Abstract
The purpose of the study was to compare the response of the cricoarytenoideus dorsalis muscle (CD) to neuromuscular blocking drugs with those of the thyroarytenoideus (TA), diaphragm (DI) and ulnaris lateralis (UL) muscles. Evoked electromyographic response to indirect supramaximal stimulation at 1 Hz was monitored in ten adult goats under thiopentone-halothane anaesthesia. The onset time and duration of neuromuscular blockade after intravenous administration of 500 μg · kg−1 of succinylcholine or 4 μg · kg−1 of vecuronium were determined. Times to 100% paralysis in CD, TA, DI and UL after succinylcholine were (mean ± SD) 39 ± 11, 39 ± 11, 42 ± 8 and 57 ± 8 seconds, respectively; the corresponding times for vecuronium were 5.6 ± 2.3, 4.6 ± 1.7, 6.0 ± 1.9 and 9.6 ± 1.7 min. The order of recovery to 25% spontaneous EMG activity was TA, CD, DI and UL after succinylcholine (durations: 9.7 ± 3.6, 11.0 ± 3.0, 15.3 ± 1.3 and 22.0 ± 1.2 min, respectively) but DI, CD, TA and UL after vecuronium (durations: 31.9 ± 18.6, 35.2 ± 19.5, 47.1 ± 19.9 and 71.7 ± 16.1 minutes, respectively). Thus, as in the diaphragm and thyroarytenoideus muscles, onset time and duration of succinylcholine or vecuronium blockade were shorter in the abductor muscle of the glottis, cricoarytenoideus dorsalis, than in the limb muscle.
Résumé
Cette étude vise à comparer la réponse du muscle cricoaryténoïdien postérieur (CD) à celle des muscles thyroaryténoïdien (TA), diaphragmatique (DI) et cubital externe (UL). La réponse électromyographique à une stimulation indirecte supramaximale de 1 Hz est monitorée chez dix boucs adultes sous anesthésie au thiopentone-halothane. On détermine le début de l’installation et la durée du bloc neuromusculaire après l’administration iv soit de succinylcholine 500 μg · kg−1, soit de vécuronium 4 μg · kg−1. L’intervalle pour atteindre 100% de paralysie pour CD, TA, DI et UL après succinylcholine est respectivement de (moyenne ± SD) 39 ± 11, 39 ± 11, 42 ±8 et 57 ± 8 secondes; les valeurs correspondantes pour le vécuronium sont de 5,6 ± 2,3, 4,6 ± 1,7, 6,0 ± 1,9 et 9,6 ± 1,7 min. La récupération spontanée de l’activité EMG à 25% se fait dans l’ordre suivant: après succinylcholine: TA, CD, DI et UL (durées respectives: 9,7 ± 3,6, 11,0 ± 3,0, 15,3 ± 1,3 et 22 ± 1,2 min); après vécuronium DI, CD, TA, et UL (durées respectives: 31,9 ± 18,6, 35,2 ± 19,5, 47,1 ± 16,1 min). Donc, comme pour le diaphragme et les muscles thyro-aryténoïdiens, le début de l’installation et la durée du bloc produit par la succinylcholine ou le vécuronium sont plus courts pour les muscles abducteurs de la glotte, les cricoaryténoïdiens postérieurs, que pour les muscles du membre supérieur.
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This work was supported in part by grants from the Charles Slater Fund and the Jowett Fund of the University of Cambridge. C.I. was in receipt of the Blue Circle Cambridge Commonwealth Scholarship, an Overseas Research Students (ORS) Award and was an honorary scholar of the Hyam Wingate Foundation.
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Ibebunjo, C., Hall, L.W. Succinylcholine and vecuronium blockade of the diaphragm, laryngeal and limb muscles in the anaesthetized goat. Can J Anaesth 41, 36–42 (1994). https://doi.org/10.1007/BF03009659
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DOI: https://doi.org/10.1007/BF03009659