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Central motor conduction after magnetic stimulation in diabetes

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Abstract

Central motor conduction times (CMCTs), obtained by means of magnetic stimulation of the motor cortex and spinal roots, were studied in 138 patients affected by diabetes mellitus but with no signs or symptoms of central nervous system (CNS) involvement. CMCTs were significantly increased in diabetic patients (p < 0.001,t-test) with respect to normal controls, with values exceeding upper confidence limits (mean ± 2.5 SD of controls) in about 30% of patients. There was no correlation between CMCT delay and type of diabetes (insulin-dependent or non-insulin-dependent), patient age disease duration, degree of metabolic control compensation, presence or absence of retinopathy or nephropathy, and presence or absence of peripheral or autonomic neuropathy. CNS involvement in diabetes mellitus is discussed. Particular emphasis is given to the sensitivity and reliability of CMCTs obtained by means of magnetic stimulation as a tool in the early diagnosis of CNS functional alterations in diabetes mellitus.

Sommario

Il tempo di conduzione motorio centrale (CMCT), ottenuto per stimolazione magnetica (MS) della corteccia motoria e delle radici spinali (C7), è stato studiato in 138 pazienti affetti da diabete mellito (DM), senza segni e/o sintomi di coinvolgimento del sistema nervoso centrale (CNS).

Il CMCT è risultato significativamente allungato nei pazienti diabetici (p<0.001, t-test) rispetto ai valori normativi dei controlli ed il valore del CMCT eccedeva il limite superiore di confidenza (mean ±2.5 SD of controls) nel 30 % circa dei pazienti.

Nessuna correlazione è stata riscontrata tra rallentamento del CMCT e tipo di DM (insulino-dipendente e non insulino-dipendente), età dei pazienti, durata di malattia, grado di controllo metabolico, presenza o meno di retinopatia e di nefropatia, presenza o meno di neuropatia periferica e/o autonomica.

Viene discusso il coinvolgimento del CNS nel DM e vierte sottolineata la sensibilità, e l’attendibilità dello studio del CMCT da MS nella diagnosi precoce delle alterazioni funzionali del CNS nel DM.

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References

  1. Barker AT, Jalinous R, Freeston IL (1985) Noninvasive magnetic stimulation of the motor cortex. Lancet ii: 1106–1107

    Article  Google Scholar 

  2. Berardelli A (1991) Electrical and magnetic spinal and cortical stimulation in man. Curr Opin Neurol Neurosurg 4:770–776

    PubMed  CAS  Google Scholar 

  3. Hess CW, Mills KR, Murray NMF (1987) Responses in small hand muscles from magnetic stimulation of the human brain. J Physiol 388:397–419

    PubMed  CAS  Google Scholar 

  4. Murray NMF (1991) Magnetic stimulation of cortex: Clinical applications. J Clin Neurophysiol 8:66–76

    Article  PubMed  CAS  Google Scholar 

  5. Comi G, Martinelli V, Galardi G, Locatelli T, Maderna L (1992) Evidenze neurofisiologiche delle alterazioni del sistema nervoso centrale nella malattia diabetica. In: Fedele D, Boulton AMJ (eds) La neuropatia diabetica. CIC Edizioni Internazionali, Rome, pp 309–320

    Google Scholar 

  6. Abbruzzese G, Schenone A, Scramuzza G, Caponnetto C, Gasparetto B, Adezati L, Abbruzzese M, Viviani GL (1993) Impairment of central motor conduction in diabetic patients. Electroencephalogr Clin Neurophysiol 89:335–340

    Article  PubMed  CAS  Google Scholar 

  7. Bax G, Lelli S, Grandis U, Cospite AM, Paolo N, Fedele D (1995) Early involvement of central nervous system in type I diabetic patients. Diabetes Care 18:559–562

    Article  PubMed  CAS  Google Scholar 

  8. Maetzu C, Villoslada C, Cruz Martinez A (1995) Somatosensory evoked potentials and central motor pathways conduction after magnetic stimulation of the brain in diabetes. Electromyogr Clin Neurophysiol 35:443–448

    PubMed  CAS  Google Scholar 

  9. D’Annunzio G, Moglia A, Zandrini C, Bollani E, Vitali L, Pessino P, Scaramuzza A, Lanzi G, Lorini R (1995) Central motor conduction time in children and adolescents with insulin-dependent diabetes mellitus (IDDM). Diabetes Res Clin Pract 28:57–62

    Article  PubMed  CAS  Google Scholar 

  10. Dyck PJ, Karnes LJ, Daube J, O’Brien P, Service J (1985) Clinical and neuropathological criteria for the diagnosis and staging of diabetic polyneuropathy. Brain 108:861–880

    Article  PubMed  Google Scholar 

  11. Dyck PJ (1988) Detection, characterization and staging of polyneuropathy assessed in diabetics. Muscle Nerve 11:21–32

    Article  PubMed  CAS  Google Scholar 

  12. Robinson IR, Janton P, McLean IC (1988) Central motor conduction times using transcranial stimulation and F-wave latencies. Muscle Nerve 11:174–180

    Article  PubMed  CAS  Google Scholar 

  13. Vinik AI, Holland MT, Le Beau JM, Liuzzi FJ, Stansberry KB, Cohen LB (1992) Diabetic neuropathies. Diabetes Care 15:1926–1975

    Article  PubMed  CAS  Google Scholar 

  14. Carsten RE, Whalen LR, Ishii DN (1989) Impairment of spinal cord conduction velocity in diabetic rats. Diabetes 38:730–736

    Article  PubMed  CAS  Google Scholar 

  15. Medori R, Autilio-Gambetti L, Monaco S, Gambetti P (1985) Experimental diabetic neuropathy: Impairment of slow transport with changes in axon cross-sectional area. Proc Natl Acad Sci USA 82:7716–7720

    Article  PubMed  CAS  Google Scholar 

  16. McCall A (1992) The impact of diabetes on the CNS. Diabetes 41:557–706

    Article  PubMed  CAS  Google Scholar 

  17. Cracco J, Castells S, Mark E (1984) Spinal somatosensory evoked potentials in juvenile diabetes. Ann Neurol 15: 55–58

    Article  PubMed  CAS  Google Scholar 

  18. Cruz Martinez A (1986) Spinal evoked potentials and single fibre EMG in diabetic neuropathy. Electromyogr Clin Neurophysiol 26: 499–511

    Google Scholar 

  19. Gupta PR, Dorfman LJ (1981) Spinal somatosensory conduction in diabetes. Neurology 31:841–845

    PubMed  CAS  Google Scholar 

  20. Nakamura Y, Takahashi M, Kitaguchi M, Kaido M, Imaoka H, Kono N et al (1989) Clinical utility of somatosensory evoked potentials in diabetes mellitus. Diabetes Res Clin Pract 7:17–23

    Article  PubMed  CAS  Google Scholar 

  21. Van Gerven JMA, Arts R, Lemkes HHPJ (1986) Somatosensory evoked potentials (SSEPs) and electroneurography of sensory nerves in diabetic polyneuropathy (DN). Transplant Proc 18:1592

    Google Scholar 

  22. Comi G, Martini A (1987) Central nervous involvement in diabetic patients. In: Andreani D, Crepaldi G, Di Mario U, Pozza G (eds) Diabetic complications: Early diagnosis and treatment. Wiley, Chichester, pp 145–154

    Google Scholar 

  23. Pozzessere G, Rizzo PA, Valle E, Mollica MA, Meccia A, Morano S et al (1988) Early detection of neurological involvement in IDDM and NIDDM. Multimodal evoked potentials versus metabolic control. Diabetes Care 11:473–480

    Article  PubMed  CAS  Google Scholar 

  24. Fierro B, Meli F, Brighina F, Cardella F, Aloisio A, Olivieri M, Buffa D (1996) Somatosensory and visual evoked potentials study in young insulin-dependent diabetic patients. Electromyogr Clin Neurophysiol 36:481–486

    PubMed  CAS  Google Scholar 

  25. Ziegler D, Muhlen H, Dannehl K, Arnold Gries F (1993) Tibial nerve somatosensory evoked potentials at various stages of peripheral neuropathy in insulin-dependent diabetic patients. J Neurol Neurosurg Psychiatry 56:58–64

    Article  PubMed  CAS  Google Scholar 

  26. Algan M, Ziegler O, Gehin P, Got I, Raspiller A, Weber M et al (1989) Visual evoked potentials in diabetic patients. Diabetes Care 12:227–229

    Article  PubMed  CAS  Google Scholar 

  27. Donald MW, Williams Erdahl DL, Surridge DHC, Monga TN, Lawson JS, Bird CE et al (1984) Functional correlates of reduced central conduction velocity in diabetic subjects. Diabetes 33:627–633

    Article  PubMed  CAS  Google Scholar 

  28. Maertens De Noordhout A, Pepin JL, Gerard P, Delwaide PJ (1992) Facilitation of responses to motor cortex stimulation: Effects of isometric voluntary contraction. Ann Neurol 32 (3):365–370

    Article  Google Scholar 

  29. Eisen A, Odusote K (1979) Amplitude of the F wave: A potential means of documenting spasticity. Neurology 29:1306–1309

    PubMed  CAS  Google Scholar 

  30. Arrigo A, Alfonsi E, Malaguti S, Moglia A, Solerte SB, Schifino N, Severgnini S, Ferrari E (1995) Alterazione delle vie motorie centrali nel diabète: Studio clinico ed elettrofisiologico. In: Moglia A, Marchese D (eds) Atti del Congresso Nazionale Società Italiana di Neurofisiologia Clinica, Centro Stampa Rozzano, Rozzano, p 181 (abstr)

    Google Scholar 

  31. Andersen H, Stalberg E, Falck B (1997) F-wave latency, the most sensitive nerve conduction parameters in patients with diabetes mellitus. Muscle Nerve 20:1296–1302

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Neurophysiology Service, Neurological Institute “C. Mondino”, University of Pavia, Italy Via Palestro 3, I-27100, Pavia, Italy

    A. Moglia, A. Arrigo, E. Alfonsi, A. Bodini & A. Lozza

  2. Division A of Neurology, Neurological Institute “C. Mondino”, University of Pavia, Italy

    M. Maurelli

  3. Diabetes Centre, Section of Hygiene, Department of Preventive Occupational and Community Medicine, University of Pavia, Italy

    M. T. Tenconi

  4. Department of Internal Medicine, Section of Gerontology and Geriatrcs, “S.ta Margherita” Hospital, University of Pavia, Italy

    S. B. Solerte & E. Ferrari

Authors
  1. A. Moglia
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  2. A. Arrigo
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  3. M. Maurelli
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  4. E. Alfonsi
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  5. A. Bodini
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  6. A. Lozza
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  7. M. T. Tenconi
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  8. S. B. Solerte
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  9. E. Ferrari
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Moglia, A., Arrigo, A., Maurelli, M. et al. Central motor conduction after magnetic stimulation in diabetes. Ital J Neuro Sci 19, 10–14 (1998). https://doi.org/10.1007/BF03028805

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  • DOI: https://doi.org/10.1007/BF03028805

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