Abstract
Purpose
To compare oral tandospirone with oral clonidine in terms of preoperative anxiolysis.
Methods
Preoperative anxiety was measured using the Spielberger state-trait anxiety inventory (STAl-state). Pretreatment evaluation was performed on the day before surgery and posttreatment examination immediately after entry into the operating room. In a double-blind, randomized design, three groups of 40 patients received one of the following oral medications 90 min before entry into the operating room: 1) tandospirone 10 mg (T group); 2) clonidine 3 μg · kg−1 (C group); or 3) placebo (P group).
Results
Following premedication, the STAl-state decreased in the T group (P < 0.05) while exhibiting no significant changes in the C group. As far as the changes in the STAI-state were concerned, however, the P-group was different from each of the other groups (P < 0.05 vs T group and vs C group).
Conclusion
Oral tandospirone was equivalent to oral clonidine in terms of reduction in preoperative anxiety.
Résumé
Objectif
Comparer la tandospirone et la clonidine orales dans l’anxlolyse préopératoire.
Méthode
L’anxiété préopératoire a été mesurée à l’aide d’un questionnaire sur l’anxiété chronique et réactlonnelle de Spielberger (State-Trait Anxiety Inventory, STAl-state). L’évaluation prétraitement a été réalisée le jour avant l’opération et l’examen posttraitement, Immédiatement après l’entrée en salle d’opération. L’etude randomisée et à double Insu comportait 40 patients qui ont reçu l’une des médications orales suivantes 90 min avant d’entrer dans la salle d’opération: I) 10 mg de tandospirone (groupe T); 2) 3 μg · kg− 1 de clonidine (groupe C) ou 3) un placebo (groupe P).
Résultats
Après la prémédication, le STAI-state a baissé dans le groupe T (P < 0,05) et n’affichait aucun changement significatif dans le groupe C. Concernant les changements du STAI-state, le groupe P différait de chacun des autres groupes (P < 0,05 vs T et C).
Conclusion
L’administration orale de tandospirone ou de clonidine a été équivalente pour réduire l’anxiété préopératoire.
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This study was supported in part by Grant-in-Aid 12671460 from the Japan Society for the Promotion of Science.
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Iizawa, A., Oshima, T., Kasuya, Y. et al. Oral tandospirone and clonidine provide similar relief of preoperative anxiety. Can J Anesth 51, 668–671 (2004). https://doi.org/10.1007/BF03018423
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DOI: https://doi.org/10.1007/BF03018423