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HLA-DRB 1 alleles and the susceptibility of Iranian patients with breast cancer

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Pathology Oncology Research

Abstract

Breast cancer is considered a major malignancy among women worldwide. The contribution of genetic elements to the onset of familial breast cancer has already been established. The current study investigate the alfele frequency of HLA-DRB 1 in 36 primary operable female breast cancer patients from southern Iran by polymerase chain reaction using sequence specific primers (PCR-SSP). Results were compared with those of 36 female control subjects. Statistical analysis was performed and P values were determined for each character. Our results indicated that the frequency of HLA-DRB 1*12 allele is significantly higher in the patient group (p<0.03) compared to the control group. In addition, HLA-DRB1*11 appeared to be as the most frequent allele in the control group (29.2%) and had approximately the same distribution among the patient group (22.5%).

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Authors and Affiliations

  1. Department of Immunology, Medical School, Shiraz University of Medical Sciences, PO BOX: 71345-1798, Shiraz, Iran

    A. Ghaderi, B. Gharesi-Fard, Sh. Farjadian & A. Amirzargar

  2. Department of Surgery, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

    A. Talei

  3. Department of Pathology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

    M. Vasei

Authors
  1. A. Ghaderi
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  2. A. Talei
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  3. B. Gharesi-Fard
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  4. Sh. Farjadian
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  5. A. Amirzargar
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  6. M. Vasei
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Correspondence to A. Ghaderi.

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Ghaderi, A., Talei, A., Gharesi-Fard, B. et al. HLA-DRB 1 alleles and the susceptibility of Iranian patients with breast cancer. Pathol. Oncol. Res. 7, 39–41 (2001). https://doi.org/10.1007/BF03032603

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  • DOI: https://doi.org/10.1007/BF03032603

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