Abstract
Purpose
Beta blockers are thought to exert beneficial effects on the ischémic heart. The authors examined the effects of landiolol (ONO 1101), a highly selective βl antagonist, propranolol, a nonspecific β blocker, and esmolol, a selective β l antagonist, on postischemic contractile recovery. Drugs were given prophylactically.
Methods
Ischemia-reperfusion in isolated guinea pig hearts was induced by stopping the perfusion for 45 min and reperfusing for 60 min. Hearts (n = 7 in each group) were treated with or without propranolol (1 or 10μM), esmolol (5 or 50μM), or landiolol (20, 100 or 500 μM) ten minutes before inducing ischemia.
Results
At the end of reperfusion, left ventricular pressure (LVP) recovered to 64 ± 3% of the baseline value in the control group. With 1 and 10 μM propranolol, LVP recovered to 90 ± 5% and 100 ± 6% of the baseline value at 60 min after reperfusion, respectively. FiftyμM but not 5μM of esmolol resulted in restoration of LVP to 97 ± 17% of the pre-ischemic value at 60 min after reperfusion. In hearts pretreated with 100 and 500 μM landiolol, LVP was restored to 109 ± 5% and 104 ± 596 of the baseline value, respectively. Landiolol 100μM did not depress LVP in the pre-ischemic period.
Conclusions
The present study shows that landiolol, an ultrashort-acting cardioselective β l blocker, has cardioprotective effects on ischemia-reperfusion injury in isolated guinea pig hearts. All three β blockers were equally protective but the intermediate dosage of landiolol preserved LVP during the pre-ischemic period.
Résumé
Objectif
On croit que les bêtabloquants ont des effets bénéfiques sur le cœur ischémique. Les auteurs ont vérifié les effets du iandioioi (ONO 1101), un antagoniste βl hautement sélectif, du propranolol, un β bloquant non spécifique, et de l’esmolol, un antagoniste β l sélectif, sur la récupération contractile postischémique. Les médicaments ont été administrés préventivement.
Méthode
Lischémie-reperfusion a été induite dans des cœurs de cobaye isolés en stoppant la perfusion pendant 45 min et en reperfusant pendant 60 min. Les cœurs (n = 7 dans chaque groupe) ont été traités avec ou sans propranolol (1 ou 10 μM), esmolol (5 ou 50 μM) ou landiolol (20, 100 ou 500 μM) dix minutes avant l’induction de l’ischémie.
Résultats:À
La fin de la reperfusion, la pression ventriculaire gauche (PVG) avait retrouvé 64 ± 3 % de sa valeur de base dans le groupe témoin. Avec I et 10 μM de propranolol, la PVG a été récupérée respectivement à 90 ± 5 % et 100 ± 6 %, 60 min après la reperfusion. La dose de 50 μM, non celle de 5 μM, d’esmolol a été suivie de la restauration de la PVG à 91 ± 17% de la valeur préischémique, 60 min après la reperfusion. Dans les cœurs prétraités avec 100 et 500 μM de landiolol, la PVG a été restaurée à 109 ± 5 % et à 104 ± 5 % de sa valeur de base, respectivement. La dose de 100 μM de landiolol n’a pas causé de baisse de la PVG en période préischémique.
Conclusion
La présente étude montre que le landiolol, un β l bloquant cardiosélectif à action très brève, a des effets cardioprotecteurs sur les lésions résultant de l’ischémie-reperfusion dans des cœurs de cobaye isolés. Les trois β bloquants ont été également protecteurs, mais la dose intermédiaire de landiolol a diminué la PVG pendant la période préischémique.
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This study was supported in part by Grant-in-Aid No. C-12671487 from the Japan Society of the Promotion of Science, Tokyo, Japan.
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Kurosawa, S., Kanaya, N., Niiyama, Y. et al. Landiolol, esmolol and propranolol protect from ischemia/reperfusion injury in isolated guinea pig hearts. Can J Anesth 50, 489–494 (2003). https://doi.org/10.1007/BF03021062
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DOI: https://doi.org/10.1007/BF03021062