Abstract
The purpose of this study was to examine the relationship of continuous sufentanil infusion (0.71 μg · kg−1 · min−1 for 14 min) and the response of the power spectrum of the electroencephalogram (EEG) performed during the induction of anaesthesia in 12 patients undergoing CABG surgery. Data were collected at various times including the preinduction period, every minute during the infusion period (minute 0 to 14), and 15, 20 and 25 min after the start of the infusion (1,6 and 11 min respectively after completion of the infusion). Within three minutes of the sufentanil infusion, the total power and the relative power of delta increased to near maximum, while the 95% spectral edge and the mean frequency decreased markedly. In spite of the continued infusion of sufentanil, there were very little further changes in the EEG activity. This ceiling effect for the EEG changes appear to coincide with the failure to respond to verbal command. We conclude that the power spectrum of the EEG failed to respond to increasing doses of sufentanil during its infusion after the rapid initial changes.
Résumé
Le but de cette étude était d’examiner la relation d’une perfusion continue de sufentanil (0.71 μg · kg−1 · min−1 pour 14 min) et la réponse du spectre de puissance de l’ électroencéphalogramme (EEG) obtenue durant l’induction de l’anesthésie chez douze patients devant subir un pontage aortocoronarien. Les données furent obtenues à des temps differents incluant la période de préinduction, chaque minute durant la perfusion (minute 0 à 14), et 15, 20 et 25 minutes après le debut de la perfusion (1, 6 et 11 minutes respectivement apres la cessation de la perfusion). En dedans de trois minutes de la perfusion de sufentanil, la puissance totale et la puissance relative de l’onde delta augmenta pour presqu’ atteindre le maximum, alors que la crête spectrale de 95% et la fréquence moyenne out diminué d’une façon marquée. Malgré la perfusion continue de sufentanil, il n’y avait que tres peu d’altération dans l’activité de l’EEG. Cet effet de plafonnement pour les alterations de l’EEG coïncide approximativement avec la non-réponse à la commande verbale. On conclut que la spectre de puissance de l’EEG a manqué de répondre à l’augmentation de la dose de sufentanyl lors de sa perfusion après les changements rapides initianx.
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Chi, O.Z., Sommer, W. & Jasaitis, D. Power spectral analysis of EEG during sufentanil infusion in humans. Can J Anaesth 38, 275–280 (1991). https://doi.org/10.1007/BF03007614
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DOI: https://doi.org/10.1007/BF03007614