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Neurotoxicity of methamphetamine and methylenedioxymethamphetamine

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References

  • Albers, D.S. and P.K., Sonsalla, 1995, Methampheta-mine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents, J Pharmacol Exp Ther275, 1104.

    PubMed  CAS  Google Scholar 

  • Ames, B.N., M.K., Shigenaga and T.M., Hagen, 1993, Oxidants, antioxidants and the degenerative diseases of aging, Proc Natl Acad Sci U S A90, 7915.

    Article  PubMed  CAS  Google Scholar 

  • Ando, K., C.E., Johanson and C.R., Schuster, 1986, Effects of dopaminergic agents on eye tracking before and after repeated methamphetamine, Pharmacol Biochem Behav24, 693.

    Article  PubMed  CAS  Google Scholar 

  • Ando, K., C.E., Johanson, L.S., Seiden and C.R., Schuster, 1985, Sensitivity changes to dopaminergic agents in fine motor control of rhesus monkeys after repeated methamphetamine administration, Pharmacol Biochem Behav22, 737.

    Article  PubMed  CAS  Google Scholar 

  • Angrist, B.M., J.W., Schweitzer, S., Gershon and A.J., Friedhoff, 1970, Mephentermine psychosis: misuse of the Wyamine inhaler, Am J Psychiatry126, 1315.

    PubMed  CAS  Google Scholar 

  • Axt, K.J., D.L., Commins, G., Vosmer and L.S., Seiden, 1990, alpha-Methyl-p-tyrosine pretreatment partially prevents methamphetamine-induced endogenous neurotoxin formation, Brain Res515, 269.

    Article  PubMed  CAS  Google Scholar 

  • Bandy, B. and A.J., Davison, 1990, Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?, Free Radic Biol Med8, 523.

    Article  PubMed  CAS  Google Scholar 

  • Battaglia, G., B.P., Brooks, C., Kulsakdinun and E.B., De Souza, 1988b, Pharmacologic profile of MDMA (3,4-methylene-dioxymethamphetamine) at various brain recognition sites, Eur J Pharmacol149, 159.

    Article  PubMed  CAS  Google Scholar 

  • Battaglia, G., S.Y., Yeh and E.B., De Souza, 1988a, MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons, Pharmacol Biochem Behav29, 269.

    Article  PubMed  CAS  Google Scholar 

  • Battaglia, G., S.Y., Yeh, E., O’Hearn, M.E., Molliver, M.J., Kuhar and E.B., De Souza, 1987, 3,4-Methylenedioxymetham-phetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxet-ine-labeled serotonin uptake sites, J Pharmacol Exp Ther242, 911.

    PubMed  CAS  Google Scholar 

  • Berger, U.V., X.F., Gu and E.C., Azmitia, 1992, The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine, Eur J Pharmacol215, 153.

    Article  PubMed  CAS  Google Scholar 

  • Boveris, A. and B., Chance, 1973, The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen, Biochem J134, 707.

    PubMed  CAS  Google Scholar 

  • Bowyer, J.F., D.L., Davies, L., Schmued, H.W., Broening, G.D., Newport, W., Slikker Jr., and R.R. Holson, 1994, Further studies of the role of hyperthermia in methamphetamine neurotoxicity, J Pharmacol Exp Ther268, 1571.

    PubMed  CAS  Google Scholar 

  • Bowyer, J.F., B., Gough, W., Slikker Jr., G.W. Lipe, G.D. Newport and R.R. Holson, 1993, Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats, Pharmacol Biochem Behav44, 87.

    Article  PubMed  CAS  Google Scholar 

  • Bowyer, J.F., A.W., Tank, G.D., Newport, W., Slikker, Jr., S.F. Ali and R.R. Holson, 1992, The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum, J Pharmacol Exp Ther260, 817.

    PubMed  CAS  Google Scholar 

  • Cadet, J.L., S., Ali and C., Epstein, 1994a, Involvement of oxygen-based radicals in methamphetamine-induced neurotoxicity: evidence from the use of CuZnSOD transgenic mice Ann N Y Acad Sci738, 388.

    PubMed  CAS  Google Scholar 

  • Cadet, J.L., S.F., Ali, R.B., Rothman and C.J., Epstein, 1995a, Neurotoxicity, drugs and abuse and the CuZn-superox-ide dismutase transgenic mice, Mol Neurobiol11, 155.

    Article  PubMed  CAS  Google Scholar 

  • Cadet, J.L., B., Ladenheim, H., Hirata, R.B., Rothman, S., Ali, E., Carlson, C., Epstein and T.H., Moran, 1995b, Superoxide radicals mediate the biochemical effects of methylenedi-oxymethamphetamine (MDMA): evidence from using CuZn-superoxide dismutase transgenic mice, Synapse21, 169.

    Article  PubMed  CAS  Google Scholar 

  • Cadet, J.L., P., Sheng, S., Ali, R., Rothman, E., Carlson and C., Epstein, 1994b, Attenuation of methamphetamine-induced neurotoxicity in copper Jzinc superoxide dismutase transgenic mice, J Neurochem62, 380.

    PubMed  CAS  Google Scholar 

  • Carter, C.J. and C.J., Pycock, 1978, Differential effects of central serotonin manipulation on hyperactive and stereotyped behaviour, Life Sci23, 953.

    Article  PubMed  CAS  Google Scholar 

  • Cavanagh, J.B., 1995, Principles of Neurotoxicology (Marcel Dekker, New York).

    Google Scholar 

  • Che, S., M., Johnson, G.R., Hanson and J.W., Gibb, 1995, Body temperature effect on methylenedioxymethampheta-mine-induced acute decrease in tryptophan hydroxylase activity, Eur J Pharmacol293, 447.

    Article  PubMed  CAS  Google Scholar 

  • Clayton, D.A., J.N., Doda and E.C., Friedberg, 1974, The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria, Proc Natl Acad Sci U S A71, 2777.

    Article  PubMed  CAS  Google Scholar 

  • Colado, M.I. and A.R., Green, 1994, A study of the mechanism of MDMA (‘ecstasy’)-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds, Br J Pharmacol111, 131.

    PubMed  CAS  Google Scholar 

  • Commins, D.L., G., Vosmer, R.M., Virus, W.L., Woolverton, C.R., Schuster and L.S., Seiden, 1987, Biochemical and histological evidence that methylenedioxymethylampheta-mine (MDMA) is toxic to neurons in the rat brain, J Pharmacol Exp Ther241, 338.

    PubMed  CAS  Google Scholar 

  • Cubells, J.F., S., Rayport, G., Rajendran and D., Sulzer, 1994, Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress, J Neurosci14, 2260.

    PubMed  CAS  Google Scholar 

  • Dafters, R.I., 1994, Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedi-oxymethamphetamine (MDMA or “ecstasy”) in rats, Psychopharmacology (Berl)114, 505.

    Article  CAS  Google Scholar 

  • Eisner, B., 1989, Ecstacy: The MDMA story (Ronins, Berkely, CA).

    Google Scholar 

  • Ellinwood, E.H., 1969, Amphetamine psychosis: a multidimensional process, Semini. Psychiarty1, 208.

    Google Scholar 

  • Farfel, G.M., M.S., Kleven, W.L., Woolverton, L.S., Seiden and B.D., Perry, 1992, Effects of repeated injections of cocaine on catecholamine receptor binding sites, dopamine transporter binding sites and behavior in rhesus monkey, Brain Res578, 235.

    Article  PubMed  CAS  Google Scholar 

  • Farfel, G.M. and L.S., Seiden, 1995a, Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX, J Pharmacol Exp Ther272, 860.

    PubMed  CAS  Google Scholar 

  • Farfel, G.M. and L.S., Seiden, 1995b, Role of hypothermia in the mechanism of protection against serotonergic toxicity. II. Experiments with methamphetamine, p-chloro-amphetamine, fenfluramine, dizocilpine and dextromethorphan, J Pharmacol Exp Ther272, 868.

    PubMed  CAS  Google Scholar 

  • Finnegan, K.T., G., Ricaurte, L.S., Seiden and C.R., Schuster, 1982, Altered sensitivity to d-methylamphetamine, apo-morphine and haloperidol in rhesus monkeys depleted of caudate dopamine by repeated administration of d-methylamphetamine, Psychopharmacology77, 43.

    Article  PubMed  CAS  Google Scholar 

  • Fischer, C, G., Hatzidimitriou, J., Wlos, J., Katz and G., Ricaurte, 1995, Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-) 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”), J Neurosci15, 5476.

    PubMed  CAS  Google Scholar 

  • Fischer, J.F. and A.K., Cho, 1979, Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion model., J. Pharmacol & Exp Ther208, 203.

    CAS  Google Scholar 

  • Fischman, M.W. and C.R., Schuster, 1977, Long-term behavioral changes in the rhesus monkey after multiple daily injections of d-methylamphetamine, J Pharmacol Exp Ther201, 593.

    PubMed  CAS  Google Scholar 

  • Floyd, R.A., 1990, Role of oxygen free radicals in carcinogenesis and brain ischemia, Faseb J4, 2587.

    PubMed  CAS  Google Scholar 

  • Floyd, R.A., M.S., West, K.L., Eneff and J.E., Schneider, 1989, Methylene blue plus light mediates 8-hydroxyguanine formation in DNA, Arch Biochem Biophys273, 106.

    Article  PubMed  CAS  Google Scholar 

  • Frey, H.H., 1975, Hyperthermia induced by amphetamine, p-chloramphetamine and fenfluramine in the rat, Pharmacology13, 163.

    Article  CAS  Google Scholar 

  • Globus, M.Y., R., Busto, B., Lin, H., Schnippering and M.D., Ginsberg, 1995, Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation, J Neurochem65, 1250.

    Article  PubMed  CAS  Google Scholar 

  • Gordon, C.J., W.P., Watkinson, J.P., O’Callaghan and D.B., Miller, 1991, Effects of 3,4-methylenedioxymethamphet-amine on autonomic thermoregulatory responses of the rat, Pharmacol Biochem Behav38, 339.

    Article  PubMed  CAS  Google Scholar 

  • Green, A.R., A.J., Cross and G.M., Goodwin, 1995, Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or “Ecstasy”), Psychopharmacology (Berl)119, 247.

    Article  CAS  Google Scholar 

  • Griffith, J., 1966, A study of illicit amphetamine drug traffic in Oklahoma City, Am J Psychiatry123, 560.

    PubMed  CAS  Google Scholar 

  • Grinspoon, L. and J.B., Bakalar, 1986, Can drugs be used to enhance the psychotherapeutic process?, Am J Psy-chother40, 393.

    CAS  Google Scholar 

  • Halliwell, B., 1992, Reactive oxygen species and the central nervous system, J Neurochem59, 1609.

    Article  PubMed  CAS  Google Scholar 

  • Hegler, J., D., Bittner, S., Boiteux and B., Epe, 1993, Quantification of oxidative DNA modifications in mitochondria, Carcinogenesis14, 2309.

    Article  PubMed  CAS  Google Scholar 

  • Heikkila, R.E., H., Orlansky and G., Cohen, 1975, Studies on the distinction between uptake inhibition and release of (3H)dopamine in rat brain tissue slices, Biochem Pharmacol24, 847.

    Article  PubMed  CAS  Google Scholar 

  • Henry, J.A., K.J., Jeffreys and S., Dawling, 1992, Toxicity and deaths from 3,4-methylenedioxymethamphetamine (“ecstasy”) [see comments], Lancet340, 384.

    Article  PubMed  CAS  Google Scholar 

  • Hirata, H., B., Ladenheim, R.B., Rothman, C., Epstein and J.L., Cadet, 1995, Methamphetamine-induced serotonin neurotoxicity is mediated by superoxide radicals, Brain Res677, 345.

    Article  PubMed  CAS  Google Scholar 

  • Hotchkiss, A.J. and J.W., Gibb, 1980, Long-term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain, J Pharmacol Exp Ther214, 257.

    PubMed  CAS  Google Scholar 

  • Insel, T.R., G., Battaglia, J.N., Johannessen, S., Marra and E.B., De Souza, 1989, 3,4-Methylenedioxymethamphetamine (“ecstasy”) selectively destroys brain serotonin terminals in rhesus monkeys, J Pharmacol Exp Ther249, 713.

    PubMed  CAS  Google Scholar 

  • Johanson, C.E., T.G., Aigner, L.S., Seiden and C.R., Schuster, 1979, The effects of methamphetamine on fine motor control in rhesus monkeys, Pharmacol Biochem Behav11, 273.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, M.P., X.M., Huang and D.E., Nichols, 1991, Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue, Pharmacol Biochem Behav40, 915.

    Article  PubMed  CAS  Google Scholar 

  • Kandel, E.R. and J.H., Schwartz, 1985, Principles of Neural Science (Elsevier, New York).

    Google Scholar 

  • Kaur, H. and B., Halliwell, 1996, Measurement of oxidized and methylated DNA bases by HPLC with electrochemical detection, Biochem J318, 21.

    PubMed  CAS  Google Scholar 

  • Kil, H.Y., J., Zhang and C.A., Piantadosi, 1996, Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats, J Cereb Blood Flow Metab16, 100.

    Article  PubMed  CAS  Google Scholar 

  • Kramer, J.C., V.S., Fischman and D.C., Littlefield, 1967, Amphetamine abuse. Pattern and effects of high doses taken intravenously., JAMA201, 305.

    Article  PubMed  CAS  Google Scholar 

  • Levine, M.S., CD., Hull, E., Garcia-Rill, L., Erinoff, N.A., Buchwald and A., Heller, 1980, Long-term decreases in spontaneous firing of caudate neurons induced by amphetamine in cats, Brain Res194, 263.

    Article  PubMed  CAS  Google Scholar 

  • Lew, R., J. Malberg, G.A. Ricaurte and L.S. Seiden, 1997, Evidence for mechanism of action of neurotoxicity of amphetamine related compounds, in: Highly selective neurotoxins. Basic and clinical applications, ed. R.M. Kostrzewa (Humana Press,.

  • Lew, R., K.E., Sabol, C., Chou, G.L., Vosmer, J., Richards and L.S., Seiden, 1996, Methylenedioxymethampheta-mine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part II: Radioligand binding and autoradiography studies, J Pharmacol Exp Ther276, 855.

    PubMed  CAS  Google Scholar 

  • Liang, N.Y. and CO., Rutledge, 1982, Comparison of the release of [3H]dopamine from isolated corpus striatum by amphetamine, fenfluramine and unlabelled dopamine, Biochem Pharmacol31, 983.

    Article  PubMed  CAS  Google Scholar 

  • Linnane, A.W., S., Marzuki, T., Ozawa and M., Tanaka, 1989, Mitochondrial DNA rrtutations as an important contributor to ageing and degenerative diseases, Lancet1, 642.

    Article  PubMed  CAS  Google Scholar 

  • Lorez, H. 1981, Fluorescence histochemistry indicates damage of striatal dopamine nerve terminals in rats after multiple doses of methamphetamine, Life Sci28, 911.

    Article  PubMed  CAS  Google Scholar 

  • Malberg, J.E., K.E., Sabol and L.S., Seiden, 1996, Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat, J Pharmacol Exp Ther278, 258.

    PubMed  CAS  Google Scholar 

  • Malberg, J.E. and L.S., Seiden, 1998, Small changes in ambient temperature cause large changes in 3,4-methylenedi-oxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat, J Neurosci18, 5086.

    PubMed  CAS  Google Scholar 

  • McKenna, D.J., X.M., Guan and A.T., Shulgin, 1991, 3,4-Meth-ylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine, Pharmacol Biochem Behav38, 505.

    Article  PubMed  CAS  Google Scholar 

  • Mecocci, P., U., MacGarvey and M.F., Beal, 1994, Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease, Ann Neurol36, 747.

    Article  PubMed  CAS  Google Scholar 

  • Mecocci, P., U., MacGarvey, A.E., Kaufman, D., Koontz, J.M., Shoffner, D.C., Wallace and M.F., Beal, 1993, Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain, Ann Neurol34, 609.

    Article  PubMed  CAS  Google Scholar 

  • Miller, D.B. and J.P., O’Callaghan, 1994, Environment-, drug-and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse, J Pharmacol Exp Ther270, 752.

    PubMed  CAS  Google Scholar 

  • Miquel, J., 1992, An update on the mitochondrial-DNA mutation hypothesis of cell aging, Mutat Res275, 209.

    PubMed  CAS  Google Scholar 

  • Molliver, M.E., L.A., Mamounas and M.A., Wilson, 1989, Effects of neurotoxic amphetamines on serotonergic neurons: immunocytochemical studies, NIDA Res Monogr94, 270.

    PubMed  CAS  Google Scholar 

  • Nencini, P., W.L., Woolverton and L.S., Seiden, 1988, Enhancement of morphine-induced analgesia after repeated injections of methylenedioxymethamphetamine, Brain Res457, 136.

    Article  PubMed  CAS  Google Scholar 

  • Nichols, D.E., 1986, Differences between the mechanism of action of MDMA, MBDB and the classic hallucinogens. Identification of a new therapeutic class: entactogens, J Psychoactive Drugs18, 305.

    PubMed  CAS  Google Scholar 

  • Nwanze, E. and G., Jonsson, 1981, Amphetamine neurotoxicity on dopamine nerve terminals in the caudate nucleus of mice, Neurosci Lett26, 163.

    Article  PubMed  CAS  Google Scholar 

  • O’Hearn, E., G., Battaglia, E.B., De Souza, M.J., Kuhar and M.E., Molliver, 1988, Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in fore-brain: immunocytochemical evidence for neurotoxicity, J Neurosci8, 2788.

    PubMed  CAS  Google Scholar 

  • Olanow, C.W., 1992, An introduction to the free radical hypothesis in Parkinson’s disease, Ann Neurol32, S2.

    Article  PubMed  CAS  Google Scholar 

  • Parker, E.M. and L.X., Cubeddu, 1986, Effects of d-ampheta-mine and dopamine synthesis inhibitors on dopamine and acetylcholine neurotransmission in the striatum. I. Release in the absence of vesicular transmitter stores, J Pharmacol Exp Ther237, 179.

    PubMed  CAS  Google Scholar 

  • Peroutka, S.J., 1987, Incidence of recreational use of 3,4-meth-ylenedimethoxymethamphetamine (MDMA, “ecstasy”) on an undergraduate campus [letter], N Engl J Med317, 1542.

    PubMed  CAS  Google Scholar 

  • Peroutka, S.J., H., Newman and H., Harris, 1988, Subjective effects of 3,4-methylenedioxymethamphetamine in recreational users, Neuropsychopharmacology1, 273.

    PubMed  CAS  Google Scholar 

  • Preston, E., S., Ma and N., Haas, 1990, Ambient temperature modulation of fenfluramine-induced thermogenesis in the rat, Neuropharmacology29, 277.

    Article  PubMed  CAS  Google Scholar 

  • Preston, K.L. and C.R., Schuster, 1982, A comparison of the central and peripheral effects of atropine on force lever performance, Pharmacol Biochem Behav16, 423.

    Article  PubMed  CAS  Google Scholar 

  • Raiteri, M., F., Cerrito, A.M., Cervoni and G., Levi, 1979, Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine, J Pharmacol Exp Ther208, 195.

    PubMed  CAS  Google Scholar 

  • Randall, T., 1992, Ecstasy-fueled ‘rave’ parties become dances of death for English youths [news] [see comments], Jama268, 1505.

    Article  PubMed  CAS  Google Scholar 

  • Ricaurte, G., G., Bryan, L., Strauss, L., Seiden and C., Schuster, 1985, Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals, Science229, 986.

    Article  PubMed  CAS  Google Scholar 

  • Ricaurte, G.A., L.E., DeLanney, I., Irwin and J.W., Langston, 1988a, Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration, Brain Res446, 165.

    Article  PubMed  CAS  Google Scholar 

  • Ricaurte, G.A., K.T., Finnegan, I., Irwin and J.W., Langston, 1990, Aminergic metabolites in cerebrospinal fluid of humans previously exposed to MDMA; Preliminary observations., Ann N.Y. Acad. Sci.600, 699.

    Article  PubMed  CAS  Google Scholar 

  • Ricaurte, G.A., L.S., Forno, M.A., Wilson, L.E., DeLanney, I., Irwin, M.E., Molliver and J.W., Langston, 1988b, (+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates, Jama260, 51.

    Article  PubMed  CAS  Google Scholar 

  • Ricaurte, G.A., R.W., Guillery, L.S., Seiden, C.R., Schuster and R.Y., Moore, 1982, Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain, Brain Res235, 93.

    Article  PubMed  CAS  Google Scholar 

  • Ricaurte, G.A., A.L., Martello, J.L., Katz and M.B., Martello, 1992, Lasting effects of (+-)-3,4-methylenedioxymetham-phetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations, J Pharmacol Exp Ther261, 616.

    PubMed  CAS  Google Scholar 

  • Ricaurte, G.A. and U.D., McCann, 1992, Neurotoxic amphetamine analogues: effects in monkeys and implications for humans, Ann N Y Acad Sci648, 371.

    Article  PubMed  CAS  Google Scholar 

  • Ricaurte, G.A., C.R., Schuster and L.S., Seiden, 1980, Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: a regional study, Brain Res193, 153.

    Article  PubMed  CAS  Google Scholar 

  • Richards, J.B., K.E., Sabol and L.S., Seiden, 1993, DRL interre-sponse-time distributions: quantification by peak deviation analysis, J Exp Anal Behav60, 361.

    Article  PubMed  CAS  Google Scholar 

  • Richter, C, 1992, Reactive oxygen and DNA damage in mitochondria, Mutat Res275, 249.

    PubMed  CAS  Google Scholar 

  • Richter, C. and G.E., Kass, 1991, Oxidative stress in mitochondria: its relationship to cellular Ca2+ homeostasis, cell death, proliferation and differentiation, Chem Biol Interact77, 1.

    Article  PubMed  CAS  Google Scholar 

  • Rudnick, G. and S.C., Wall, 1992, The molecular mechanism of “ecstasy” [3,4-methylenedioxymethamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release, Proc Natl Acad Sci U S A89, 1817.

    Article  PubMed  CAS  Google Scholar 

  • Ryan, L.J., J.C., Under, M.E., Martone and P.M., Groves, 1990 Histological and ultrastructural evidence that D-amphetamine causes degeneration in neostriatum and frontal cortex of rats, Brain Res518, 67.

    Article  PubMed  CAS  Google Scholar 

  • Sabol, K.E., R., Lew, J.B., Richards, G.L., Vosmer and L.S., Seiden, 1996, Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part I: Synaptosomal uptake and tissue concentrations, J Pharmacol Exp Ther276, 846.

    PubMed  CAS  Google Scholar 

  • Scanzello, C.R., G., Hatzidimitriou, A.L., Martello, J.L., Katz and G.A., Ricaurte, 1993, Serotonergic recovery after (+/-)3,4-(methylenedioxy) methamphetamine injury: observations in rats, J Pharmacol Exp Ther264, 1484.

    PubMed  CAS  Google Scholar 

  • Schapira, A.H., 1995, Oxidative stress in Parkinson’s disease, Neuropathol Appl Neurobiol21, 3.

    Article  PubMed  CAS  Google Scholar 

  • Scheffel, U. and G.A., Ricaurte, 1990, Paroxetine as an in vivo indicator of 3,4-methylenedioxymethamphetamine neurotoxicity: a presynaptic serotonergic positron emission tomography ligand?, Brain Res527, 89.

    Article  PubMed  CAS  Google Scholar 

  • Scheffel, U., Z., Szabo, W.B., Mathews, P.A., Finley, R.F., Dan-nals, H.T., Ravert, K., Szabo, J., Yuan and G.A., Ricaurte, 1998, In vivo detection of short- and long-term MDMA neurotoxicity-a positron emission tomography study in the living baboon brain, Synapse29, 183.

    Article  PubMed  CAS  Google Scholar 

  • Schmidt, C.J., 1987a, Acute administration of methylenedi-oxymethamphetamine: comparison with the neurochemical effects of its N-desmethyl and N-ethyl analogs, Eur J Pharmacol136, 81.

    Article  PubMed  CAS  Google Scholar 

  • Schmidt, C.J., 1987b, Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine, J Pharmacol Exp Ther240, 1.

    PubMed  CAS  Google Scholar 

  • Schmidt, C.J., C.K., Black, G.M., Abbate and V.L., Taylor, 1990, Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors, Brain Res 529, 85. Schmidt, C.J., L. Wu and W. Lovenberg, 1986, Methylenedioxymethamphetamine: a potentially neurotoxic amphetamine analogue, Eur J Pharmacol124, 175.

    Article  Google Scholar 

  • Schuster, C.R. and T., Thompson, 1969, Self administration of and behavioral dependence on drugs, Annu Rev Pharmacol9, 483.

    Article  PubMed  CAS  Google Scholar 

  • Seiden, L.S., M.W., Fischman and C.R., Schuster, 1976, Long-term methamphetamine induced changes in brain catecholamines in tolerant rhesus monkeys, Drug Alcohol Depend1, 215.

    Article  PubMed  CAS  Google Scholar 

  • Seiden, L.S., M.W., Fischman and C.R., Schuster, 1977, Changes in brain catecholamines induced by long-term methamphetamine administration in rhesus monkeys. pp. 179–85, In: Ellinwood EH Jr., Kilbey MM, ed. Cocaine and other stimulants. New York, Plenum Press.

    Google Scholar 

  • Seiden L.S and G., Ricaurte, 1987, Neurotoxicity of methamphetamine and related drugs, in: Psychopharmacology: The third generation of progress, ed. H.Y. Meltzer (Raven Press, New York).

    Google Scholar 

  • Seiden, L.S., K.E., Sabol and R.S., Dyer, 1995, Neurotoxicity of methamphetamine-related drugs and cocaine, in: Handbook of Neurotoxicology, ed. L.W. Chang (Marcel Dekker, New York) p. 825.

    Google Scholar 

  • Seiden, L.S., K.E., Sabol and G.A., Ricaurte, 1993, Amphetamine: effects on catecholamine systems and behavior, Annu Rev Pharmacol Toxicol33, 639.

    Article  PubMed  CAS  Google Scholar 

  • Sies, H., 1986, Oxidative Stress: introductory remarks, in: Oxidative Stress, ed. H. Sies (Academic, Orlando, Florida) p. 1.

    Google Scholar 

  • Sonsalla, P.K., W.J., Nicklas and R.E., Heikkila, 1989, Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity, Science243, 398.

    Article  PubMed  CAS  Google Scholar 

  • Steele, T.D., U.D., McCann and G.A., Ricaurte, 1994, 3,4-Meth-ylenedioxymethamphetamine (MDMA, “Ecstasy”): pharmacology and toxicology in animals and humans, Addiction89, 539.

    Article  PubMed  CAS  Google Scholar 

  • Steranka, L.R. and E., Sanders-Bush, 1980, Long-term effects of continuous exposure to amphetamine on brain dopamine concentration and synaptosomal uptake in mice, Eur J Pharmacol65, 439.

    Article  PubMed  CAS  Google Scholar 

  • Stone, D.M., G.R., Hanson and J.W., Gibb, 1987, Differences in the central serotonergic effects of methylenedioxymeth-amphetamine (MDMA) in mice and rats, Neuropharmacology26, 1657.

    Article  PubMed  CAS  Google Scholar 

  • Stone, D.M., M., Johnson, G.R., Hanson and J.W., Gibb, 1988, Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphet-amine, J Pharmacol Exp Ther247, 79.

    PubMed  CAS  Google Scholar 

  • Wagner, G.C., G.A., Ricaurte, C.E., Johanson, C.R., Schuster and L.S., Seiden, 1980a, Amphetamine induces depletion of dopamine and loss of dopamine uptake sites in caudate, Neurology30, 547.

    PubMed  CAS  Google Scholar 

  • Wagner, G.C., G.A., Ricaurte, L.S., Seiden, C.R., Schuster, R.J., Miller and J., Westley, 1980b, Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine, Brain Res181, 151.

    Article  PubMed  CAS  Google Scholar 

  • Wagner, G.C., L.S., Seiden and C.R., Schuster, 1979, Methamphetamine-induced changes in brain catecholamines in rats and guinea pigs, Drug Alcohol Depend4, 435.

    Article  PubMed  CAS  Google Scholar 

  • Walsh, S.L. and G.C. Wagner, 1990, The effect of methamphetamine-induced neurotoxicity on motor performance in the rat., Neurosci. Abs 16, 56.8.

    Google Scholar 

  • Wichems, C.H., C.K., Hollingsworth and B.A., Bennett, 1995, Release of serotonin induced by 3,4-methylenedi-oxymethamphetamine (MDMA) and other substituted amphetamines in cultured fetal raphe neurons: further evidence for calcium-independent mechanisms of release, Brain Res695, 10.

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson, L.O., S.B., Auerbach and B.L., Jacobs, 1991, Extracellular serotonin levels change with behavioral state but not with pyrogen-induced hyperthermia, J Neurosci11, 2732.

    PubMed  CAS  Google Scholar 

  • Woolverton, W.L., G.A., Ricaurte, L.S., Forno and L.S., Seiden, 1989, Long-term effects of chronic methamphetamine administration in rhesus monkeys, Brain Res486, 73.

    Article  PubMed  CAS  Google Scholar 

  • Yehuda, S. and R.J., Wurtman, 1972, The effects of D-amphet-amine and related drugs on colonic temperatures of rats kept at various ambient temperatures, Life Sci [I]11, 851.

    Article  CAS  Google Scholar 

  • Zenick, H. and M., Goldsmith, 1981, Drug discrimination learning in lead-exposed rats, Science212, 569.

    Article  PubMed  CAS  Google Scholar 

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Seiden, L.S., Lew, R. & Malberg, J.E. Neurotoxicity of methamphetamine and methylenedioxymethamphetamine. neurotox res 3, 101–116 (2001). https://doi.org/10.1007/BF03033233

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