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Selensubstitution bei Sepsispatienten

Eine prospektiv randomisierte Studie

Substitution of selenium in septic patients

A prospective randomized study

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Summary

□Patients and Method: In this study the effect of antioxidative therapy with sodium selenite was investigated in patients with systemic inflammatory response syndrome (S. I. R. S.) and multiple organ failure. 40 patients were included in this prospective randomized study. The patients were observed over a period of 28 days. The letality rate within 28 days was excepted as main criteria. The Apache-II and the MOF-Score of Goris were used as clinical parameters. 20 patients were treated with sodium selenite ver a period of 28 days.

□Result: This antioxidative therapy reduced the letality rate from 40 to 15%.

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Literatur

  1. Böhrer, H., F. Qiu, T. Zimmermann et al.: Role of NF-B in the mortality of sepsis. J. clin. Invest. (in press).

  2. Schreck, R., K. Albermann, P. A. Baeuerle: Nuclear factor B: an oxidative stress responsive transcription factor of eukaryotic cells (a review). Free Radicals Res. Comm. 17 (1992), 221–237.

    Article  CAS  Google Scholar 

  3. Urban, T., C. Jarstrand: Selenium effects on human neutrophilic granulocyte function in vitro. Immunopharmacology 12 (1986), 167–172.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Klinik für Viszeral-, Thorax- und Gefäßchirurgie der TU Dresden, Fetscherstraße 74, D-01307, Dresden

    Thomas Zimmermann & Robert Grützmann

  2. Klinik für Gynäkologie und Geburtshilfe, Germany

    Steffen Albrecht & Steffi Kopprasch

  3. Abteilung für Pathobiochemie der III. Medizinischen Klinik des Universitätsklinikums „Carl Gustav Carus“ der TU Dresden, Germany

    Helmut Hühne

  4. Chirurgische Abteilung, Krankenhaus Meißen, Germany

    Ullrich Vogeslang

Authors
  1. Thomas Zimmermann
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  2. Steffen Albrecht
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  3. Helmut Hühne
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  4. Ullrich Vogeslang
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  5. Robert Grützmann
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  6. Steffi Kopprasch
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Zimmermann, T., Albrecht, S., Hühne, H. et al. Selensubstitution bei Sepsispatienten. Med Klin 92 (Suppl 3), 3–4 (1997). https://doi.org/10.1007/BF03041947

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  • DOI: https://doi.org/10.1007/BF03041947

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