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Cystic thymoma

  • Case Report
  • Published:
Pathology & Oncology Research

Abstract

Thymic cysts are rare lesions located along the anatomical course of the third pharyngeal pouch. While most of the cases represent congenital cysts, they may also be related to neoplasms. We report a case of a micronodular thymoma with lymphoid stroma, which was completely built of small cysts, discuss the pathologic features of this tumor type and review the etiology and other aspects of thymic cysts.

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References

  1. Bradford ML, Mahon HW, Grow JB: Mediastinal cysts and tumors. Surg Gynecol Obstet 85: 467–491, 1947

    CAS  PubMed  Google Scholar 

  2. Dubois P: Du diagnostic de la syphilis consideree comme une des causes possibles de la mort du foetus. Gaz Med de Paris 21:392–395, 1850

    Google Scholar 

  3. Guba AM jr, Adam AE, Jaques DA, et al: Cervical presentation of thymic cysts. Am J Surg 136:430–436, 1978

    Article  PubMed  Google Scholar 

  4. Hyde TL, Sellers ED, Owen M: Thymic cyst of the neck: report of a case. Tex State J Med 39:539–540, 1944

    Google Scholar 

  5. Indeglia RA, Shea MA, Grage TB: Congenital cysts of the thymus gland. Arch Surg 94:149–152, 1967

    PubMed  CAS  Google Scholar 

  6. Inoue M, Starostik P, Zettl A, et al: Correlating genetic aberrations with World Health Organization-defined histology and stage across the spectrum of thymomas. Cancer Res 63:3708–3715, 2003.

    PubMed  CAS  Google Scholar 

  7. Krech WG, Storey CF, Umiker WC: Thymic cysts: a review of the literature and report of two cases. J Thorac Surg 27: 477–493, 1954

    PubMed  CAS  Google Scholar 

  8. Leong AS, Brown JH: Malignant transformation in a thymic cyst. Am J Surg Pathol 8:471–475, 1984

    Article  PubMed  CAS  Google Scholar 

  9. Marx A, Stroebel P.Marino M, et al: Micronodular thymoma with lymphoid stroma. In: Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. (Eds: WD Travis, E Brambilla HK Müller-Hermelink, CC Harris) World Health Organization of Tumors. IARC Press, Lyon 2004, pp. 167–168

    Google Scholar 

  10. Moran CA, Suster S: Thymoma with prominent cystic and hemorrhagic changes and areas of necrosis and infarction: a clinicopathologic study of 25 cases. Am J Surg Pathol 25:1086–1090, 2001

    Article  PubMed  CAS  Google Scholar 

  11. Murray JA, Parker AC: Mediastinal Hodgkin’s disease and thymic cysts. Acta Haematol (Basel) 71:282–284, 1984

    Article  CAS  Google Scholar 

  12. Penzel R, Hoegel J, Schmitz W, et al: Clusters of chromosomal imbalances in thymic epithelial tumours are associated with the WHO classification and the staging system according to Masaoka. Int J Cancer 105:494–498, 2003

    Article  PubMed  CAS  Google Scholar 

  13. Pollosson A, Piery M: Un cas d’epithelioma primitif du Thymus. Provinc Med 16:1–4, 1901

    Google Scholar 

  14. Rippert H: Die Entwicklungsstörung der Thymusdrüse bei kongenitaler Lues. Frankfurt Z Pathol 11:209–218, 1912

    Google Scholar 

  15. Rosai J, Levine GD: Tumors of the thymus. In: Atlas of Tumor Pathology, 2nd series, fasc 13. Armed Forces Institute of Pathology, Washington DC, 1976, pp 48–49, 207–211.

    Google Scholar 

  16. Smart J: A case of large thymic cyst successfully removed from the anterior mediastinum. Br J Tuberc 41: 84–88, 1947

    Article  CAS  Google Scholar 

  17. Suster S, Moran CA: Primary thymic epithelial neoplasms showing combined features of thymoma and thymic carcinoma. A clinicopathologic study of 22 cases. Am J Surg Pathol 20:1469–1480, 1996

    Article  PubMed  CAS  Google Scholar 

  18. Suster S, Moran CA: Micronodular thymoma with lymphoid B-cell hyperplasia: clinicopathologic and immunohistochemical study of eighteen cases of a distinctive morphologic variant of thymic epithelial neoplasm. Am J Surg Pathol 23:955–962, 1999

    Article  PubMed  CAS  Google Scholar 

  19. Suster S, Rosai J: Multilocular thymic cyst: an acquired reactive process. Study of 18 cases. Am J Surg Pathol 15: 388–398, 1991

    PubMed  CAS  Google Scholar 

  20. Suster S, Rosai J: Cystic thymomas. A clinicopathologic study of ten cases. Cancer 69:92–97, 1992

    Article  PubMed  CAS  Google Scholar 

  21. Tateyama H, Saito Y, Fujii Y, et al: The spectrum of micronodular thymic epithelial tumours with lymphoid B-cell hyperplasia. Histopathology 38: 519–527, 2001

    Article  PubMed  CAS  Google Scholar 

  22. Thomas De Montpreville V, Zemoura L, Dulmet E: Thymoma with epithelial micronodules and lymphoid hyperplasia: six cases of a rare and equivocal subtype. Ann Pathol 22:177–182, 2002

    Google Scholar 

  23. Wychulis AR, Payne WS, Clagett OT, Woolner LB: Surgical treatment of mediastinal tumors —a 40 year experience. J Thorac Cardiovasc Surg 62: 379–392, 1971

    PubMed  CAS  Google Scholar 

  24. Zettl A, Strobel P, Wagner K, et al: Recurrent genetic aberrations in thymoma and carcinoma. Am J Pathol 157:257–266, 2000

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of General Pathology, University Hospital, INF 220/221, 69120, Heidelberg, Germany

    Ralf J. Rieker, Sebastian Aulmann, Philipp A. Schnabel, Herwart F. Otto, Gunhild Mechtersheimer, Peter Schirmacher & Hendrik Bläker

  2. Department of Cardiac Surgery, University Hospital, Heidelberg, Germany

    Falk-Udo Sack

Authors
  1. Ralf J. Rieker
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  2. Sebastian Aulmann
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  3. Philipp A. Schnabel
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  4. Falk-Udo Sack
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  5. Herwart F. Otto
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  6. Gunhild Mechtersheimer
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  7. Peter Schirmacher
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  8. Hendrik Bläker
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Correspondence to Ralf J. Rieker.

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Rieker, R.J., Aulmann, S., Schnabel, P.A. et al. Cystic thymoma. Pathol. Oncol. Res. 11, 57–60 (2005). https://doi.org/10.1007/BF03032408

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  • DOI: https://doi.org/10.1007/BF03032408

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