Summary
The effects of physostigmine on reversal of post-operative somnolence following general anaesthesia were evaluated in 187 patients. Significant reversal of anaesthetic-induced post-operative somnolence was observed in those patients receiving physostigmine when compared to a control group. These results suggest that general anaesthesia with halothane may be included in those situations where central nervous system depression may be reversed by administration of physostigmine. Cholinergic side-effects observed with physostigmine administration were minimal.
RéSUMé Ľinfluence de la physostigmine sur ľéveil de ľanesthésie a été évaluée chez cent patients en bonne santé (classe I — ASA). Comparés à un groups contrôle de 87 malades, les patients ayant reçu de la physostigmine ont résupéré plus rapidement de ľétat de somnolence secondaire à ľanesthésie générale.
Ces résultats suggèrent que la physostigmine peut renverser ľétat de somnolence secondaire à une anesthésie générale.
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Hill, G.E., Stanley, T.H. & Sentker, C.R. Physostigmine reversal of postoperative somnolence. Canad. Anaesth. Soc. J. 24, 707–711 (1977). https://doi.org/10.1007/BF03006714
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DOI: https://doi.org/10.1007/BF03006714