Summary
The effect of isoflurane (Forane*) anaesthesia and surgery on thyroid function was investigated in nine male patients, Isoflurane anaesthesia alone for 30 minutes prior to the start of surgery increased plasma triiodothyronine uptake (T3U) and thyroxine (T4) level by 18 and 20 per cent, respectively. Free thyroxine index (FTI) values in blood increased by 62 per cent during the same period. One hour of surgical procedure further elevated these parameters. Our data indicate that isoflurane anaesthesia and surgery increase circulating thyroxine in man.
RéSUMé
L’effet de l’anesthésie à l’isoflurane (Forane) et de la chirurgie sur la fonction thyroïdienne a fait l’objet d’une étude chez neuf patients. L’anesthésie à l’isoflurane seul pendant 30 min avant le début de la chirurgie a provoqué une augmentation de la captation de la triiodothyronine (T3U) et de la thyroxine (T4) de 18 et 20 pour cent respectivement. La valeur de l’index de thyroxine libre dans le sang a augmenté de 62 pour cent durant cette même période. La chirurgie ellemême a davantage augmenté ses paramètres. Ces données semblent indiquer que l’anesthésie à l’isoflurane et la chirurgie de la thyroïde augmentent le taux de thyroxine circulante chez l’homme.
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References
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Oyama, T., Latto, P., Holaday, D.A. et al. Effect on isoflurane anaesthesia and surgery on thyroid function in man. Canad. Anaesth. Soc. J. 22, 474–477 (1975). https://doi.org/10.1007/BF03004862
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DOI: https://doi.org/10.1007/BF03004862