Summary
Forty dogs were studied during MAC-I halothane anaesthesia with a chronically implanted electromagnetic flow probe on the ascending aorta. Cardiac output, stroke volume. heart rate, mean arterial pressure, pulse pressure, central venous pressure and total peripheral resistance were determined in addition to\(Pa_{o_2 } \). pH,\(Pa_{co_2 } \) and base deficit.
Acupuncture moxibustion with electrocautery at Jen Chung (Go-26) produced a significant (five per cent level) increase in the cardiac output, stroke volume, heart rate, mean arterial pressure and pulse pressure and a significant decrease in total peripheral resistance during a 120-minute period of observation in dogs under halothane anaesthesia. Acupuncture moxibustion at Go-26 following pretreatment with the narcotic antagonist naloxone (1 mg · kg-1) produced a significant increase in cardiac output, heart rate, mean arterial pressure, pulse pressure and central venous pressure. It is concluded that naloxone, which inhibits the analgesic effects of acupuncture, does not inhibit the sympathomimetic effect of acupuncture or moxibustion at Jen Chung (Go-26) in dogs under light MAC-I halothane anaesthesia.
Résumé
Ľétude porte sur 40 chiens anesthésiés à ľhalothane (MAC-I) porteurs de débitmètres électromagnétiques implantés dans ľaorte ascendante. Le débit cardiaque, le volume ďéjection, la fréquence cardiaque, la pression artérielle moyenne et différentielle, la tension veineuse centrale, la résistance périphérique totale ont été déterminés ainsi que la\(Pa_{co_2 } \), le pH, la\(Pa_{co_2 } \) et le déficit de base.
La moxibustion associée à ľacupuncture obtenues par électrocautérisation du point Jen Chung (Go-26) a produit une augmentation significative de ľordre de cinq pour cent de tous les paramètres vasculaires, à ľexception de la résistance périphérique totale qui a subis une baisse significative pendant la période ďobservation de 120 minutes des chiens anesthésiés à ľhalothane. Ľacupuncture-moxibustion au point Go-26 après traitement préalable à ľantagoniste narcotique naloxone (1 mg · kg-1) a été suivie ďune augmentation significative du débit cardiaque, de la fréquence, de la pression artérielle moyenne et différentielle ainsi que de la pression veineuse centrale. On en conclut que la naloxone qui inhibe les effets analgésiques de ľacupuncture, ne cause pas ďinhibition des effets sympathycomimétiques de ľacupuncture ou de la moxibustion à Jen Chung (Go-26) chez les chiens anesthésiés légèrement à ľhalothane (MAC-I).
Article PDF
Similar content being viewed by others
References
Andersson, S.A., Ericson, T., Holmgren, E. &Lindgrist, G. Electro-acupuncture. Effect on pain threshold measured with electrical stimulation of teeth. Brain Res.63: 393 (1973).
Leung, S.J., Fan, C.F. &Sechzer, P.H. Acupuncture therapeutics. Anaesth. Analg. (Cleve)53: 942 (1974).
Mann, F., Bowsher, D., Mumforo, J., Lipton, S. &Miles, J. Treatment of intractable pain by acupuncture. Lancet2: 57 (1973).
Nemerof, H. Clinical experiences with acupuncture. J. Am. Osteopath. Assoc.71: 866 (1972).
Peng, A.T.C., Omura, Y., Cheng, H.C. &Blancato, L.S. Acupuncture for relief of chronic pain and surgical analgesia. Am. Surg.40: 50 (1974).
Spoerel, W.E. &Leung, C.Y. Acupuncture in a pain clinic. Can. Anaesth. Soc. J.21: 221 (1974).
Wallis, L., Snyder, S.M., Palahniuk, R.J. &Spivey, H.T. An evaluation of acupuncture analgesia in obstetrics. Anesthesiology41: 596 (1974).
Lee, D.C., Lee, M.O. &Clifford, D.H. Cardiovascular effects of moxibustion at Jen Chung (Go-26) during halothane anesthesia in dogs. Am. J. Chinese Med.3: 245 (1975).
Lee, M.O., Lee, D.C., Kim, S. &Clifford, D.H. Cardiovascular effects of acupuncture at Tsu San Li (St-36) in dogs. J. Surg. Res.18: 51 (1975).
Lee, D.C., Lee, M.O., Clifford, D.H. &Morris, L.E. Inhibition of the cardiovascular effects of acupuncture (moxibustion) by propranolol in dogs during halothane anesthesia. Can. Anaesth. Soc. J.23: 307 (1976).
Lee, M.O., Lee, D.C. &Clifford, D.H. Inhibition of the cardiovascular effects on acupuncture (moxibustion) by phentolamine in dogs during halothane anesthesia. Am. J. Chinese Med.4: 153 (1976).
Clifford, D.H., Lee, M.O. &Lee, D.C. Cardiovascular effects of atropine on acupuncture, needling with electrostimulation, at Tsu San Li (St-36) in dogs. Am. J. Vet. Res.38: 845 (1977).
Cox, B.M., Opheim, K.E., Teschemacher, H. &Goldstein, A. A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties. Life Sci.16: 1777 (1975).
Hughes, J. Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Res.88: 295 (1975).
Teschenmacher, H., Opheim, K.E., Cox, B.M. &Goldstein, A. A peptide-like substance from pituitary that acts like morphine. I. Isolation. Life Sci.16: 1771 (1975).
Ross, M., Dingledine, R., Cox, B.M. &Goldstein, A. Distribution of endorphins (Peptides with morphine-like pharmacological activity in pituitary). Brain Res.124: 523 (1977).
Mayer, D.J., Price, D.D. &Raffii, A. Antagonism of acupuncture analgesia in man by the narcotic antagonist naloxone. Brain Res.121: 368 (1977).
Pomeranz, B., Cheng, R. &Law, P. Acupuncture reduces electrophysiological and behavioral responses to noxious stimuli: Pituitary is implicated. Exp. Neurol.54: 172 (1977).
Pert, A. &Yaksh, T. Sites of morphine-induced analgesia in the primate brain: Relation to brain pathways. Brain Res.80: 135 (1974).
Terenius, L. &Wahlstrom, A. Morphine-like ligand for opiate receptors in human CSF. Life Sci.16: 1759 (1975).
Hughes, J. Search for the endogenous ligand of the opiate receptor. Neurosci. Res. Program Bull13: 55 (1975).
Snyder, S.H. The brain’s own opiates. Chem. & Engineering News55: 26 (1977).
Pomeranz, B. &Chiu, D. Naloxone blockade of acupuncture analgesia: endophin implicated.Life Sci. 19: 1757 (1976).
Goodman, L.S. &Gilman, A. The Pharmacological Basis of Therapeutics, 4th Ed., The Macmillan Co., New York, N. Y. (1970).
Meyers, F.H., Jawets, E. &Goldfien, A. Review of Medical Pharmacology, Lange Medical Publication, Los Altos, California (1976).
Conn, Howard, F. Current Therapy, W.B. Saunders Company, Philadelphia (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lee, D.C., Ichiyanagi, K., Lee, M.O. et al. Can naloxone inhibit the cardiovascular effect of acupuncture?. Canad.Anaes.Soc.J. 26, 410–414 (1979). https://doi.org/10.1007/BF03006456
Issue Date:
DOI: https://doi.org/10.1007/BF03006456