Abstract
Carbonated lidocaine is believed to penetrate membranes more rapidly than its hydrochloride salt and could possibly cause higher serum levels. To compare serum levels, arterial blood samples drawn at intervals were analyzed in a group of 18 patients under epidural anaesthesia with equivalent doses of lidocaine hydrochloride and lidocaine hydrocarbonate, with and without epinephrine.
Results show that serum levels were significantly higher when lidocaine hydrocarbonate was used for epidural analgesia.
Résumé
Dix-huit patients soumis à une chirurgie sous anesthésie épidurale ont été étudiés dans le but de vérifier l’hypothèse d’une plus grande diffusion de la lidocaïne carbonatée avec production de taux sériques plus élevés. Des dosages artériels ont été faits à périodes fixes après l’injection épidurale de 15 ml d’hydrochlorure de lidocaïne 2% ou de lidocaïne carbonatée avec ou sans épinéphrine. L’étude a confirmé l’hypothèse d’une plus grande diffusion de la lidocaïne carbonatée avec des taux sériques plus élevés.
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References
Bromage, P.R. &Robson, J.G. Concentrations of lignocaine in the blood after intravenous, intramuscular, epidural and endotracheal administration. Anaesthesia16: 461 (1961).
Albright, G.H. Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology51: 285 (1979).
Bromage, P.R. A comparison of the hydrochloride and carbon dioxide salts of lidocaine and prilocaine in epidural analgesia. Acta Anaesth. Scand. Suppl.XVl: 55 (1965).
Cobb, M.E., Buckley, N., Hu, M.W., Miller, J.G., Singh, P. &Schneider, R.S. Homogeneous enzyme immunoassay for lidocaine in serum. Clin. Chem.23: 1161(1977).
Shnider, S.M. &Way, E.L. Plasma levels of lidocaine (xylocaine) in mother and newborn following obstetrical conduction anesthesia: clinical applications. Anesthesiology29: 951 (1968).
Sasyniuk, B.I. &Ogilvie, R. Antiarrhythmic drugs: electrophysiological pharmacokinetic considerations. Annu. Rev. Pharmacol.15: 131 (1975).
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Martin, R., Lamarche, Y. & Tétreault, L. Effects of carbon dioxide and epinephrine on serum levels of lidocaine after epidural anaesthesia. Canad. Anaesth. Soc. J. 28, 224–227 (1981). https://doi.org/10.1007/BF03005504
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DOI: https://doi.org/10.1007/BF03005504