Abstract
This study analyzed the relationship between psychosocial factors and progression in intima media thickness (IMT). In 1998 and 2002, 95 healthy participants underwent a clinical examination, including ultrasound of the arteria carotis communis (ACC). IMT progression in women was 0.033 mm/year (SD = 0.033) and in men 0.048 mm/ year (SD = 0.033). For cohabiting women as opposed to single women, the means for total IMT progression over the 4 years were, respectively, 0.137 (SE = 0.019) and 0.016 (SE = 0.048) mm. For women with above average as opposed to below average mean scores of effort, IMT progression were 0.149 (SE = 0.026) and 0.098 (SE = 0.024) mm, respectively. For men without children as opposed to men with children, mean scores for IMT progression were 0.231 (SE = 0.029) and 0.137 (SE = 0.028) mm, respectively. For men above average as opposed to those below average, scores of effort—reward imbalance IMT progression were 0.216 (SE = 0.030) and 0.155 (SE = 0.027) mm, respectively. Adjustment for confounders did not change the results significantly. We found that psychosocial factors were independent significant predictors of IMT progression. The associations were different between the genders.
Similar content being viewed by others
References
Agewall, S., Wikstrand, J., Dahlöf, C., & Fagerberg, B. (1996). Negative feelings (discontent) predict progress of intima-media thickness of the common carotid artery in treated hypertensive men at high cardiovascular risk. 1996.American Journal of Hypertension, 9, 545–550.
Aminbakhsh, A., & Mancini, G. B. (1999). Carotid intima-media thickness measurements: What defines an abnormality? A systematic review.Clinical and Investigative Medicine, 22, 149–157.
Barnett, P. A., Spence, J. D., Manuck, S. B., & Jennings, J. R. (1997) Psychological stress and the progression of carotid artery disease.Journal of Hypertension, 15, 49–55.
Bosma, H., Peter, R., Siegrist, J., & Marmot, M. (1998). Two alternative job stress models and the risk of coronary heart disease.American Journal of Public Health, 88, 68–74.
Burke, G. L., Evans, G. W., Riley, W. A., Sharrett, A. R., Howard, G., Barnes, R. W., et al. (1995). Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults: The atherosclerosis risk in communities (ARIC) study.Stroke, 26, 386–391.
Chambless, L. E., Folsom, A. R., Davis, V., Sharrett, R., Heiss, G., Sorlie, P., et al. (2002). Risk factors for progression of common carotid atherosclerosis: The atherosclerosis risk in communities study, 1987-1998.American Journal of Epidemiology, 155, 38–47.
Craven, T. E., Ryu, J. E., Espeland, M. A., Kahl, F. R., McKinney, W. M., Toole, J. F., et al. (1990). Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis: A case-control study.Circulation, 82, 1230–1242.
Crouse, J. R., III. (2001). Predictive value of carotid 2-dimensional ultrasound.American Journal of Cardiology, 88, 27E-30E.
Crouse, J. R., Craven, T. E., Hagaman, A. P., & Bond, G. (1995). Association of coronary disease with segment-specific intimalmedial thickening of the extracranial carotid artery.Circulation, 92, 1141–1147.
Crouse, J. R., III, Tang, R., Espeland, M. A., Terry, J. G., Morgan, T., & Mercuri, M. (2002). Associations of extracranial carotid atherosclerosis progression with coronary status and risk factors in patients with and without coronary artery disease.Circulation 106, 2061–2066.
Eller, N. H., Malmberg, B., & Bruhn, P. (2005). Heart rate variability and intima media thickness.International Journal of Behavioral Medicine, 13, 201–213.
Eller, N. H., & Netterstrøm, B. (2001). The intima media thickness and conventional coronary risk factors.International Angiology, 20, 118–125.
Eller, N. H., Netterstrøm, B., & Allerup, P. (2005). Progression in intima media thickness: The significance of hormonal biomarkers of chronic stress.Psychoneuroendocrinology, 30, 715–723.
Eller, N. H., Netterstrøm, B., & Hansen A. M. (2001). Cortisol in urine and saliva: Relations to the intima-media thickness, IMT.Atherosclerosis, 159, 175–185.
Everson, S. A, Kaplan, G. A., Goldberg D. E., Salonen, R., & Salonen, J. T. (1997). Hopelessness and 4-year progression of carotid atherosclerosis.Arteriosclerosis, Thrombosis, and Vascular Biology, 17, 1490–1495.
Everson, S. A., Lynch, J. W., Chesney, M. A., Kaplan, G. A., Goldberg, D. E., Shade, S. B., et al. (1997). Interaction of workplace demands and cardiovascular reactivity in progression of carotid atherosclerosis: Population based study.British Medical Journal, 314, 553–558.
Fujii, K., Abe, I., Ohya, Y., Ohta, Y., Arima, H., Akasaki, T., et al. (2003). Risk factors for the progression of early carotid atherosclerosis in a male working population.Hypertension Research, 26, 465–471.
Geroulakos, G., O’Gorman, D. J., Kalodiki, E., Sheridan, D. J., & Nicolaides, A. N. (1994). The carotid intima-media thickness as a marker of the presence of severe symptomatic coronary artery disease.European Heart Journal, 15, 781–785.
Gnasso, A., Carrallo, C., Irace, C., Spagnuolo, V., De Novara, G., Mattioli, P. L., et al. (1996). Association between intima-media thickness and wall shear stress in common carotid arteries in healthy male subjects.Circulation, 94, 3257–3262.
Heiss, G., Sharrett, A. R., Barnes, R., Chambless, L. E., Szklo, M., & Alzola, C. (1991). Carotid atherosclerosis measured by B-mode ultrasound in populations: Associations with cardiovascular risk factors in the ARIC study.American Journal of Epidemiology, 134, 250–256.
Hodis, H. N., Mack, W. J., LaBree, L., Selzer, R. H., Liu, C. R., Liu, C. H., et al. (1998). The role of carotid arterial intima-media thickness in predicting clinical coronary events.Annals of Internal Medicine, 128, 262–269.
Johnson, J. V., & Hall, E. M. (1988). Job strain, work place social support, and cardiovascular disease: A cross-sectional study of a random sample of the Swedish population.American Journal of Public Health, 78, 1336–1342.
Julkunen, J., Salonen, R., Kaplan, G. A., Chesney, M. A., & Salonen, J. T. (1994). Hostility and the progression of carotid atherosclerosis.Psychosomatic Medicine, 56, 519–525.
Karasek, R. A., Russell, R. S., & Theorell T. (1982). Physiology of stress and regeneration in job related cardiovascular illness.Journal of Human Stress, 8, 29–42.
Karasek, R. A., Theorell, T., Schwartz, J. E., Schnall, P. L., Pieper, C. F., & Michela, J. L. (1988). Job characteristics in relation to the prevalence of myocardial infarction in the US health examination survey (HES) and the health and nutrition examination survey(HANES).AmericanJournalofPublicHealth, 78,910–918.
Kivimaki, M., Leino-Arjas, P., Luukkonen, R., Riihimaki, H., Vahtera, J., & Kirjonen, J. (2002). Work stress and risk of cardiovascular mortality: Prospective cohort study of industrial employees.British Medical Journal, 325, 857–860.
Lakka, T. A., Lakka, H-M., Salonen, R., Kaplan, G. A., & Salonen, J. (2001). Abdominal obesity is associated with accelerated progression of carotid atherosclerosis inmen.Atherosclerosis, 154, 497–504.
Lynch, J., Kaplan, G. A., Salonen, R., Cohen, R. D., & Salonen, J. T. (1995). Socioeconomic status and carotid atherosclerosis.Circulation, 92, 1786–1792.
Lynch, J., Kaplan, G. A., Salonen, R., & Salonen, J. T. (1997). Socioeconomic status and progression of carotid atherosclerosis.Arteriosclerosis, Thrombosis, and Vascular Biology, 17, 513–519.
Lynch, J., Krause, N., Kaplan, G. A., Salonen, R., & Salonen, J. T. (1997). Workplace demands, economic reward, and progression of carotid atherosclerosis.Circulation, 96, 302–307.
Netterstrøm, B., Kristensen, T. S., Damsgaard, M. T., Olsen, O., & Sjol, A. (1991). Job strain and cardiovascular risk factors: A cross sectional study of employed Danish men and women.British Journal of Industrial Medicine, 48, 684–689.
Netterstrøm, B., Nielsen, F. E., Kristensen, T. S., Back, E., & Møller, L. (1999). Relation between job strain and myocardial infarction: A case-control study.Occupational and Environmental Medicine, 56, 339–342.
Nordstrom, C. K., Dwyer, K. M., Merz, N. B., Shircore, A., & Dwyer, J. H. (2003). Leisure time physical activity and early atherosclerosis: The Los Angeles atherosclerosis study.American Journal of Medicine, 115, 19–25.
Paterniti, S., Zureik, M., Ducimetiere, P., Touboul, P. J., Feve, J. M., & Alperovitch, A. (2001). Sustained anxiety and 4-year progression of carotid atherosclerosis.Arteriosclerosis, Thrombosis, and Vascular Biology, 21, 136–141.
Peter, R., & Siegrist, J. (2000). Psychosocial work environment and the risk of coronary heart disease.International Archives of Oc cupational and Environmental Health, 73(Suppl.), S41-S45.
Peter, R., Siegrist, J., Hallqvist, J., Reuterwall, C., & Theorell, T. (2002). Psychosocial work environment and myocardial infarction: Improving risk estimation by combining two complementary job stress models in the SHEEP study.Journal of Epidemilogy and Community Health, 56, 294–300.
Pikhart, H., Bobak, M., Siegrist, J., Pajak, A., Rywik, S., Kyshegyi, J., et al. (2001). Psychosocial work characteristics and self-rated health in four post-communist countries.Journal of Epidemiology and Community Health, 55, 624–630.
Prati, P., Vanuzzo, D., Casaroli, M., Di Chiara, A., De Biasi, F., Feruglio, G. A., et al. (1992). Prevalence and determinants of carotid atherosclerosis in a general population.Stroke, 23, 1705–1711.
Rhodes, M. E., & Rubin, R. T. (1999). Functional sex differences (“sexual diergism”) of central nervous system cholinergic systems, vasopressin, and hypothalamic—pituitary—adrenal axis activity in mammals: A selective review.Brain Research Reviews, 30, 135–152.
Rosvall, M., Östergren, P. O., Hedblad, B., Isacsson, S—O., Janzon, L., & Berglund, G. (2002). Work—related psychosocial factors and carotid atherosclerosis.Internationl Journal of Epidemiology, 31, 1169–78.
Rozanski, A., Blumenthal, J. A., Davidson, K. W., Saab, P. G., & Kubzansky, L. (2005).The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: The emerging field of behavioral cardiology.Journal of the American College of Cardiology, 45, 637–651.
Salonen, R., & Salonen, J. T. (1991). Determinants of carotid intima-media thickness: A population-based ultrasonography study in eastern Finnish men.Journal of Internal Medicine, 229, 225–231.
Salonen, J. T., & Salonen, R.(1993). Ultrasound B—mode imaging in observational studies of atherosclerotic progression.Circulation, 87, II-56-II-65.
Salonen, J. T., Seppanen, K., Rauramaa, R., & Salonen, R. (1989). Risk factors for carotid atherosclerosis: The Kuopio ischaemic heartdiseaseriskfactorstudy.Annals of Medicine, 21,227–229.
Sandanger, I., Nygard, J. F., Sorensen, T., & Moum, T. (2004). Is women’s mental health more susceptible than men’s to the influence of surrounding stress?Social Psychiatry and Psychiatric Epidemiology, 39, 177–184.
Sander, D., Kukla, C., Klingenhöfer, J., Winbeck, K., & Conrad, B. (2000). Relationship between circadian blood pressure patterns and progression of early carotid atherosclerosis.Circulation, 102, 1536–1541.
Siegrist, J. (1996). (1996). Adverse health effects of high-effort/ low-reward conditions.Journal of Occupational Health Psychology, 1, 27–41.
Siegrist, J., & Peter, R. (1996). Threat to occupational status control and cardiovascular risk. 1996.Israel Journal of Medical Science, 32, 179–184.
Siegrist, J., Peter, R., Junge, A., Cremer, P., & Seidel, D. (1990). Low status control, high effort at work and ischemic heart disease: Prospective evidence from blue-collar men.Social Science and Medicine, 31, 1127–1134.
Siegrist, J., Starke, D., Chandola, T., Godin, I., Marmot, M., Niedhammer, I., and Peter, R. (2004). The measurement of effort-reward imbalance at work: European Comparisons.Social Science and Medicine, 58, 1483–1499.
Simon, A., Gariepy, J., Chironi, G., Megnien, J. L., & Levenson, J. (2002). Intima-media thickness: A new tool for diagnosis and treatment of cardiovascular risk.Journal of Hypertension, 20, 159–169.
Terry, J. G., Tang, R., Davis, D. H., Espeland, M. A., Morgan, T. M., & Crouse, J. R. (2000). Progression of carotid artery atherosclerosis: Associations with CAD and risk factors.Circulation, 102, II-835-II-836.
Ursin, H., & Eriksen, H. R. (2004). The cognitive activation theory of stress.Psychoneuroendocrinology, 29, 567–592.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Eller, N.H., Netterstrøm, B. Psychosocial factors at home and at work and four-year progression in intima media thickness. Int. J. Behav. Med. 14, 21–29 (2007). https://doi.org/10.1007/BF02999224
Issue Date:
DOI: https://doi.org/10.1007/BF02999224