, P. E. Jonsson, A. Lunderquist, E. Nowak: Upper G-I bleeding following intraarterial chemotherapy infusion. Ann. Chir. Gynaec. 72 (1983), 183–186.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jäger, D., Warzelhan, J., Jäger, E. et al. Penetrierendes Ulcus duodeni als Komplikation eines Arteria-hepatica-Portkatheters bei hepatisch metastasiertem Sigmakarzinom. Med. Klin. 92, 680–682 (1997). https://doi.org/10.1007/BF03044825

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03044825

Schlüsselwörter

Key Words

Navigation