Abstract
The cardiovascular effects of midazolam (0.15 mg kg-) and thiopentone (3.0 mg kg1) were compared during induction of anaesthesia in 20 American Society of Anesthesiologists class HI patients. In patients given thiopentone (N = 11), cardiac output, mean arterial pressure, heart rate, and systemic vascular resistance all decreased significantly over the course of the study period; mean right atrial pressure rose slightly, and stroke volume remained the same. Patients receiving midazolam (N = 9) experienced similar haemodynamic changes which were significant relative to baseline only for the fall in mean arterial pressure and the rise in mean right atrial pressure at ten minutes. There were no significant differences between the two groups. Midazolam thus appears to be at least as acceptable an induction agent as thiopentone in ill patients, from a haemoaynamic point of view.
Résumé
On a comparé les effets cardiovasculaires obtenus pendant I’administration de I’anesthésie avec le midazolam (0.15 mg kg-1) et le thiopentone (30 mg kg1) chez 20patients appartenant ä la Classe III (American Society of Anesthesiologists). Chez les patients recevant le thiopentone (N = 11), on a observé que le débit cardiaque, la fréquence cardiaque, la résistance vasculaire générale et la tension artérielle ont baissé sensiblement durant le cours de notre recherche. La pression moyenne de I’auriculaire cardiaque droite haussa faiblement tandis que le débit systolique resta le même. Les patients auxquels on administra le midazolam (N = 9) ont éprouvé des changements hémodynamiques significatifs par rapport à la valeur de base oi l’on observa settlement une baisse de la pression artérielle moyenne et une hausse à dix minutes de la pression moyenne de l’ auriculaire cardiaque droite. Il n’y a done pas áe différences significatives entre les deux groupes. Le midazolam apparaît être un agent d’induction aussi acceptable que le thiopentone chez les malades, au point de vue hémodynamique.
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Lebowitz, P.W., Cote, M.E., Daniels, A.L. et al. Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in Ill surgical patients. Can Anaesth Soc J 30, 19–23 (1983). https://doi.org/10.1007/BF03007711
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DOI: https://doi.org/10.1007/BF03007711