Conclusion
We are convinced by this study that the risk of a loss of kidney concentrating power occurring with methoxyflurane is high, compared with a nitrous-narcotic-relaxant technique. Children appear to tolerate it better. Methoxyflurane, if used in adults, should be confined to brief procedures only (probably less than 30 minutes ). The risk of loss of concentrating power appears to increase with duration of exposure. There is a strong positive correlation between loss of concentrating power and serum inorganic fluoride levels, usually best demonstrated on the fifth post-operative day.
Résumé
Cette étude conclut que le risque de perte de pouvoir de concentration rénale après usage de methozyflurane est élevé par comparaison à une technique utilisant le protoxyde d’azote avec un narcotique et un relaxant.
Les enfants semblent moins touchés que les adultes chez lesquels on devrait restreindre son usage aux interventions de courte durée (moins de 30 minutes). Le risque de perte du pouvoir de concentration rénale semble augmenter avec la durée de l’anesthésie au methoxyflurane.
Une corrélation fortement positive existe entre la perte du pouvoir de concentration rénale et les taux sériques de fluor inorganique, corrélation démontrable en particulier au cinquième jour post-opératoire.
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An erratum to this article is available at http://dx.doi.org/10.1007/BF03004987.
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McCaughey, T.J., Dunkley, M., Batra, M.S. et al. Effect of methoxyflurane on renal concentrating power. Canad. Anaesth. Soc. J. 22, 61–69 (1975). https://doi.org/10.1007/BF03004819
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DOI: https://doi.org/10.1007/BF03004819