Summary
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1.
Difluoromethyl l,l,2-trifluoro-2-chloro ethyl ether (DFMTFCE), a proposed new anaesthetic agent, was administered to dogs by open-drop and produced smooth anaesthesia without salivation, irritation, or nausea.
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When epinephrine was given intravenously to 16 dogs asleep with DFMTFCE, three went into ventricular fibrillation.
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3.
The concentration of DFMTFCE required for surgical anaesthesia was roughly twice that with halothane for the same animals.
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4.
A latin square administration of DFMTFCE, halothane, methoxyflurane, and fluroxene demonstrated no significant effects on liver enzyme activity following the use of any of the drugs.
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5.
Blood glucose rose moderately with DFMTFCE; urea nitrogen was unchanged.
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6.
In eight volunteer subjects, DFMTFCE afforded a pleasant induction. Blood pressure dropped, as did cardiac output when anaesthesia deepened. The degree of analgesia was similar to that experienced with halothane. Spontaneous respiration ceased on attainment of surgical anaesthesia. Changing from oxygen to air produced mild hypoxaemia, at which time cardiac output increased. Waking was rapid. Three of the eight volunteers were nauseated for a short time during recovery.
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7.
Eleven surgical patients were given DFMTFCE for anaesthesia; the course was similar to that with halothane.
Résumé
L’administration, en goutte à goutte, de léther difluoro 1, 1, 2-trifluoro-2-chloro éthyle (DFMTFCE) à des chiens a produit une anesthésie douce et sans salivation. L’induction et le reveil ont été rapides et sans nausée ni vomissement.
Une heure d’anesthésie avec DFMTFCE chez des chiens a é1evé 1égèrement le taux du glucose sanguin; l’azote uréique et les taux de plusieurs ensymes sont demeures stables. L’administration d’épinéphrine, par voie endoveineuse, a entrainé une fibrillation ventriculaire chez trois chiens sur 16.
Une expérience (carré latin) ou ont ét6é employés, durant deux heures, le DFMTFCE, le méthoxyflurane, l’halothane et le fluroxene n’a montré aucun changement important des enzymes hepatiques ou de I’activité BSP d’aucun animal.
Une anesthésie profonde au DFMTFCE, chez huit volontaires, a diminué la respiration, la tension sanguine et le débit cardiaque. Le réveil a été rapide.
Le DFMTFCE a été donné comme agent anesthésique à onze opérés. L’allure de l’anesthésie a été comparable à celle que nous observons avec l’halothane.
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References
Meek, W. J.);Hathaway, H. R.); &Obth, O. S.) The Effects of Ether, Chloroform, and Cyclopropane on Cardiac Outomaticity. J. Pharmacol. & Exper. Therap.62: 240 (1937).
Nelson, N.) Photometric Adaption of Somogyi Method for Determination of Glucose. J. Biol. Chem.153: 375 (1944).
Kabr, W. G.) Method for Determination of Blood Urea Nitrogen, J. Lab. & Clin. Med. 9: 329(1924).
SDbley, J. A.) &Lehninger, A. H.) Determination of Aldolase in Animal Tissues. J. Biol. Chem. 153:375 (1944).
Bell, J. K.) &Baron, D. N.) Colorimetric Estimation of Serum Isocitric Dehydrogenase. J. Clin. Path.12: 582 (1959).
Reitman, S.) &Frankel, S.) A Colorimetric Method for the Determination of Serum Glutamic Oxaloacetic and Glutamic Pyruvic Transaminases. Am. J. Clin. Path.28: 56 (1957).
De Ritis, F.);Coltorti, M.); &Giusti, G.) Attivita Transaminasica del Serio Umano Nell’spatite Virale. Minerva med.46: 1207 (1955).
Wroblewski, F.) &Gregory, K.) Lactic Acid Dehydrogenase Isoenzymes and Their Distribution in Normal Tissues and Plasma in Disease States. Ann. New York Acad. Sc. 94: 912 (1961).
Green, M. N.); TSOU, K-C; Bressler, R.; & Seligman, A. M. The Colorimetric Determination of Leucine Amino Peptidase Activity with L-Leucyl-β-Nephthylamide Hydrochloride. Arch. Biochem. Biophys.57: 458 (1955).
Seldinger, S. I.) Catheter Replacement of the Needle in Percutaneous Arteriography: A New Technique. Acta radiol. 39: 368 (1953).
Virtue, R. W.);Vogel, J. H. K.).;Press, P.); &Grover, R. F.) Respiratory and Hemodynamic Measurements during Anesthesia: Use of Trifluoroethyl Vinyl Ether and Halothane J.A.M.A.179: 224 (1962).
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Supported by a grant from the Air Reduction Company.
Drs. Virtue, Lund, and Phelps are respectively Professor, Instructor, and Resident in Anesthesiology. Drs. Vogel and Beckwitt are respectively Advanced Research Fellow, American Heart Association, and Instructor in Medicine, supported bythe Idaho Heart Association. Mr. Heron is a Research Associate.
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Virtue, R.W., Lund, L.O., Phelps, M. et al. Difluoromethyl l,l,2-trifluoro-2-chloroethyl ether as an anaesthetic agent: Results with dogs, and a preliminary note on observations with man. Can. Anaes. Soc. J. 13, 233–241 (1966). https://doi.org/10.1007/BF03003545
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DOI: https://doi.org/10.1007/BF03003545