Conclusions
The current RCT evidence evaluating the effects of perioperative beta-blocker therapy on short and long-term cardiovascular outcomes has significant limitations. The results of these RCTs should be viewed as promising but tempered with healthy skepticism. In keeping with this the perioperative beta-blocker recommendations are weak as the reliability of the underlying evidence is weak. The POISE trial will provide definitive evidence to determine the efficacy of perioperative beta-blocker therapy.
Conclusion
L’argument de la présente ERC, évaluant les effets du traitement bêta-bloquant périopératoire sur les effets cardiovasculaires à court et long terme, présente des limites significatives. Les résultats des ERC doivent être vus comme prometteurs mais tempérés par un scepticisme prudent. Par conséquent, les recommandations sur les bêta-bloquants périopératoires sont faibles parce que la preuve sous-jacente est faible. L’étude POISE fournira une réponse définitive à la détermination de l’efficacité du traitement bêta-bloquant périopératoire.
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Sources of funding: Dr. P. J. Devereaux is supported by a Canadian Institutes of Health Research, Senior Research Fellowship Award.
Competing interests: Drs. P. J. Devereaux and Homer Yang are the Co Principal Investigators of the POISE trial. Dr. Kate Leslie is the POISE National Coordinator of Australia/Hong Kong/New Zealand/Singapore.
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Devereaux, P.J., Leslie, K. & Yang, H. The effect of perioperative beta-blockers on patients undergoing noncardiac surgery — is the answer in?. Can J Anesth 51, 749–755 (2004). https://doi.org/10.1007/BF03018446
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DOI: https://doi.org/10.1007/BF03018446