Skip to main content
SpringerLink
Log in

the infection of ebv for cervical epithelium-a new causitive agent in the development of cervical carcinomas?

  • Basic Investigation
  • Published:
Chinese Journal of Cancer Research

Abstract

Epstein-Barr virus was considered as a caustive agent for Burrkitt’s lymphoma and non- malignant B lymphocytes proliferation. The recent studies revealed the striking association of the infection of EBV with the development of human epithelial tumors. 43 specimens of normal exfoliated cervical epithelial cells, 47 biopsies of chronic cervicitis and 80 tissue samples of cervical carcinomas were tested for the presences of EBV W fragments by using dot blot hybridization method. The results showed that the detectable rates of EBV DNA sequences in the normal exfoliated epithelium, the chronic cervicitis and cervical carcinomas were 44.16%, 12.77% and 13.75%, respectively. Eleven EBV positive DNA samples from cervical cancers were also examined for the presence of HPV DNA. The result showed 9 out of 11 were HPV DNA positive, the cultanious infectious rate of both viruses was about 81.81%.

In this paper, the EBV genomes existed in the part of biopsies of cervical carcinomas were first reported. The results implied that the development of cervical cancer might be associated with asymptomatic EBV infection in early stage and might be the result from the synergistic carcinogenesis of EBV with other cervical oncoviruses, especially with HPV.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gissman L, et al. Papillomaviruses and their association with cancer in animals and in man. Cancer Surv 1984; 3:161.

    Google Scholar 

  2. Dust M, et al. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Nat Acad Sci (Wash) 1983; 80: 3812.

    Article  Google Scholar 

  3. Zhang Wei, et al. Detection of HPV 16 DNA in cervical carcinoma by paraffin section hybridization. Proc CAMS and PUMC 1990; 5:174.

    CAS  Google Scholar 

  4. Pirisi L, et al.Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J Virol 1987; 61:1061.

    PubMed  CAS  Google Scholar 

  5. Yasumoto S, et al. HPV type 16 DNA-induced malignant transformation of NIH 3T3 cells. J Virol 1986; 57:572.

    PubMed  CAS  Google Scholar 

  6. Lehn H, et al. Papillomavirus genomes in human cervical tumors: analysis of their transcriptional activity. Proc Nat Acad Sci (Wash) 1985; 69:187.

    Google Scholar 

  7. Zur Hausen H, et al. Intracellular survillance of persisting viral infection. Lancet 1986; I: 489.

    Google Scholar 

  8. Epstein MA, et al. The Epstein-Barr virus: Recent Advances. London Heinemann. 1986.

  9. Yao QY, et al. A re-examination of the EBV carrier state in healthy seropositive individuals. Inter J Can 1985; 35:35.

    Article  CAS  Google Scholar 

  10. Brichacek B, et al. Presence of EBV DNA in carcinoma of the palatine tonsil. JNCI 1984; 72:809.

    PubMed  CAS  Google Scholar 

  11. Raab-Traub N, et al. EBV DNA structure and oncogene expression in EBV- associated malignancies. Second International symposium on EBV and associated malignant disease. London: Humana Press. 1987; 423–428.

    Google Scholar 

  12. Brichacek B, et al. Association of some supra-glottic laryngeal carcinomas with EBV. Inter J Cancer 1983; 32:193.

    Article  CAS  Google Scholar 

  13. Saemundsen AK, et al. EBV, nasopharyngeal and salivary gland carcinomas in Greeland Eskimoes. Bri J can 1982; 46:721.

    CAS  Google Scholar 

  14. Leyvraz S, et al. Association of EBV with thymic carcinoma. New Eng J Med 1985; 312:1296.

    PubMed  CAS  Google Scholar 

  15. Sixbey JW, et al. Replication of EBV in human epithelial cells infectedin vitro. Nature 1983; 306:480.

    Article  PubMed  CAS  Google Scholar 

  16. Sixbey JW, et al. Human epithelial cell expression of an EBV receptor. J General virol 1987; 68:805.

    Article  Google Scholar 

  17. Greenspan D, et al. Oral hairy leukoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus. Lancet 1984; ii:831.

    Article  Google Scholar 

  18. Greenspan JS, et al. Replication of EBV within the epithelial cells of oral hairy leucoplasia, an AIDS-associated lesion. New Eng J Med 1985; 313:1564.

    Article  PubMed  CAS  Google Scholar 

  19. Friedman-Kien AE, et al. Viral origin of hairy leukoplakia. Lancet 1986; ii:694.

    Article  Google Scholar 

  20. Sixbey JW, et al. A second site for EBV shedding: the uterin cervix. Lancet 1986; ii:1122.

    Article  Google Scholar 

  21. Bevan IS, et al. Oncogenic viruses and cervical cancer. Lancet April 1989; 22.

  22. Zeng Y, et al. EBV activation by human semen principle; synergistic effect of culture fluids of bacteria isolated from patients with carcinoma of uterin cervix. Cancer Letters 1985; 28:311.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Department of Cancer Virology, Cancer Institute, CAMS, China

    Zhang Wei, Jin Shunqian, Li Junyao, Liang Xiao, Ming Lihua, Wang Xiaohong, Shang Ming, Wu Airu, Sun Jianheng, Wang Xixia, Zhang Wenhua & Liu Zhiming

  2. The Department of Gynecological Oncology, Cancer Hospital, CAMS, China

    Wu Airu

Authors
  1. Zhang Wei
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jin Shunqian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Li Junyao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Liang Xiao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ming Lihua
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wang Xiaohong
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Shang Ming
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Wu Airu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Sun Jianheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Wang Xixia
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Zhang Wenhua
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Liu Zhiming
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhang, W., Jin, S., Li, J. et al. the infection of ebv for cervical epithelium-a new causitive agent in the development of cervical carcinomas?. Chin J Cancer Res 4, 23–29 (1992). https://doi.org/10.1007/BF02996398

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02996398

Key works

Search

Navigation