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Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection

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Abstract

The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT.Methods: Ten normal liver controls and 44 liver tumor patients who underwent sectorial hepatectomy were included in the study.99mTc-GSA dynamic SPECT study was performed 7±3 d before (pre-operative) and 34±13 d after surgery (post-operative) in liver tumour patients. Pre- and post-operative parameters including hepatic functional volume and99mTc-GSA clearance of unit hepatic functional volume, representing ASGP-R concentration, were measured. The sum of functional volume of the sectors uninvolved in hepatectomy was defined as residual functional volume. Subsequently, post-operative change in functional volume (the ratio of post-operative to residual functional volume), post-operative change in99mTc-GSA clerance of unit hepatic functional volume (the ratio of post- to pre-operative99mTc-GSA clearance of unit hepatic functional volume) and percent resection of functional volume were calculated.Results: Pre-operative99mTc-GSA clerance of unit hepatic functional volume in tumor-bearing livers was significantly lower than that in non-tumor bearing control liver. The ratio of post- to pre-operative99mTc-GSA clerance of unit hepatic functional volume showed marked variation from 0.57 to 2.14, which negatively correlated with the percent resection of functional volume (r=-0.58, p<0.0001). The ratio of post- to pre-operative99mTcGSA clearance of unit hepatic functional volume exhibited a negative correlation with the ratio of post-operative to estimated residual functional volume (r=-0.67, p<0.0001).Conclusion: ASGP-R concentration is reduced in the presence of liver tumor. ASGP-R concentration reveals variable changes early after sectorial resection; the change negatively correlates with percent resection of hepatic functional volume. Post-operative change in ASGP-R concentration negatively correlates with change in functional volume.

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References

  1. Ashwell G Steer CJ. Hepatic recognition and catabolism of serum glycoproteins.JAMA 1981; 246: 2358–2364.

    Article  PubMed  CAS  Google Scholar 

  2. Stockert RJ Morell AG. Hepatic binding protein: the galactose-specific receptor of mammalian hepatocytes.Hepatology 1983; 3: 750–757.

    PubMed  CAS  Google Scholar 

  3. Ha-Kawa SK Tanaka Y. A quantitative model of99mTc-DTPA-galactosy-HSA for the assessment of hepatic blood flow and hepatic binding receptor.J Nucl Med 1991; 32: 2233–2240.

    PubMed  CAS  Google Scholar 

  4. Kudo M, To-do A, Ockelbo K, Yamamoto K, Vera DR, Satanic RC. Quantitative assessment of hepatocellular function throughin vivo radioreceptor imaging with technetium 99m galactosyl human serum albumin.Hepatology 1993; 17: 814–819.

    PubMed  CAS  Google Scholar 

  5. Kwon AH, Ha-kawa SK, Uetsuji S, Inoune T, Matsui Y, Kamiyama Y. Preoperative determination of the surgical procedure for hepatectomy using technetium-99m galactosyl-human serum albumin (99mTc-GSA) liver scintigraphy.Hepatology 1997; 25: 426–429.

    Article  PubMed  CAS  Google Scholar 

  6. Shuke N, Aburano T, Nakajima K, Yokoyama K, Sun BF, Matsuda H, et al. The utility of quantitative99mTc-GSA liver scintigraphy in the evaluation of hepatic functional reserve: comparison with99mTc-PMT and99mTc-Sn colloid.KAKU IGAKU (Jpn J Nucl Med) 1992; 29: 573–584.

    CAS  Google Scholar 

  7. Hwang E-H, Taki J, Shuke N, Nakajima K, Kinuya S, Konishi S et al. Preoperative assessment of residual hepatic functional reserve using99mTc-DTPA-galactosyl-human serum albumin dynamic SPECT.J Nucl Med 1999; 40: 1644–1651.

    PubMed  CAS  Google Scholar 

  8. Kokudo N, Vera DR, Koizumi M, Seki M, Sato T, Stadalnik RC, et al. Recovery of hepatic asialoglycoprotein receptors after major hepatic resection.J Nucl Med 1999; 40: 137–141.

    PubMed  CAS  Google Scholar 

  9. Imaeda T, Kanematsu M, Asada S, Seki M, Doi H, Saji S. Utility of Tc-99m GSA SPECT imaging in estimation of functional volume of liver segments in health and liver diseases.Clin Nucl Med 1995; 20: 322–328.

    Article  PubMed  CAS  Google Scholar 

  10. Daneker GW, Talamonti MS. Cancers of the liver. In: Morris PJ, Wood WC, eds.Oxford Textbook of Surgery. 2nd ed. Oxford, England; Oxford University Press, 2000: 1631–1652.

    Google Scholar 

  11. Mitsumori A, Nagaya I, Kimoto S, Akaki S, Togami I, Takeda Y, et al. Preoperative evaluation of hepatic functional reserve following hepatectomy by technetium-99m galactosyl human serum albumin scintigraphy and computed tomography.Eur J Nucl Med 1998; 25: 1377–1382.

    Article  PubMed  CAS  Google Scholar 

  12. Patlak CS, Blasberg RG. Graphical evaluation of blood-brain transfer constants from multiple-time uptake data. Generalizations.J Cereb Blood Flow Metabol 1985; 5: 584–590.

    CAS  Google Scholar 

  13. Nott DM, Grime SJ, Yates J, Baxter JN, Cooke TG, Jenkins SA. Changes in hepatic haemodynamic in rats with overt liver tumour.Br J Cancer 1991; 64: 1088–1092.

    PubMed  CAS  Google Scholar 

  14. Martinez-Hermandez A, Delgado FM, Amenta PS. The extracelluar matrix in hepatic regeneration: localization of collagen types I, II, IV, laminin and fibronectin.Lab Invest 1991; 64: 157–166.

    Google Scholar 

  15. Michalopoulos GK, DeFrances MC. Liver regeneration.Science 1997; 276: 60–66.

    Article  PubMed  CAS  Google Scholar 

  16. Schwartz AL, Fridovich SE, Lodish HF. Kinetics of internalization and recycling of asialoglycoprotein receptor in a hepatoma cell line.J Biol Chem 1982; 257: 4230–4237.

    PubMed  CAS  Google Scholar 

  17. Wood AJJ, Villeneuve JP, Branch RA, Rogers LW, Shand DG. Intact hepatocyte theory of impaired drug metabolism in experimental cirrhosis in the rat.Gastroenterology 1979; 76: 1358–1362.

    PubMed  CAS  Google Scholar 

  18. Miki K, Kubota K, Inoue Y, Vera DR, Makuuchi M. Receptor measurements via Tc-GSA kinetic modeling are proportional to functional hepatocellular mass.J Nucl Med 2001; 42: 733–737.

    PubMed  CAS  Google Scholar 

  19. Sugai Y, Komatani A, Hosoya T, Yamaguchi K. Response to percutaneous transhepatic portal embolization: new proposed parameters by99mTc-GSA SPECT and their usefulness in prognostic estimation after hepatectomy.J Nucl Med 2000; 41: 421–425.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Raotracer Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takaramachi, 920-8640, Kanazawa, Japan

    Xiao-Feng Li, Junichi Taki, Seigo Kinuya, Takahiro Higuchi, Shota Konishi, Kenichi Nakajima & Norihisa Tonami

  2. Department of Radiology, Fukui Prefecture Hospital, Fukui, Japan

    Eui-Hyo Hwang

  3. Department of Radiology, Asahikawa Medical College, Asahikawa, Japan

    Noriyuki Shuke

Authors
  1. Xiao-Feng Li
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  2. Junichi Taki
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  3. Seigo Kinuya
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  4. Takahiro Higuchi
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  5. Shota Konishi
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  6. Eui-Hyo Hwang
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  7. Noriyuki Shuke
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  8. Kenichi Nakajima
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  9. Norihisa Tonami
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Correspondence to Junichi Taki.

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Li, XF., Taki, J., Kinuya, S. et al. Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection. Ann Nucl Med 17, 489–493 (2003). https://doi.org/10.1007/BF03006440

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  • DOI: https://doi.org/10.1007/BF03006440

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