Abstract
Preoperative cimetidine 300 mg or ranitidine in 50 and 100 mg doses were administered intramuscularly to 120 patients in a randomized double-blind study. The volume and pH of gastric aspirate samples obtained after tracheal intubation and before extubation were measured. The pH of gastric aspirate was higher following ranitidine 100 mg than ranitidine 50 mg or cimetidine 300 mg at both intubation and extubation (p = 0.006). In addition, fewer patients tended to be“at risk”of pulmonary aspiration syndrome (pH ⩽ 2.5) after ranitidine 100 mg than ranitidine 50 mg or cimetidine 300 mg.
Preoperative intramuscular ranitidine 100 mg was found to be suitable for use in protection against gastric aspiration syndrome.
Résumé
Dans une étude à double insu ponant sur 120 malades, on a comparé les effets sur le volume et le pH du suc gastrique de la cimétidine 300 mg à ceux de la ranitidine à la dose de 50 et 100 mg administrée par voie intramusculaire avant l’intervention. Les mesures de volume et de pH gastrique ont été effectuées après l’ intubation et avant l’extubation.
Le pH du suc gastrique était plus élevé à la suite de ranitidine 100 mg comparé à la ranitidine 50 mg ou la cimétidine 300 mg au moment de l’intubation et de l’extubation (p = 0.006). En outre, il y avait moins de patients jugés en risque“d’aspiration en puissance”(pH ⩽ 2.5) dans le groupe traité à la ranitidine 100 mg que dans le groupe ranitidine 50 mg ou cimétidine 300 mg.
Il apparaît donc que la ranitidine 100 mg administrée par voie intra-musculaire constitue un agent efficace de protection contre le syndrome d’aspiration gastrique.
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Supported by a grant-in-aid from Glaxo Canada Limited. Presented at Canadian Anaesthetists’ Society Annual Meeting, Vancouver, 1983.
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Harris, P.W., Morison, D.H., Dunn, G.L. et al. Intramuscular cimetidine and ranitidine as prophylaxis against gastric aspiration syndrome - a randomized double-blind study. Can Anaesth Soc J 31, 599–603 (1984). https://doi.org/10.1007/BF03008753
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DOI: https://doi.org/10.1007/BF03008753