Abstract
The metabolism of isoflurane and the investigational volatile anaesthetic desflurane to fluoride ion was examined in 25 surgical patients. The patients were randomly assigned to four groups, to receive isoflurane or desflurane at either 0.65 MAC or 1.25 MAC. Anaesthesia was induced in all patients with thiopentone and midazolam and included nitrous oxide 60% in addition to the volatile agent. Blood was drawn before induction and at the end of the operation for determination of serum fluoride ion concentration. Plasma fluoride ion concentrations increased (+1.36 ± 0.93 μM, P < 0.01) in patients receiving isoflurane but were unchanged (− 0.13 ± 0.50 μM) in patients receiving desflurane. Metabolic release of fluoride ion is less with desflurane than with isoflurane during administration of the anaesthetics to surgical patients, and is unlikely to be of clinical significance.
Résumé
Le métabolisme de l’isoflurane et de l’anesthésique volatil sous investigation le desflurane en ion fluorure fut examiné chez 25 patients chirurgicaux. Les patients furent randomisés et divisés en quatre groupes afin de recevoir l’isoflurane ou le desflurane à soit 0,65 MAC ou 1,25 MAC. L’anesthésie fut induite chez tous les patients avec du thiopentone et du midazolam incluant du protoxyde d’azote 60% avec l’agent volatil. Du sang fut prélevé avant l’induction et à la fin de l’opération afin de déterminer la concentration d’ion fluorure sérique. Des concentrations des ions fluorure plasmatique augmentèrent (+ 1,36 ± 0,93 μM, P < 0,01) chez les patients recevant l’isoflurane mais furent inchangées (− 0,13 ± 0,50 μM) chez les patients recevant la desflurane. La libération métabolique de l’ion fluorure est moindre avec la desflurane que l’isoflurane durant l’administration de l’anesthésie chez les patients chirurgicaux et n’aura probablement pas de signification clinique.
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This work was supported in part by funding from Anaquest Corp., Division of BOC Inc.
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Smiley, R.M., Ornstein, E., Pantuck, E.J. et al. Metabolism of desflurane and isoflurane to fluoride ion in surgical patients. Can J Anaesth 38, 965–968 (1991). https://doi.org/10.1007/BF03008612
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DOI: https://doi.org/10.1007/BF03008612