Abstract
The prophylactic antiemetic efficacy of combined granisetron and dexamethasone was evaluated in a randomized doubleblind manner in 88 patients undergoing general anaesthesia for major gynaecological surgery. Immediately after recovery from anaesthesia, patients received a single dose of either placebo (saline, n = 22), granisetron (20 μg · kg− 1, n = 22), dexamethasone (8 mg, n = 22) or combined granisetron and dexamethasone (20 μg · kg− 1 and 8 mg, respectively, n = 22) iv. The treatment groups were similar for patient demography, surgical procedures, anaesthetics administered and opioids given. Postoperatively, the frequency of nausea was 32%, 23%, 27% and 5% after administration of placebo, granisetron, dexamethasone and granisetron plus dexamethasone, respectively; the corresponding frequencies of vomiting were 23%, 23%, 23% and 5%. The incidence of adverse events postoperatively were not different among the groups. It is concluded that prophylactic administration of combined granisetron and dexamethasone is effective in preventing postoperative nausea and vomiting after anaesthesia.
Résumé
L’efficacité prophylactique de l’association granisetrondexaméthasone est évaluée dans une étude aléatoire à double insu chez 88 patientes soumises à une chirurgie gynécologique majeure sous anesthésie générale. Immédiatement après le réveil, les patientes reçoivent en dose unique, par la voie intraveineuse soit un placebo (sol. physiologique, n = 22), soit du granisetron (20 μg · kg− 1 n = 22), soit de la déxaméthasone (8 mg, n = 22) ou une association de granisetron et de déxaméthasone (20 μg · kg− 1 et 8 mg respectivement, n = 22). Les groupes de traitement sont identiques sur le plan démographique, pour l’intervention chirurgicale, l’anesthésie et les morphiniques administrés. A la période postopératoire, la fréquence de la nausée est de 32%, 23%, 27% et 5% respectivement, après le placebo, le granisetron, la déxaméthasone et l’association granisetron-dexaméthasone: la fréquence correspondante pour les vomissements est de 23%, 23%, 23% et 5%. L’incidence des incidents postopératoires n’est pas différente entre les groupes. On conclut que l’administration de l’association granisetron-dexaméthasone est très efficace pour la prévention des nausées et vomissements postoperatoires.
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This article has been retracted due to two reasons: Many variables reported in the studies are exceedingly unlikely. The author’s institution is not able to attest the integrity of the study and/or the data conducted under its auspices.
An erratum to this article can be found online at http://dx.doi.org/10.1007/s12630-012-9837-y.
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Fujii, Y., Tanaka, H. & Toyooka, H. RETRACTED ARTICLE: Granisetron-dexamethasone combination reduces postoperative nausea and vomiting. Can J Anaesth 42, 387–390 (1995). https://doi.org/10.1007/BF03015482
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DOI: https://doi.org/10.1007/BF03015482