Abstract
The baroreceptor response was evaluated in newborn and adult rabbits by the pressortest of Smyth during the administration of oxygen and nitrous oxide. Newborn rabbits were found to have an attenuated baroreceptor reflex in comparison to adults. In addition, their reflex was more susceptible to the depressant effect of nitrous oxide. The newborn may be particularly at risk of cardiovascular compromise during anaesthesia and acute stress due to the dependence of cardiac output on heart rate.
Résumé
On a évalué la sensibilité du réflexe barorécepteur du lapin nouveau-né et adulte par l’épreuve de Smyth pendant l’administration d’oxygène et de protoxyde d’azote. Comparativement aux lapins adultes on a trouvé que les nouveaux-nés avaient un réflexe barorécepteur atténué. De plus ce réflexe était plus sensible à l’effet dépresseur du protoxyde d’azote. Le nouveau-né peut done être plus particulièrement en danger de collapsus cardio-vasculaire pendant l’anesthésie et le stress à cause de la dépendance de son débit cardiaque sur la fréquence cardiaque.
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References
Braunwald, E. Regulation of the Circulation. New Eng. J. Med.290: 1124–1129 (1974).
Vatner, S.F. &Braunwald, E.Cardiovascular Control Mechanisms in the Conscious State. New Eng. J. Med.293: 970–976 (1975).
Gregory, G.A. Baroreceptors and Anesthesia in Infants < 1.5 g at Birth Abstracts of Scientific Program: page 375 (1978). Annual Meeting of the American Society of Anesthesiologists: Chicago, Illinois.
Smyth, H.S., Sleight, P. &Pickering, G.W. Reflex Regulation of Arterial Pressure during Sleep in Man. Circ. Res.24: 109–121 (1969).
Wade, J.G. &Larson, P.C. Effect of Carotid Endarterectomy on Carotid Chemoreceptor and Baroreceptor Function in Man. New Eng. J. Med.282: 823–829 (1970).
Bristow, J.D., Honour, J., Pickering, G.W., Sleight, P. &Smyth, T. Diminished Baroreflex Sensitivity in High Blood Pressure. Circulation39: 48–54 (1969).
Duke, P.C, Wade, J.G., Hickey, R.F. &Larson, P.C. The Effects of Age on Baroreceptor Reflex Function in Man. Canad. Anaesth. Soc. J.23: 111–124 (1976).
Eckberg, D.L., Drabinsky, M. &Braunwald, E. Defective Cardiac Parasympathetic Control in Patients with Heart Disease. New Eng. J. Med.285: 877–883 (1971).
Higgins, C.B., Vatner, S.F., Eckberg, D.L. &Braunwald, E. Alterations in the Baroreceptor Reflex in Conscious Dogs with Heart Failure. J. Clin. Invest.51: 715–724 (1972).
Rudolph, A.Congenital Disease of the Heart, p. 1–48, 1974. Yearbook Medical Publications, Chicago.
Duke, P.C., Fownes, D. &Wade, J.G. Halothane Depresses Baroreflex Control of Heart Rate in Man. Anesthesiology46: 184–187 (1977).
Eckenhoff, J.G. &Oech, S.R.L. The Effects of Narcotics and Antagonists Upon Respiration and Circulation in Man. A Review. Clin. Pharm. Therap.1: 483–524 (1960).
Skovsted, P., Price, M.L. &Price, H.L. The Effects of Short-Acting Barbiturates on Arterial Pressure, Preganglionic Sympathetic Activity, and Barostatic Reflexes. Anesthesiology33: 10–18 (1970).
Mittler, G. &Wade, J. The Effect of Methoxyflurane on Baroreceptor Control of Heart Rate in Man. Canad. Anaesth. Soc. J.19: 60–65 (1972).
Gregory, G.A., Eger, E.I. &Munsen, E.S. The Relationship between Age and Halothane Requirement in Man. Anesthesiology30: 488–491 (1969).
Ware, S., Robinson, S. &Gregory, G.A. Effect of Halothane on Baroreceptor Response in Newborn and Adult Rabbits. Anesthesiology: In Press.
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Duncan, P.G., Gregory, G.A. & Wade, J.G. The effect of nitrous oxide on baroreceptor function in newborn and adult rabbits. Canad. Anaesth. Soc. J. 28, 339–341 (1981). https://doi.org/10.1007/BF03007800
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DOI: https://doi.org/10.1007/BF03007800