Literatur
Welty-Wolf KE, Carraway MS, Miller DL, Ortel TL, Ezban M, Ghio AJ, Idell S, Piantadosi CA (2001) Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons. Am J Respir Crit Care Med 164: 1988–1996
Voelkel NF, Cool C, Taraceviene SL, G MW, Yeager M, Bull T, Kasper M, Tuder RM (2002) Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension. Crit Care Med 30: S251–256
Hoshikawa Y, Voelkel NF, Gesell TL, Moore MD, Morris KG, Alger LA, Narumiya S, Geraci MW (2001) Prostacyclin receptor-dependent modulation of pulmonary vascular remodeling. Am J Respir Crit Care Med 164: 314–318
Berger RM, Geiger R, Hess J, Bogers AJ, Mooi WJ (2001) Altered arterial expression patterns of inducible and endothelial nitric oxide synthase in pulmonary plexogenic arteriopathy caused by congenital heart disease. Am J Respir Crit Care Med 163: 1493–1499
Giaid A, Yanagisawa M, Langleben D, Michel RP, Levy R, Shennib H, Kimura S, Masaki T, Duguid WP, Stewart DJ (1993) Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 328: 1732–1739
Yuan XJ, Wang J, Juhaszova M, Gaine SP, Rubin LJ (1998) Attenuated K+ channel gene transcription in primary pulmonary hypertension. Lancet 351 (9104): 726–727
Cowan KN, Jones PL, Rabinovitch M (2000) Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease. J Clin Invest 105: 21–34
Zaidi SHE, You XM, Ciura SM, Husain M, Rabinovitch M (2002) Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension. Circulation 105: 516–521
Cowan KN, Heilbut A, Humpl T, Lam C, Ito S, Rabinovitch M (2000) Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat Med 6: 698–702
Newman JH, Wheeler L, Lane KB, Loyd E, Gaddipati R, Phillips JA 3rd, Loyd JE (2001) Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N Engl J Med 345: 319–324
Morse JH, Deng Z, Knowles JA (2001) Genetic aspects of pulmonary arterial hypertension. Ann Med 33: 596–603
Geraci MW, Moore M, Gesell T, Yeager ME, Alger L, Golpon H, Gao B, Loyd JE, Tuder RM, Voelkel NF (2001) Gene expression patterns in the lungs of patients with primary pulmonary hypertension: a gene microarray analysis. Circ Res 88: 555–562
Du L, Sullivan CC, Chu D, Cho AJ, Kido M, Wolf PL, Yuan JX, Deutsch R, Jamieson SW, Thistlethaite PA (2003) Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med 348: 500–509
Rich S (ed) (1998) Executive summary from the World Symposium on Primary pulmonary Hypertension Evian, France, co-sponsered by the World Health Organisation. (http:/www.who.int/cvd/pph/html)
Sun XG, Hansen JE, Oudiz RJ, Wasserman K (2003) Pulmonary function in primary pulmonary hypertension. J Am Coll Cardiol 41: 1028–1035
Ziesche R, Petkov V, Wittmann K, Kopatschka J, Stiebellehner L, Schenk P, Germann P, Röder G, Ullrich R, Block LH (2000) Treatment with epoprostenol reverts nitric oxide non-responsiveness in patients with primary pulmonary hypertension. Heart 83: 406–409
Higenbottam T, Wheeldon D, Wells F, Wallwork J (1984) Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol (prostacyclin). Lancet i (8385): 1046–1047
Hantano S, Strasser T (eds) (1975) Primary pulmonary hypertension. Report on the WHO Meeting. World Health Organisation, Geneva. In: Higenbottam TW (ed) Therapy for patients with pulmonary vascular disease. N Engl J Med 306: 557–564
D’Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Kernis JT, et al (1991) Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 115: 343–349
Fuster V, Steele PM, Edwards WD, Gersh BJ, McGoon MD, Frye RL (1984) Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation 70: 580–587
Jones DK, Higenbottam TW, Wallwork J (1987) Treatment of primary pulmonary hypertension intravenous epoprostenol (prostacyclin). British Heart Journal 57: 270–278
Higenbottam T (1987) The place of prostacyclin in the clinical management of primary pulmonary hypertension. Am Rev Resp Dis 136: 782–785
Jones K, Higenbottam T, Wallwork J (1989) Pulmonary vasodilation with prostacyclin in primary and secondary pulmonary hypertension. Chest 96: 784–789
Rubin LJ, Groves BM, Reeves JT, Frosolono M, Handel F, Cato AE (1982) Prostacyclin-induced acute pulmonary vasodilation in primary pulmonary hypertension. Circulation 66: 334–338
Rubin LJ, Mendoza J, Hood M, McGoon M, Barst R, Williams WB, et al (1990) Treatment of primary pulmonary hypertension with continuous intravenous prostacy-clin (epoprostenol). Results of a randomized trial. Ann Intern Med 112: 485–491
Barst RJ, Rubin LJ, McGoon MD, Caldwell EJ, Long WA, Levy PS (1994) Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin. Ann Intern Med 121: 409–415
Higenbottam T, Butt AY, McMahon A, Westerbeck R, Sharples L (1998) Long term intravenous prostaglandin (epoprostenol or iloprost) for treatment of severe pulmonary hypertension. Heart 80: 151–155
Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, Groves BM, Tapson VF, Bourge RC, Brundage BH, et al (1996) A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N Engl J Med 334: 296–302
McLaughlin VV, Genthner DE, Panella MM, Rich S (1998) Reduction in pulmonary vascular resistance with long-term epoprostenol prostacyclin) therapy in primary pulmonary hypertension. N Engl J Med 338: 273–277
Shapiro SM, Oudiz RJ, Cao T, Romano MA, Beckmann XJ, Georgiou D, Mandayam S, Ginzton LE, Brundage BH (1997) Primary pulmonary hypertension: improved longterm effects and survival with continuous intravenous epoprostenol infusion. J Am Coll Cardiol 30: 343–349
Rubin LJ (1997) Primary pulmonary hypertension. N Engl J Med 336: 111–117
Olschewski H, Walmrath D, Schermuly R, Ghofrani A, Grimminger F, Seeger W (1996) Aerosolized prostacyclin and iloprost in severe pulmonary hypertension. Ann Intern Med 124: 820–824
Wensel R, Opitz CF, Ewert R, Bruch L, Kleber FX (2000) Effects of iloprost inhalation on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension. Circulation 101: 2388–2392
Olschewski H, Ghofrani HA, Schmehl T, Winkler J, Wilkens H, Hoeper MM, Behr J, Kleber FX, Seeger W (2000) Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. Ann Intern Med 132: 435–443
Hoeper MM, Schwarze M, Ehlerding S, Adler Schuermeyer A, Spiekerkoetter E, Niedermeyer J, Hamm M, Fabel H (2000) Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N Engl J Med 342: 1866–1870
Machherndl S, Kneussl M, Baumgartner H, Schneider B, Petkov V, Schenk P, Lang IM (2001) Long-term treatment of pulmonary hypertension with aerosolized iloprost. Eur Respir J 17: 8–13
Olschewski H, Simonneau G, Galie N, Higenbottam T, et al, for the Aerosolized Iloprost Randomized Study Group (2002) Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 347: 322–329
Simmoneau G, Barst RJ, Galiè N, Naeije R, Rich S, Bourge RC, Keogh A, Oudiz R, Frost A, Blackburn SD, Crow JW, Rubin LJ, for the Treprostinil Study Group (2002) Continuous subcutaneous infusion of Treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebocontrolled trial. Am J Respir Crit Care Med 165: 800–804
Galiè N, Humbert M, Vachiery JL, Vizza CD, Kneussl M, Manes A, Sitbon O, Torbicki A, Delcroix M, Naeije R, Hoeper M, Chaouat A, Morand S, Besse B, Simmoneau G for the Arterial Pulmonary Hypertension and Beraprost European Trial (ALPHABET) Study Group (2002) Effect of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomised, double-blind, placebo-controlled trial. J Am Coll Card 39: 1496–1502
Channick RN, Simonneau G, Sitbon O, Robbins I, Frost A, Tapson VF, Badesch DB, Roux S, Raisinio M, Bodin F, et al (2001) Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet 358: 1119–1123
Rubin LJ, Badesch DB, Barst RJ, Galiè N, Black CM, Keogh A, Pulido T, Frost A, Roux S, Leconte I, et al (2002) Bosentan in patients with pulmonary artery hypertension: a randomized, placebo controlled, multicenter study. N Engl J Med 346: 896–903
Palevsky HI, Schloo BL, Pietra GG, Weber KT, Janicki JS, Rubin E, et al (1989) Primary pulmonary hypertension. Vascular structure, morphometry, and responsiveness to vasodilator agents. Circulation 80: 1207–1221
Sitbon O, Humbert M, Jagot JL, Taravella O, Fartoukh M, Parent F, et al (1998) Inhaled nitric oxide as a screening agent for safely identifying responders to oral calciumchannel blockers in primary pulmonary hypertension. Eur Respir J 12: 265–270
Rich S, Kaufmann E, Levy PS (1992) The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med 327: 76–81
Fuster V, Steele PM, Edwards WD, Gersh BJ, McGoon MD, Frye RL (1984) Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation 70: 580–587
Reitz BA, Wallwork JL, Hunt SA, Pennock JL, Billingham ME, Oyer PE, Stinson EB, Shumway NE (1982) Heartlung transplantation: successful therapy for patients with pulmonary vascular disease. N Engl J Med 306: 557–564
Tamm M, Sharples LD, Higenbottam TW, Stewart S, Wallwork J (1997) Bronchiolitis obliterans syndrome in heartlung transplantation — surveillance biopsies. Am J Respir Crit Care Med 155: 1705–1710
Keck BM, Bennett LE, Fiol BS, Daily OP, Novick RJ, Hosenpud JD (1998) Worldwide thoracic organ transplantation: a report from the UNOS/ISHLT International Registry for Thoracic Organ Transplantation. Clin Transplant: 39–52
Meyers BF, Lynch J, Trulock EP, Guthrie TJ, Cooper JD, Patterson GA (1999) Lung transplantation: a decade of experience. Ann Surg 230: 362–370
The American Society for Transplant Physicians (ASTP)/ American Thoracic Society (ATS)/European Respiratory Society (ERS)/International Society for Heart and Lung Transplantation (ISHLT) (1998) International guidelines for the selection of lung transplant candidates. Am J Respir Crit Care Med 158: 335–339
Kerstein D, Levy PS, Hsu DT, Hordof AJ, Gersony WM, Barst RJ (1995) Blade balloon atrial septostomy in patients with severe primary pulmonary hypertension. Circulation 91: 2028–2035
Rich S, Dodin E, McLaughlin VV (1997) Usefulness of atrial septostomy as a treatment for primary pulmonary hypertension and guidelines for its application. Am J Cardiol 80: 369–371
Sandoval J, Gaspar J, Pulido T, Bautista E, Martinez GM, Zeballos M, et al (1998) Graded balloon dilation atrial septostomy in severe primary pulmonary hypertension. A therapeutic alternative for patients nonresponsive to vasodilator treatment. J Am Coll Cardiol 32: 297–304
Petkov V, Mosgoeller W, Ziesche R, Raderer M, Stiebellehner L, Vonbank K, Funk GC, Hamilton G, Novotny C, Burian B, Block LH (2003) Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension. J Clin Invest 111: 1339–1346
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Ziesche, R. Konsensus-Empfehlungen der Arbeitsgruppe Pulmonalarterielle Hypertension der Österreichischen Gesellschaft für Lungenerkrankungen und Tuberkulose. Wien Klin Wochenschr 115, 351–365 (2003). https://doi.org/10.1007/BF03041488
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DOI: https://doi.org/10.1007/BF03041488