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Gastric mucosa: long-term outcome after cure ofHelicobacter pylori infection

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Abstract

The histopathological changes due to chronicHelicobacter pylori infection are well characterized. Nevertheless, the clinical and pathological outcomes resulting from the cure of this infection remain incompletely described. In particular, the influence of eradication ofH. pylori on nonulcer dyspepsia, the long-term effects ofH. pylori eradication on gastric atrophy and intestinal metaplasia, and the role ofH. pylori eradication in the prevention of gastric cancer are still unclear. We reviewed 38 studies reported between 1993 and 1999 on the outcome of various disorders related toH. pylori infection after successful eradication. There is general agreement concerning the regression of chronic gastritis, lymphoid follicles, and limited-stage lowigrade MALT lymphomas of the gastric mucosa after eradication ofH. pylori infection. Conversely, there are still major questions on whetherH. pylori eradication improves the outcome of premalignant lesions, such as atrophy, intestinal metaplasia, and dysplasia. Finally, some extragastric idiopathic diseases seem to improve in consequence of the eradication of the infection, although there are still no definitive data to support this.

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Authors and Affiliations

  1. Department of Pathology, Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Boulevard, 77030, Houston, TX, USA

    Francesco Franceschi, Robert M. Genta & Antonio R. Sepulveda

  2. Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA

    Robert M. Genta & Antonio R. Sepulveda

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  1. Francesco Franceschi
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Franceschi, F., Genta, R.M. & Sepulveda, A.R. Gastric mucosa: long-term outcome after cure ofHelicobacter pylori infection. J Gastroenterol 37 (Suppl 13), 17–23 (2002). https://doi.org/10.1007/BF02990094

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