Abstract
Leiomyosarcomas of the breast are rare tumors. Less than 15 such cases have been reported in the literature so far. In this paper authors describe a case of leiomyosarcoma of a female breast presenting as a firm lobulated mass, mimicking a phylloid tumor radiographically. By fine needle aspiration biopsy, on the smears discohesive malignant looking cells were conclusive to a poorly differentiated invasive ductal carcinoma of the breast. The mastectomy specimen contained a lobulated mass, microscopically showing a partly epithelioid spindle cell tumor, immunoreactive for vimentin, desmin, smooth muscle actin antibodies, and negative for epithelial markers, hormone and growth factor receptors. Axillary lymph nodes were free of tumor. A primary leiomyosarcoma of the breast was diagnosed.
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References
Blanchard DK, Budde JM, Hatch GF: 3rd Tumors of the small intestine. World J Surg 24:421–429, 2000.
Burke AP, Virmani R: Sarcomas of the Great Vessels. A Clinicopathologic study. Cancer, 71:1761–1773, 1993.
Burke AP, Virmani R: Tumors of the heart and great vessels, AFIP, 1996.
Falconieri G, Delia Libera D, Zanconati F, Bittesini L: Leiomyosarcoma of the Female Breast. Am J Surg Pathol 108:19–25, 1997.
Glock Y, Laghzaoui A, Wang J: Fissured leiomyosarcoma of the descending thoracic aorta. A propos of a case and review of the literature. Arch Mal Coeur 90:1317–1320, 1997.
Palacios G: Leiomyosarcoma of the Female Breast. Am J Surg Pathol 109:650–651, 1998.
Majeski J, Crawford ES, Majeski EI: Primary aortic intimai sarcoma of the endothelial cell type with long term survival. J Vasc Surg 27:555–558, 1998.
Mentzel T, Calonje E, Fletcher CDM: Leiomyosarcoma with prominent osteoclast-like giant cells Am J Surg Pathol 18:258–265, 1994.
Miracco C, Laurini L, Santopietro R: Intimai type primary sarcoma of the aorta. Report of a case with evidence of rhabdomyosarcomatous differentiation Virchows Arch 435:62–66, 1999.
Patel KR, Niazi TBM, Anthony P: Griffiths.Massive osteolytic bone metastases from a primary aortic sarcoma: a case report. Hum Pathol 28:1306–1310, 1997.
Pautier P, Genestie C, Rey A: Analysis of clinicopathologic prognostic factors for 157 uterine sarcomas and evaluation of a grading score validated for soft tissue sarcoma. Cancer 88:1425–1431, 2000.
Rochais JP, Icard P, Coffin O: Intimal sarcoma of the thoracic aorta: a case report. Eur J Vasc Endovasc Surg 18:181–182, 1999.
Roncaroli F, Eusebi V: Rhabdomyoblastic differentiation in a leiomyosarcoma of the retroperitoneum Hum Pathol 27:310–313, 1996.
Shimoda H, Oka K, Otani S: Vascular leiomyosarcoma arising from the inferior vena cava diagnosed by intraluminal biopsy. Virchows Arch 433:97–100, 1998.
Soh LT, Chew SH, Ang L: Uterine leiomyosarcoma-a Singapore experience. Aust NZJ Obstet Gynecol 39:246–248 1999.
Ugras S, Dilek ON, Karaayvaz M, et al: Primary Leiomyosarcoma of the Breast. Surg Today 27:1082–1085, 1997.
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Székely, E., Madaras, L., Kulka, J. et al. Leiomyosarcoma of the female breast. Pathol. Oncol. Res. 7, 151–153 (2001). https://doi.org/10.1007/BF03032583
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DOI: https://doi.org/10.1007/BF03032583