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Potential biochemical markers for infantile autism

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Neurochemical Pathology

Abstract

Biochemical markers are crucial to the development of early diagnosis of infantile autism. The blood concentrations of neuroanalytes epinephrine, norepinephrine, dopamine, and serotonin were elevated in autistic subjects (n = 13) as compared to normal controls (n = 10). Autistic subjects had peptide patterns (peaks I-V, Sephadex G-25) that were different from those of normal controls. Methionine-enkephalin has been tentatively identified from fraction I of autistic subjects by HPLC as one of a large number of peptides that appears to be elevated. The HPLC chromatographic patterns of fraction V from all autistic subjects show a peak with retention time of 7.6 min. The HPLC of control urine fraction V revealed no comparable peaks.

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Authors and Affiliations

  1. Division of Clinical Chemistry, Department of Pathology, The Ohio State University, USA

    Porn P. Israngkun, Howard A. I. Newman & Suman T. Patel

  2. Department of Surgery, The Ohio State University, 43210, Columbus, OH

    Valentine A. Duruibe & Hussein Abou-Issa

Authors
  1. Porn P. Israngkun
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  2. Howard A. I. Newman
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  3. Suman T. Patel
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  4. Valentine A. Duruibe
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  5. Hussein Abou-Issa
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Israngkun, P.P., Newman, H.A.I., Patel, S.T. et al. Potential biochemical markers for infantile autism. Neurochemical Pathology 5, 51–70 (1986). https://doi.org/10.1007/BF03028036

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  • DOI: https://doi.org/10.1007/BF03028036

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