Abstract
To determine the cardiovascular and respiratory effects of intravenous ketamine in the neonatal lamb we studied six unpremedicated chronic neonatal lamb preparations. Each lamb was anaesthetized with ketamine I mg·kg-1, allowed to recover and then anaesthetized with ketamine 2mg·kg-1. Mean arterial pressure, mean pulmonary artery pressure, mean left atrial pressure, pulmonary blood flow, heart rate, respiratory rate and arterial blood gases were measured before and at one, two, four, six, eight and ten minutes after the administration of each dose of ketamine. Pulmonary vascular resistance, systemic vascular resistance and the ratio of pulmonary to systemic vascular resistance were also determined. After the administration of either dose of ketamine, only respiratory rate changed significantly (p ≤ 0.05), reaching a maximum after two minutes. This change was not associated with any arterial blood gas abnormalities. We conclude that in the presence of adequate ventilation, ketamine produces no significant cardiovascular effects in neonatal lambs.
Résumé
Afin de déterminer les effets respiratoires et cardiovasculaires de l’injection intra-veineuse de kétamine chez l’ agnelet ont a étudié six préparations non prémédiquées. Chaque agnelet a été anesthésié avec la kétamine 1 mg·kg-1 puis après le réveil ré-anesthésié avec 2 mg·kg-1. La tension artérielle moyenne, la pression moyenne de l’artère pulmonaire, la pression moyenne de l’oreillette gauche, le flot pulmonaire sanguin, la fréquence cardiaque, la fréquence respiratoire, les gaz sanguins, ont été mesuré avant et après une, deux, quatre, six, huit et dis minutes de l’administration de chaque dose de kétamine. La résistance vasculaire pulmonaire, la résistance vasculaire systémique et leur rapport ont été déterminées. Après l’administration de la dose de kétamine, seule la fréquence respiratoire a changé significativement (p < 0.05) atteignant un maximun après deux minutes. Ce changement n’était pas associé avec des anomalies des gaz sanguins. On conclut qu’en présence d’une ventilation adéquate, la kétamine ne produit pas d’effets cardiovasculaires significatifs chez les agnelets.
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Burrows, F.A., Norton, J.B. & Fewel, J. Cardiovascular and respiratory effects of ketamine in the neonatal lamb. Can Anaesth Soc J 33, 10–15 (1986). https://doi.org/10.1007/BF03010902
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DOI: https://doi.org/10.1007/BF03010902