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Human brain derived cell culture models of HIV-1 infection

  • Part II Experimental Models of Had
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Abstract

During the clinical course of acquired immune deficiency syndrome, infection of the CNS by human immunodeficiency virus-1 (HIV-1) may ultimately result in the impairment of cognitive, behavioral and motor functions. Viral neuropathogenesis involves inflammatory molecules and neurotoxins produced from infected and immune-activated lymphocytes, microglial cells and astrocytes. Here, we discuss the current understanding of HIV-1 infection of the CNS and various cell culture systems from the developing human brain in order to study the neurobiology of HIV-1 infection, the mechanisms contributing to HIV-1 infection, and disease progression.

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  1. Molecular and Cellular Neuroscience, National Brain Research Centre, Manesar, India

    Pankaj Seth

  2. Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 20892-1296, Bethesda, MD, USA

    Eugene O. Major

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Seth, P., Major, E.O. Human brain derived cell culture models of HIV-1 infection. neurotox res 8, 83–89 (2005). https://doi.org/10.1007/BF03033821

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