Abstract
This study was undertaken to assess the efficacy of a single preoperative dose of naproxen sodium in reducing postoperative pain and length of day surgery stay in patients undergoing arthroscopic knee surgery. A randomized, double-blind clinical trial was carried out on 66 ASA I and ASA II patients scheduled for arthroscopic knee surgery. The treatment group (n = 26) received two capsules containing 275 mg of naproxen sodium each, and the control group (n = 40) received placebo. Preoperative and postoperative visual analogue pain scores, postoperative analgesic requirements in hospital as well as 24 hr after discharge, and length of day surgery stay were studied. There was a decrease in postoperative pain, both in hospital (naproxen 0.7 ±1.2 vs placebo 2.2 ±2.3) and at 24 hr after discharge (naproxen 0.8 ±1.9 vs placebo 3.8 ±3.2) (P = 0.0001). There was no difference in the need for in-hospital postoperative analgesics or in the time to discharge. However, there was a difference in the use of analgesics after discharge (naproxen group 30.4% vs placebo group 71.4%) (P < 0.01). The results of this study suggest that a single preoperative dose of 550 mg naproxen sodium is effective in reducing postoperative pain in arthroscopic knee surgery, both in the immediate postoperative period and for up to 24 hr after the completion of surgery.
Résumé
Cette étude vise à évaluer l’efficacité d’une dose préopératoire unique de naproxène sodique administrée pour diminuer la douleur postopératoire et la durée du séjour hospitalier en chirurgie d’un jour chez des patients qui subissent une chirurgie arthroscopique du genou. Une étude randomisée et à double insu est réalisée chez 66 ASA I et ASA II programmés pour une chirurgie du genou par arthroscopie. Chaque membre du groupe traitement (n = 26) reçoit deux capsules contenant 275 mg de naproxène sodique alors que le groupe contrôle (n = 40) reçoit un placébo. Des échelles visuelles analogues pré-et postopératoire, les besoins analgésiques postopératoires et la durée du séjour font l’objet de l’étude. L’intensité de la douleur postopératoire diminue aussi bien à l’hôpital (naproxène 0,7 ±1,2 vs placébo 2,2 ±2,3) que 24 h après le congé (naproxène 0,8 ±1,9 vs placébo 3,8 ±3,2; P = 0.001). Quant au besoin d’analgésiques postopératoires, on ne trouve pas de différence pendant le séjour hospitalier ou au moment du congé. Cependant, on note une différence pour l’utilisation d’analgésiques après le congé (naproxène 30,4% vs plaébo 71,4%, P < 0,01). Les résultats de cette étude suggèrent l’efficacité d’une seule dose préopératoire de 550 mg de naproxène sodique pour réduire la douleur postopératoire en chirurgie arthroscopique du genou dans la période postopératoire immédiate et jusqu’à 24 h après la complétion de la chirurgie.
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Code, W.E., Yip, R.W., Rooney, M.E. et al. Preoperative naproxen sodium reduces postoperative pain following arthroscopic knee surgery. Can J Anaesth 41, 98–101 (1994). https://doi.org/10.1007/BF03009799
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DOI: https://doi.org/10.1007/BF03009799